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Education ?

Medical School Score Rankings
Michigan State University (1980)
Top 50%

Awards & Distinctions ?

Merck Excellence Awards (4), 1998-1999
Merck Special Achievement Award, 1999
American Society for Dermatologic Surgery
National Psoriasis Foundation

Affiliations ?

Dr. Mathes is affiliated with 1 hospitals.

Hospital Affiliations



  • Grand View Hospital
    700 Lawn Ave, Sellersville, PA 18960
    Top 50%
  • Publications & Research

    Dr. Mathes has contributed to 13 publications.
    Title Randomized, Double-blind Clinical Evaluation of the Efficacy and Safety of Topical Eflornithine Hcl 13.9% Cream in the Treatment of Women with Facial Hair.
    Date April 2007
    Journal International Journal of Dermatology
    Title Two Prodrugs of Potent and Selective Glur5 Kainate Receptor Antagonists Actives in Three Animal Models of Pain.
    Date August 2005
    Journal Journal of Medicinal Chemistry

    Amino acids 5 and 7, two potent and selective competitive GluR5 KA receptor antagonists, exhibited high GluR5 receptor affinity over other glutamate receptors. Their ester prodrugs 6 and 8 were orally active in three models of pain: reversal of formalin-induced paw licking, carrageenan-induced thermal hyperalgesia, and capsaicin-induced mechanical hyperalgesia.

    Title Substituted Furo[3,2-b]pyridines: Novel Bioisosteres of 5-ht 1f Receptor Agonists.
    Date August 2004
    Journal Bioorganic & Medicinal Chemistry Letters

    Synthesis and evaluation of a series of 2,3,5- and 3,5-substituted furo[3,2-b]pyridines were undertaken in order to investigate their utility as bioisosteres of 5-HT(1F) receptor agonist indole analogues, 1-3. The replacement proved to be effective, providing compounds with similar 5-HT(1F) receptor affinity and improved selectivity when compared with the indole analogues. Through these studies we identified 4-fluoro-N-[3-(1-methyl-piperidin-4-yl)-furo[3,2-b]pyridin-5-yl]-benzamide (5), a potent and selective 5-HT(1F) receptor agonist with the potential to treat acute migraine.

    Title Novel Potent 5-ht(1f) Receptor Agonists: Structure-activity Studies of a Series of Substituted N-[3-(1-methyl-4-piperidinyl)-1h-pyrrolo[3,2-b]pyridin-5-yl]amides.
    Date August 2003
    Journal Journal of Medicinal Chemistry

    Compound 1a (LY334370), a selective 5-HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of migraine and demonstrated clinical efficacy for the acute treatment of migraine. Although 1a was greater than 100-fold selective over both the 5-HT(1B) and 5-HT(1D) receptors, it exhibited appreciable 5-HT(1A) receptor affinity. Described here is the synthesis and evaluation of a series of pyrrolo[2,3-c]pyridine and pyrrolo[3,2-b]pyridine (2a and 3a) as well as pyrrolo[3,2-d]pyrimidine (4a) analogues of 1a, compounds prepared in an effort to identify SSOFRAs with improved selectivity over other 5-HT(1) receptor subtypes. The pyrrolo[3,2-b]pyridine analogue 3a showed high 5-HT(1F) receptor affinity but offered no improvement in selectivity compared to 1a. However, the C-5 acetamide derivative, 3b, was greater than 100-fold selective over the 5-HT(1A), 5-HT(1B), and 5-HT(1D) receptors. SAR studies of this series determined that alkylamides in particular exhibited high selectivity for the 5-HT(1F) receptor. Replacement at C-5 with other substituents decreased affinity or selectivity. These SAR studies identified SSOFRAs that demonstrated oral activity in the neurogenic plasma protein extravasation model, a model indicative of antimigraine activity.

    Title Ethyl (3s,4ar,6s,8ar)-6-(4-ethoxycar- Bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic Ester: a Prodrug of a Glur5 Kainate Receptor Antagonist Active in Two Animal Models of Acute Migraine.
    Date October 2002
    Journal Journal of Medicinal Chemistry

    Amino diacid 3, a highly selective competitive GluR5 kainate receptor antagonist, exhibited high GluR5 receptor affinity and selectivity over other glutamate receptors. Its diethyl ester prodrug 4 was orally active in two models of migraine: the neurogenic dural plasma protein extravasation model and the nucleus caudalis c-fos expression model. These data suggest that a GluR5 kainate receptor antagonist might be an efficacious antimigraine therapy with a novel mechanism of action.

    Title Multiple Fire Ant Stings: Report of 3 Cases and Review of the Literature.
    Date February 2001
    Journal Cutis; Cutaneous Medicine for the Practitioner

    Imported fire ant sting reactions are becoming an increasing problem in the United States. It is important for clinicians to be familiar with their possible cutaneous and noncutaneous presentations. We present 3 cases with multiple fire ant stings, followed by a review of the literature.

    Title Periorbital Edema As the Presenting Sign of Juvenile Dermatomyositis.
    Date April 1999
    Journal Pediatric Dermatology

    We report a case of juvenile dermatomyositis that presented with periorbital edema. Dermatomyositis is an autoimmune disorder with cutaneous manifestations including heliotrope patches, Gottron's papules, periungual telangiectasisas, and subcutaneous calcifications. Periorbital edema may accompany the classic heliotrope rash and, as in this case, may be the only presenting sign of juvenile dermatomyositis.

