Browse Health
Pediatrician, Oncology Specialist (cancer), Pediatric Specialist
40 years of experience

Education ?

Medical School Score Rankings
University of Iowa (1970)
  • Currently 4 of 4 apples
Top 25%

Affiliations ?

Dr. Singer is affiliated with 4 hospitals.

Hospital Affilations

Score

Rankings

  • Phoenix Children's Hospital
    1919 E Thomas Rd, Phoenix, AZ 85016
    • Currently 3 of 4 crosses
    Top 50%
  • Banner Good Samaritan Regional Medical Center
    Medical Oncology
    1111 E McDowell Rd, Phoenix, AZ 85006
    • Currently 3 of 4 crosses
    Top 50%
  • Phx Childrens Hospital
  • St Josephs Hospital and Med Center
  • Publications & Research

    Dr. Singer has contributed to 12 publications.
    Title Health and Security in Foreign Policy.
    Date May 2007
    Journal Bulletin of the World Health Organization
    Title Involving Children with Cancer in Decision-making About Research Participation.
    Date February 2007
    Journal The Journal of Pediatrics
    Title Transmission of Infections During Commercial Air Travel.
    Date September 2005
    Journal Lancet
    Title Epidemic West Nile Encephalitis, New York, 1999: Results of a Household-based Seroepidemiological Survey.
    Date August 2001
    Journal Lancet
    Excerpt

    BACKGROUND: In the summer of 1999, West Nile virus was recognised in the western hemisphere for the first time when it caused an epidemic of encephalitis and meningitis in the metropolitan area of New York City, NY, USA. Intensive hospital-based surveillance identified 59 cases, including seven deaths in the region. We did a household-based seroepidemiological survey to assess more clearly the public-health impact of the epidemic, its range of illness, and risk factors associated with infection. METHODS: We used cluster sampling to select a representative sample of households in an area of about 7.3 km(2) at the outbreak epicentre. All individuals aged 5 years or older were eligible for interviews and phlebotomy. Serum samples were tested for IgM and IgG antibodies specific for West Nile virus. FINDINGS: 677 individuals from 459 households participated. 19 were seropositive (weighted seroprevalence 2.6% [95% CI 1.2-4.1). Six (32%) of the seropositive individuals reported a recent febrile illness compared with 70 of 648 (11%) seronegative participants (difference 21% [0-47]). A febrile syndrome with fatigue, headache, myalgia, and arthralgia was highly associated with seropositivity (prevalence ratio 7.4 [1.5-36.6]). By extrapolation from the 59 diagnosed meningoencephalitis cases, we conservatively estimated that the New York outbreak consisted of 8200 (range 3500-13000) West Nile viral infections, including about 1700 febrile infections. INTERPRETATION: During the 1999 West Nile virus outbreak, thousands of symptomless and symptomatic West Nile viral infections probably occurred, with fewer than 1% resulting in severe neurological disease.

    Title Risk Factors for Acquisition of Vancomycin-resistant Enterococci Among Patients on a Renal Ward During a Community Hospital Outbreak.
    Date October 2000
    Journal American Journal of Infection Control
    Excerpt

    During an outbreak of vancomycin-resistant enterococcal (VRE) infection and colonization at a community hospital in Indianapolis, Indiana, we performed a case-control study of patients on the hospital's renal unit to determine risk factors for acquisition of VRE among this potentially high-risk patient population.

    Title Transient Monosomy 7: a Case Series in Children and Review of the Literature.
    Date June 1999
    Journal Cancer
    Excerpt

    BACKGROUND: Monosomy 7 and deletions of the long arm of chromosome 7 [del (7q)] are recurrent, nonrandom chromosomal abnormalities associated with both de novo and therapy-related myelodysplastic syndromes (MDS). The overall prognosis for children and adults with these chromosomal abnormalities is poor. In the current report, the authors present five children with MDS associated with monosomy 7/del(7q) who achieved spontaneous hematologic disease remission as well as a review of the literature. METHODS: Five children with either de novo or treatment-related MDS who achieved spontaneous hematologic disease remission are presented. Relevant clinical, cytogenetic, and fluorescent in situ hybridization data are included. RESULTS: All patients were boys. Three had de novo MDS whereas two others previously had received chemotherapy for another malignancy. Four patients achieved spontaneous and durable hematologic disease remission that was associated with cytogenetic disease remission in all three patients tested. The fifth patient developed a disease recurrence and died with evidence of clonal evolution after a long interval of hematologic and cytogenetic remission. CONCLUSIONS: A subset of children who develop MDS associated with monosomy 7 or del(7q) achieve spontaneous hematologic and cytogenetic improvement. Although this appears to be uncommon, further data are needed to determine the percentage of patients who improve without therapy and to define clinical characteristics that may predict this clinical outcome. These findings suggest that monosomy 7/del(7q) is insufficient to produce full leukemic transformation.

