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Surgical Specialist, Cardiothoracic Surgeon
33 years of experience
Accepting new patients
Video profile


Education ?

Medical School Score Rankings
The University of Texas Southwestern (1979)
Top 25%

Awards & Distinctions ?

American College of Surgeons
Cardiothoracic Surgery Network
Society of Thoracic Surgeons
American Board of Thoracic Surgery

Affiliations ?

Dr. Carter is affiliated with 14 hospitals.

Hospital Affiliations



  • Texas Health Arlington Memorial Hospital
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    800 W Randol Mill Rd, Arlington, TX 76012
    Top 25%
  • Texas Health Harris Methodist Hospital Azle
    108 Denver Trl, Azle, TX 76020
    Top 50%
  • Texas Health Presbyterian Hospital Of Dallas
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    8200 Walnut Hill Ln, Dallas, TX 75231
    Top 50%
  • Harris Methodist H E B
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    1600 Hospital Pkwy, Bedford, TX 76022
    Top 50%
  • Texas Health Harris Methodist Hospital Southwest Fort Worth
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    6100 Harris Pkwy, Fort Worth, TX 76132
  • Baylor Medical Center At Irving
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    1901 N MacArthur Blvd, Irving, TX 75061
  • Las Colinas Medical Center
    Thoracic Surgery (Cardiothoracic Vascular Surgery)
    6800 N MacArthur Blvd, Irving, TX 75039
  • Texas Health HEB
  • Harris Methodist - Springwood
    1608 Hospital Pkwy, Bedford, TX 76022
  • Harris Heb Hospital
  • Harris Continued Care Hospital
    1301 Pennsylvania Ave, Fort Worth, TX 76104
  • TX Health Arlington
  • TX Health Fort Worth
  • TX Health Harris Methodist Hospital Hurst-Euless-Be
  • Publications & Research

    Dr. Carter has contributed to 30 publications.
    Title High-throughput Nanohole Array Based System to Monitor Multiple Binding Events in Real Time.
    Date June 2008
    Journal Analytical Chemistry

    We have developed an integrated label-free, real-time sensing system that is able to monitor multiple biomolecular binding events based on the changes in the intensity of extraordinary optical transmission (EOT) through nanohole arrays. The core of the system is a sensing chip containing multiple nanohole arrays embedded within an optically thick gold film, where each array functions as an independent sensor. Each array is a square array containing 10 x 10 nanoholes (150 nm in diameter), occupying a total area of 3.3 mum x 3.3 mum. The integrated system includes a laser light source, a temperature-regulated flow cell encasing the sensing chip, motorized optics, and a charge-coupled detector (CCD) camera. For demonstration purposes, sensing chips containing 25 nanohole arrays were studied for their use in multiplexed detection, although the sensing chip could be easily populated to contain up to 20 164 nanohole arrays within its 0.64 cm2 sensing area. Using this system, we successfully recorded 25 separate binding curves between glutathione S-transferase (GST) and anti-GST simultaneously in real time with good sensitivity. The system responds to binding events in a concentration-dependent manner, showing a sharp linear response to anti-GST at concentrations ranging from 13 to 290 nM. The EOT intensity-based approach also enables the system to monitor multiple bindings simultaneously and continuously, offering a temporal resolution on milliseconds scale that is decided only by the camera speed and exposure time. The small footprint of the sensing arrays combined with the EOT intensity-based approach enables the system to resolve binding events that occurred on nanohole sensing arrays spaced 96 mum apart, with a reasonable prediction of resolving binding events spaced 56 mum apart. This work represents a new direction that implements nanohole arrays and EOT intensity to meet high-throughput, spatial and temporal resolution, and sensitivity requirements in drug discovery and proteomics studies.

