Otolaryngologists


Central
2799 W Grand Blvd
Detroit, MI 48202
313-916-2600
Locations and availability (1)

Awards & Distinctions ?

Associations
American Academy of Otolaryngology: Head and Neck Surgery

Publications & Research

Dr. Musgrave has contributed to 1 publication.
Title Nasal Amphotericin Irrigation in Chronic Rhinosinusitis.
Date February 2008
Journal Current Opinion in Otolaryngology & Head and Neck Surgery
Excerpt

PURPOSE OF REVIEW: To review the literature on the use of amphotericin irrigation for the treatment of chronic rhinosinusitis. RECENT FINDINGS: Although the etiology of acute rhinosinusitis is usually bacterial in nature, the exact etiology of chronic rhinosinusitis is unclear. Recent literature reports pointed to fungal colonization as a likely pathogenesis. It was hypothesized that a nonallergic eosinophilic immunoglobulin response to these fungi by the host was the cause of the symptoms, not a fungal invasion into the mucosa. The paper reviews the most recent articles investigating the use of amphotericin irrigation, as well as sprays and oral medications, of the nasal and sinus mucosa in patients with chronic rhinosinusitis. SUMMARY: The use of amphotericin for patients with chronic rhinosinusitis is not substantiated by the majority of publications. Although some studies found improvement on radiographic images, the symptoms of the disorder were not improved even with fungal eradication. Further studies need to be carried out to determine if changes in dosage, treatment time or route of administration could improve results.


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