    Title Control of Vancomycin-resistant Enterococci at a Community Hospital: Efficacy of Patient and Staff Cohorting.
    Date April 1999
    Journal Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America
    Excerpt

    To evaluate the efficacy of patient and staff cohorting to control vancomycin-resistant enterococci (VRE) at an Indianapolis community hospital.

    Title Pseudo-outbreak of Enterococcus Durans Infections and Colonization Associated with Introduction of an Automated Identification System Software Update.
    Date March 1997
    Journal Journal of Clinical Microbiology
    Excerpt

    Enterococci are an important cause of hospital-acquired infections. Since 1989, there has been an increase in the number of nosocomial enterococcal infections caused by strains resistant to vancomycin in the United States. Although many enterococcal species can colonize humans, only Enterococcus faecalis, E. faecium, E. raffinosus, and E. casseliflavus have been implicated in clusters of infection. In January 1996, the Centers for Disease Control and Prevention received a report of an outbreak of vancomycin-resistant enterococci in which 31 of 84 (36.9%) isolates were identified as E. durans. Twenty-nine isolates identified as E. durans were identified to the species level after the introduction of an automated identification system software update (Vitek gram-positive identification card, version R09.1) for the identification of species of gram-positive organisms. When seven isolates initially reported as E. durans were identified to the species level by alternate methods, they were found to be E. faecium. Subsequently, isolates identified as E. durans by the automated system were reidentified by using a rapid streptococcus test, and no further enterococcal isolate has been confirmed as E. durans. Automated microbial analysis is a potential source of error that is not easily recognized. When laboratory findings are discordant with expected clinical or epidemiologic patterns, confirmatory testing by alternate methods should be performed.

    Title Informed Consent for Bone Marrow Transplantation: Identification of Relevant Information by Referring Physicians.
    Date July 1991
    Journal Bone Marrow Transplantation
    Excerpt

    Two hundred Michigan hematologists-oncologists were sent a 34-item questionnaire designed to assess what patients should know at the time of giving consent to bone marrow transplant (BMT). Sixty-three (32%) responded to a single mailing and rated items on a 8-point scale, varying from 0 = no need to know to 7 = appreciation of consequences essential. The mean rating across items was 5.2, indicating that all items were important. Statistically, the items separated into three groups: (1) above average importance - 13 items; (2) average importance - 9 items; (3) below average importance - 12 items. Items of above average importance included the rationale for BMT and the collective risks and benefits of the process, including the patient's well-being post-transplant. Informed consent documents did not include 5/13 items of above average importance, yet 12/21 items of average and below average importance were included. Fourteen demographic variables were correlated with each item and none were significant, indicating that the ratings represent a broad consensus in the referring physician community as to what a patient should understand before consenting to BMT. The vast majority of referring physicians agreed that patients usually have an adequate understanding of BMT at the time of giving informed consent and that a fully informed patient is more likely to adhere to the treatment regimen.

    Title Iodine-125-mibg to Treat Neuroblastoma: Preliminary Report.
    Date October 1990
    Journal Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
    Excerpt

    Three children with Stage III neuroblastoma were treated with [125I]MIBG in a phase I toxicity study. Concepts of the treatment were: in small tumors, the absorbed dose of radiation from MIBG labeled with 131I is reduced but the absorbed dose from [125I]MIBG is less affected; and many recurrences of neuroblastoma arise from small tumors. Two patients exhibited only modest thrombocytopenia and leukopenia, the most sensitive indices of radiation toxicity, after receiving 261 and 407 mCi, and 83 and 104 rad of whole-body radiation. One patient died of progressive neuroblastoma; the other two patients have stable disease over 30 mo after treatment. Per millicurie given, [125I]MIBG imparts about one-fourth the radiation dose of [131I]MIBG to the whole body. Iodine-125-MIBG can be given in doses that impart over 100 rad of whole-body radiation and that exceed 400 mCi before toxicity becomes limiting, even in small children.

    Title Ampicillin-resistant Haemophilus Influenza in Nebraska.
    Date May 1982
    Journal The Nebraska Medical Journal
    Title Cefaclor--a Cluster of Adverse Reactions.
    Date November 1980
    Journal The New England Journal of Medicine

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