    Title A Biodegradable and Biocompatible Gecko-inspired Tissue Adhesive.
    Date March 2008
    Journal Proceedings of the National Academy of Sciences of the United States of America

    There is a significant medical need for tough biodegradable polymer adhesives that can adapt to or recover from various mechanical deformations while remaining strongly attached to the underlying tissue. We approached this problem by using a polymer poly(glycerol-co-sebacate acrylate) and modifying the surface to mimic the nanotopography of gecko feet, which allows attachment to vertical surfaces. Translation of existing gecko-inspired adhesives for medical applications is complex, as multiple parameters must be optimized, including: biocompatibility, biodegradation, strong adhesive tissue bonding, as well as compliance and conformability to tissue surfaces. Ideally these adhesives would also have the ability to deliver drugs or growth factors to promote healing. As a first demonstration, we have created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biocompatible surface coating. Tissue adhesion was optimized by varying dimensions of the nanoscale pillars, including the ratio of tip diameter to pitch and the ratio of tip diameter to base diameter. Coating these nanomolded pillars of biodegradable elastomers with a thin layer of oxidized dextran significantly increased the interfacial adhesion strength on porcine intestine tissue in vitro and in the rat abdominal subfascial in vivo environment. This gecko-inspired medical adhesive may have potential applications for sealing wounds and for replacement or augmentation of sutures or staples.

    Title Lateral Flow Microarrays: a Novel Platform for Rapid Nucleic Acid Detection Based on Miniaturized Lateral Flow Chromatography.
    Date June 2007
    Journal Nucleic Acids Research

    Widely used nucleic acid assays are poorly suited for field deployment where access to laboratory instrumentation is limited or unavailable. The need for field deployable nucleic acid detection demands inexpensive, facile systems without sacrificing information capacity or sensitivity. Here we describe a novel microarray platform capable of rapid, sensitive nucleic acid detection without specialized instrumentation. The approach is based on a miniaturized lateral flow device that makes use of hybridization-mediated target capture. The miniaturization of lateral flow nucleic acid detection provides multiple advantages over traditional lateral flow devices. Ten-microliter sample volumes reduce reagent consumption and yield analyte detection times, excluding sample preparation and amplification, of <120 s while providing sub-femtomole sensitivity. Moreover, the use of microarray technology increases the potential information capacity of lateral flow. Coupled with a hybridization-based detection scheme, the lateral flow microarray (LFM) enables sequence-specific detection, opening the door to highly multiplexed implementations for broad-range assays well suited for point-of-care and other field applications. The LFM system is demonstrated using an isothermal amplification strategy for detection of Bacillus anthracis, the etiologic agent of anthrax. RNA from as few as two B. anthracis cells was detected without thermocycling hardware or fluorescence detection systems.

    Title Inhibition of Akt by the Alkylphospholipid Perifosine Does Not Enhance the Radiosensitivity of Human Glioma Cells.
    Date October 2006
    Journal Molecular Cancer Therapeutics

    Akt has been implicated as a molecular determinant of cellular radiosensitivity. Because it is often constitutively activated or overexpressed in malignant gliomas, it has been suggested as a target for brain tumor radiosensitization. To evaluate the role of Akt in glioma radioresponse, we have determined the effects of perifosine, a clinically relevant alkylphospholipid that inhibits Akt activation, on the radiosensitivity of three human glioma cell lines (U87, U251, and LN229). Each of the glioma cell lines expressed clearly detectable levels of phosphorylated Akt indicative of constitutive Akt activity. Exposure to a perifosine concentration that reduced survival by approximately 50% significantly reduced the level of phosphorylated Akt as well as Akt activity. Cell survival analysis using a clonogenic assay, however, revealed that this Akt-inhibiting perifosine treatment did not enhance the radiosensitivity of the glioma cell lines. This evaluation was then extended to an in vivo model using U251 xenografts. Perifosine delivered to mice bearing U251 xenografts substantially reduced tumor phosphorylated Akt levels and inhibited tumor growth rate. However, the combination of perifosine and radiation resulted in a less than additive increase in tumor growth delay. Thus, in vitro and in vivo data indicate that the perifosine-mediated decrease in Akt activity does not enhance the radiosensitivity of three genetically disparate glioma cell lines. These results suggest that, although Akt may influence the radiosensitivity of other tumor types, it does not seem to be a target for glioma cell radiosensitization.

