Emergency Physician
9 years of experience

Education ?

Medical School Score Rankings
The University of Texas at Houston (2001)
  • Currently 3 of 4 apples
Top 50%

Awards & Distinctions ?

Associations
American Board of Emergency Medicine

Affiliations ?

Dr. Heflin is affiliated with 8 hospitals.

Hospital Affilations

Score

Rankings

  • Texas Health Harris Methodist Hospital Azle
    108 Denver Trl, Azle, TX 76020
    • Currently 3 of 4 crosses
    Top 50%
  • Harris Continued Care Hospital
    1301 Pennsylvania Ave, Fort Worth, TX 76104
  • Texas Health Harris Methodist Hospital Southwest Fort Worth
  • Usmd Surgical Hospital Of Arlington
  • Harris Methodist H E B
  • Arlington Memorial
  • Texas Health Arlington Memorial Hospital
  • Texas Health Presbyterian Hospital Of Dallas
  • Publications & Research

    Dr. Heflin has contributed to 1 publication.
    Title Heparin Reverses Anaphylactoid Shock in a Porcine Model.
    Date October 2006
    Journal Annals of Emergency Medicine
    Excerpt

    STUDY OBJECTIVE: Heparin binds histamine and has been advocated as a therapy for anaphylactic and anaphylactoid shock. The efficacy of heparin in treating anaphylactoid shock is compared with therapy with diphenhydramine and epinephrine, as well as sham treatment with saline. METHODS: This controlled study of 9 anesthetized, intubated pigs induced shock with intravenous calcium ionophore A23187 (5 mg/kg), which is known to degranulate mast cells in vitro. Serum histamine levels were measured using an enzyme-linked immunosorbent assay. Shock, defined as a greater than 20% decrease in mean arterial blood pressure, was treated with intravenous saline, epinephrine with diphenhydramine, or heparin. Data were analyzed using Wilcoxon rank sum and analysis of variance, as appropriate. RESULTS: All pigs developed anaphylactoid shock after injection with A23187, as evidenced by hypotension, flushing, and an increase in plasma histamine. Mean arterial blood pressure fell from a mean of 73 (SD 10) mm Hg to 28 (SD 16) mm Hg after injection (P<.001; 95% confidence interval [CI] of the difference in pressures 34 to 57 mm Hg). Mean serum histamine levels increased from 712 micromol/dL (SD 731) to 1,154 micromol/dL (SD 799) after injection (Z value -2.201; P=.0277; 95% CI of the difference -610 to -99). Both epinephrine with diphenhydramine and heparin but not saline reversed shock. CONCLUSION: A23187 induced anaphylactoid shock in all subjects. Therapy with intravenous epinephrine combined with diphenhydramine reversed shock. Heparin also rapidly reversed shock.

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