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Internist, Infectious Disease Specialist (virus, bacteria, parasites)
49 years of experience


Education ?

Medical School Score Rankings
Northwestern University (1963)
Top 50%

Awards & Distinctions ?

American Board of Internal Medicine

Publications & Research

Dr. Janis has contributed to 12 publications.
Title Developing and Implementing a Program of Grand Rounds for Internists That is Free of Commercial Bias.
Date July 2003
Journal Annals of Internal Medicine
Title Palinopsia with Bacterial Brain Abscess and Noonan Syndrome.
Date May 1999
Journal Alaska Medicine

Though positive visual symptoms can be psychological in nature, or can result from a perceptive or anxious patients recognizing optical principals in the eye itself, this case illustrates how a thorough history is required to delineate those rarer signs which accompany serious macular or neuro-ophthalmic pathology.

Title Post-exposure Prophylaxis of Murine Rabies with Polyinosinic-polycytidylic Acid and Chlorite-oxidized Amylose.
Date November 1993
Journal Antimicrobial Agents and Chemotherapy

Chlorite-oxidized amylose (COAM), polyinosinic-polycytidylic acid [poly(I:C)], and combinations of the two drugs were evaluated for their interferon-inducing properties and their ability to protect mice against rabies infection. Post-exposure administration of one or two doses (100 mug each) of poly(I:C) significantly protected mice against rabies infection. Pretreatment of mice with COAM 3 h before poly(I:C) stimulation resulted in an enhancement of the interferon response. However, the increased interferon titers were not reflected by increased protection against rabies infection over that achieved with poly(I:C) therapy alone. Therapy with COAM alone did not protect mice against rabies but, rather, was associated with enhanced mortality.

Title Recurrent Staphylococcal Abscesses Associated with Defective Neutrophil Chemotaxis and Allergic Rhinitis.
Date August 1976
Journal Annals of Internal Medicine

Four patients with recurrent staphylococcal furonculosis and deep abscess formation were evaluated to determine if a defect in the host defense mechanism could account for the unusual incidence of infection. Each also suffered repeated allergic rhinitis, often preceding the onset of infection. A marked defect in neutrophil granulocyte chemotaxis occurred when the patients were symptomatic with rhinitis and abscess formation. Their mean chemotactic index (+/- SD) was 16 +/- 6, while that of 25 control subjects was 70 +/- 11. Neutrophil random migration, phagocytosis, bactericidal activity, and lymphocyte T-cell populations were normal, as were serum concentrations of IgA, IgG, IgM, and IgE. Serial neutrophil function tests revealed normal chemotactic responsiveness when the patients were symptom-free of allergic rhinitis and no longer having abscesses. Abnormal function returned, however, when symptoms recurred. These studies suggest that defective neutrophil function associated with allergic phenomena need not be accompanied by hyperimmunoglobulinemia E. Such defects may be intermittent, appearing when allergic symptomatology and infections develop.

Title Effects of Cytosine Arabinoside, Adenine Arabinoside, and 6-azauridine on Rabies Virus in Vitro and in Vivo.
Date March 1976
Journal The Journal of Infectious Diseases

The antiviral agents cytosine arabinoside, adenine arabinoside, and 6-azauridine were shown to inhibit the replication of rabies virus in vitro but not the replication of Sindbis virus. These same drugs were not effective in reducing the mortality rate in mice challenged with street rabies virus.

Title Therapy of Murine Rabies After Exposure: Efficacy of Polyriboinosinic-polyribocytidylic Acid Alone and in Combination with Three Rabies Vaccines.
Date December 1975
Journal The Journal of Infectious Diseases

A murine model simulating human street rabies virus infection was used to evaluate the efficacy of polyriboinosinic-polyribocytidylic acid (poly I-poly C), three rabies vaccines, and combinations of these modes of therapy administered after exposure. One or two doses of 100 mug of poly I-poly C, injected into the same intramuscular site as the challenge virus, significantly reduced the mortality rate when therapy was initiated 3 hr after challenge; however, the same quantity of poly I-poly C injected into the opposite leg did not reduce the mortality rate. The muscle injected with poly I-poly C invariably contained four to eight times more interferon than a similar noninjected muscle from the same animal. Mice treated 3 hr after challenge with each of the three vaccines produced significant levels of antibody but were not protected, whereas treatment with combinations of poly I-poly C and vaccine resulted in significant protection. These results suggest that the combination of induction of local interferon and an immune response contributes to the protection of mice after exposure to street rabies virus infection.

Title The Radiographic Presentation of Pulmonary Opportunistic Inflammatory Disease.
Date November 1973
Journal Radiologic Clinics of North America
Title The Roentgenographic Manifestations of Pulmonary Opportunistic Infections.
Date June 1973
Journal The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine
Title A New Method for Detecting Plasmodia.
Date January 1973
Journal Military Medicine
Title Rabies in Rabbits and Mice: Protective Effect of Polyriboinosinic-polyribocytidylic Acid.
Date June 1972
Journal The Journal of Infectious Diseases
Title Detection of Plasmodia by Acridine Orange Stain.
Date February 1969
Journal Technical Bulletin of the Registry of Medical Technologists
Title Providence Bacillus Bacteremia and Septicopyemia.
Date January 1969
Journal The American Journal of Medicine

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