    Title In Vitro and in Vivo Radiosensitization Induced by the Ribonucleotide Reductase Inhibitor Triapine (3-aminopyridine-2-carboxaldehyde-thiosemicarbazone).
    Date August 2006
    Journal Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

    PURPOSE: Because ribonucleotide reductase (RR) plays a role in DNA repair, it may serve as a molecular target for radiosensitization. Unlike previously investigated RR inhibitors, Triapine potently inhibits both RR holoenzymes. Therefore, the effects of Triapine on tumor cell radiosensitivity were investigated. EXPERIMENTAL DESIGN: The effects of Triapine on the in vitro radiosensitivity of three human tumor cell lines and one normal cell line were evaluated using a clonogenic assay. Growth delay was used to evaluate the effects of Triapine on in vivo tumor radiosensitivity. The levels of the RR subunits were determined using immunoblot analysis and DNA damage and repair were evaluated using gammaH2AX foci. RESULTS: Exposure of the tumor cell lines to Triapine before or immediately after irradiation resulted in an increase in radiosensitivity. In contrast, Triapine enhanced the radiosensitivity of the normal fibroblast cell line only when the exposure was before irradiation. There were no consistent differences between cell lines with respect to the expression of the RR subunits. Whereas Triapine had no effect on radiation-induced gammaH2AX foci at 1 hour, the number of gammaH2AX foci per cell was significantly greater in the Triapine-treated cells at 24 hours after irradiation, suggesting the presence of unrepaired DNA damage. Triapine administration to mice bearing tumor xenografts immediately after irradiation resulted in a greater than additive increase in radiation-induced tumor growth delay. CONCLUSIONS: These results indicate that Triapine can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect involves an inhibition of DNA repair.

    Title Enhancement of in Vitro and in Vivo Tumor Cell Radiosensitivity by the Dna Methylation Inhibitor Zebularine.
    Date August 2005
    Journal Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

    Aberrant DNA hypermethylation is a frequent finding in tumor cells, which has suggested that inhibition of DNA methylation may be an effective cancer treatment strategy. Because DNA methylation affects gene expression and chromatin structure, parameters considered to influence radioresponse, we investigated the effects of the DNA methylation inhibitor zebularine on the radiosensitivity of human tumor cells. Three human tumor cell lines were used in this study (MiaPaCa, DU145, and U251) and the methylation status of three genes frequently hypermethylated in tumor cells (RASSF1A, HIC-1, and 14-3-3sigma) was determined as a function of zebularine exposure. Zebularine resulted in DNA demethylation in a time-dependent manner, with the maximum loss of methylation detected by 48 hours. Treatment of cells with zebularine for 48 hours also resulted in an increase in radiosensitivity with dose enhancement factors of >1.5. As a measure of radiation-induced DNA damage, gammaH2AX expression was determined. Whereas zebularine had no effect on radiation-induced gammaH2AX foci at 1 hour, the number of gammaH2AX foci per cell was significantly greater in the zebularine-treated cells at 24 hours after irradiation, suggesting the presence of unrepaired DNA damage. Zebularine administration to mice reactivated gene expression in U251 xenografts; irradiation of U251 tumors in mice treated with zebularine resulted in an increase in radiation-induced tumor growth delay. These results indicate that zebularine can enhance tumor cell radiosensitivity in vitro and in vivo and suggest that this effect may involve an inhibition of DNA repair.

    Title Enhanced Tumor Cell Radiosensitivity and Abrogation of G2 and S Phase Arrest by the Hsp90 Inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.
    Date April 2005
    Journal Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

    PURPOSE: Because of the potential for affecting multiple signaling pathways, inhibition of Hsp90 may provide a strategy for enhancing tumor cell radiosensitivity. Therefore, we have investigated the effects of the orally bioavailable Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG) on the radiosensitivity of human tumor cells in vitro and grown as tumor xenografts. EXPERIMENTAL DESIGN: The effect of 17-DMAG on the levels of three proteins (Raf-1, ErbB2, and Akt) previously implicated in the regulation of radiosensitivity was determined in three human solid tumor cell lines. A clonogenic assay was then used to evaluate cell survival after exposure to 17-DMAG followed by irradiation. For mechanistic insight, the G(2)- and S-phase checkpoints were evaluated in 17-DMAG-treated cells. Finally, the effect of in vivo administration of 17-DMAG in combination with radiation on the growth rate of xenograft tumors was determined. RESULTS: 17-DMAG exposure reduced the levels of the three radiosensitivity-associated proteins in a cell line-specific manner with ErbB2 being the most susceptible. Corresponding concentrations of 17-DMAG enhanced the radiosensitivity of each of the tumor cell lines. This sensitization seemed to be the result of a 17-DMAG-mediated abrogation of the G(2)- and S-phase cell cycle checkpoints. The oral administration of 17-DMAG to mice bearing tumor xenografts followed by irradiation resulted in a greater than additive increase in tumor growth delay. CONCLUSIONS: These data indicate that 17-DMAG enhances the in vitro and in vivo radiosensitivity of human tumor cells. The mechanism responsible seems to involve the abrogation of radiation-induced G(2)- and S-phase arrest.