    Title Skin Biopsy Techniques for the Internist.
    Date March 1998
    Journal Journal of General Internal Medicine : Official Journal of the Society for Research and Education in Primary Care Internal Medicine

    OBJECTIVE: To review three commonly performed skin biopsy procedures: shave, punch, and excision. DATA SOURCES: English-language articles identified through a MEDLINE search (1966-1997) using the MeSH headings skin and biopsy, major dermatology and primary care textbooks, and cross-references. STUDY SELECTION: Articles that reviewed the indications, contraindications, choice of procedure, surgical technique, specimen handling, and wound care. DATA EXTRACTION: Information was manually extracted from all selected articles and texts; emphasis was placed on information relevant to internal medicine physicians who want to learn skin biopsy techniques. DATA SYNTHESIS: Shave biopsies require the least experience and time but are limited to superficial, nonpigmented lesions. Punch biopsies are simple to perform, have few complications, and if small, can heal without suturing. Closing the wound with unbraided nylon on a C-17 needle will enhance the cosmetic result but requires more expertise and time. Elliptical excisions are ideal for removing large or deep lesions, provide abundant material for many studies, and can be curative for a number of conditions, but require the greatest amount of time, expertise, and office resources. Elliptical excisions can be closed with unbraided nylon using a CE-3 or FS-3 needle in thick skin or a P-3 needle on the face. All specimens should be submitted in a labeled container with a brief clinical description and working diagnosis. CONCLUSIONS: Skin biopsies are an essential technique in the management of skin diseases and can enhance the dermatologic care rendered by internists.

    Title Chronic Venous Insufficiency and Venous Ulceration.
    Date September 1997
    Journal Journal of General Internal Medicine

    OBJECTIVE: To review and summarize the literature on the normal venous circulation of the leg, and the epidemiology, pathophysiology, and treatment of chronic venous insufficiency (CVI). DATA SOURCES: English-language articles identified through a MEDLINE search (1966-1996) using the terms venous insufficiency or varicose ulcer and epidemiology, pathophysiology, diagnosis, and clinical trial (pt), and selected cross-references. STUDY SELECTION: Articles on epidemiology, pathophysiology, and treatment of CVI. Randomized, controlled studies were specifically sought for treatment efficacy. DATA EXTRACTION: Data were manually extracted from selected studies and reviews: emphasis was placed on information relevant to the general internist. DATA SYNTHESIS: Chronic venous insufficiency is a common primary care problem associated with significant morbidity and health care costs. The clinical spectrum of disease ranges from minor cosmetic concerns to severe fibrosing panniculitis and ulceration. Duplex Doppler ultrasonography may be the single best test to rule out deep venous thrombosis and other entities that can mimic CVI. Leg elevation and compression stockings are effective treatments for CVI; recalcitrant cases may require intermittent pneumatic compression. Topical antiseptics, antibiotics, enzymes, or growth factors offer no clear advantages in ulcer healing. Ulcer dressings remain a matter of convenience, cost, and physician judgment. The role of surgery in CVI appears to be limited. CONCLUSIONS: Chronic venous insufficiency is a recalcitrant, recurrent medical problem. This condition can be managed by primary care physicians with relatively inexpensive treatment modalities in association with lifestyle modification.

    Title Longitudinal Nail Biopsy in Evaluation of Acquired Nail Dystrophies.
    Date June 1986
    Journal Journal of the American Academy of Dermatology

    We reviewed longitudinal nail biopsies performed at Henry Ford Hospital on patients with acquired nail dystrophies to see whether the procedure did, indeed, provide useful diagnostic information and to see which microscopic features were most helpful in histopathologic diagnosis. Clinical diagnoses included psoriasis, lichen planus, Darier's disease, isolated longitudinal defects, and diffuse thickening. We found that clinical diagnosis could be supported by histopathologic findings in eight of twenty cases of acquired nail dystrophy. Specifically, we were able to make a diagnosis of psoriasis in four cases, lichen planus in three cases, and Darier's disease in one case. The other twelve cases showed nonspecific eczematous changes. We conclude that the longitudinal nail biopsy may be a useful diagnostic tool in certain cases of acquired nail dystrophy.

    Title Seborrheic Dermatitis in Patients with Acquired Immunodeficiency Syndrome.
    Date January 1986
    Journal Journal of the American Academy of Dermatology

    Many cutaneous disorders are associated with acquired immunodeficiency syndrome. We prospectively evaluated eighteen patients with acquired immunodeficiency syndrome and twelve patients with the immunodeficiency syndrome-related complex for dermatologic disorders. A high prevalence of seborrheic dermatitis was found in patients with acquired immunodeficiency syndrome--83%, in comparison with 1% to 3% of historic control subjects. Patients with the related complex also had an increased incidence of 42%. Seborrheic dermatitis in this population was often more explosive, inflammatory, and severe than is usually seen in otherwise healthy patients. Severity of seborrheic dermatitis correlated with a poor overall prognosis in our patients. Additionally, seborrheic dermatitis may be one of the most common cutaneous manifestations of acquired immunodeficiency syndrome.

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