    Title East Meets West: Integrating Psychotherapy Approaches for Muslim Women.
    Date August 2004
    Journal Holistic Nursing Practice

    Psychotherapists' knowledge and understanding of Muslim women's culture is essential for them to effectively treat patients. Muslim women's culture is based on Islam, which permeates their thinking patterns, their interaction with themselves and others, and all activities of their daily lives. Western psychotherapy ineffectively treats Muslim women because its individualistic and fragmented method is contrary to the Muslim population's holistic spiritual approach to life. This article provides a theoretical integration of Eastern and Western therapeutic concepts for Muslim women, to promote a more effective therapeutic approach for this population residing in the United States.

    Title Severe, Generalized Nummular Eczema Secondary to Interferon Alfa-2b Plus Ribavirin Combination Therapy in a Patient with Chronic Hepatitis C Virus Infection.
    Date March 2004
    Journal Archives of Dermatology

    BACKGROUND: With increasing rates of hepatitis C virus infection and diagnosis, more patients are being treated with interferon alfa-2b plus ribavirin therapy. Cutaneous side effects to combination therapy are common and may limit treatment. There are few previous case reports of generalized eczematous dermatoses occurring after combination therapy for hepatitis C virus, none in a North American patient, and none of this severity or recalcitrance. OBSERVATIONS: A man with chronic hepatitis C virus infection and no history of atopy developed severe, recalcitrant nummular eczema secondary to interferon alfa-2b plus ribavirin combination therapy. The cutaneous side effect was more severe than in previously reported cases and did not remit on discontinuation of therapy. CONCLUSIONS: Greater awareness of the range of dermatologic responses to interferon alfa-2b plus ribavirin therapy may lead to improved surveillance for and treatment of these side effects. Investigating the underlying pathologic mechanisms may ultimately allow for a greater understanding of the immunomodulatory effects of this therapy in the setting of chronic hepatitis C virus infection.

    Title Theoretical Model of Psychotherapy: Eastern Asian-islamic Women with Mental Illness.
    Date September 2003
    Journal Health Care for Women International

    The Muslim immigrant population is increasing in the United States. To provide appropriate psychotherapy for this group, especially Islamic women, treatment professionals must have a deeper understanding of the culture of Eastern Islamic women. Islam is the lifestyle of this population and it influences their thinking, the relationships among themselves and with others, and all other activities of daily life. The holistic approach of the Eastern Islamic population is incompatible with the individualistic approach of Western psychotherapy in treating Islamic women. We explore a theoretical model of psychotherapy for Eastern Asian-Islamic women suffering from mental illness (MI) to develop an effective and appropriate therapy. Health care providers, specifically those dealing with MI patients, will gain insights from the suggested psychotherapeutic model and its relevance to Islamic concepts and practices.

    Title Methoxsalen Stimulates Electrogenic Cl- Secretion in the Mouse Jejunum.
    Date March 2003
    Journal Experimental Physiology

    We used the short-circuit current (I(sc)) and patch-clamp techniques to investigate the effects of methoxsalen (MTX) on the electrogenic Cl- secretion of the mouse jejunum. MTX stimulated a sustained increase in Isc that was dose dependent. Bumetanide inhibited MTX-stimulated Isc in a dose-dependent manner consistent with activation of Cl- secretion. MTX failed to stimulate I(sc) following maximal activation of the cAMP pathway by forskolin, but did increase Isc after a submaximal dose of forskolin. Glibenclamide, a blocker of the cystic fibrosis transmembrane conductance regulator (CFTR), reduced the MTX-stimulated increase of Isc by 59 +/- 6%. The cAMP-dependent K+ channel blocker 293B did not alter the MTX-activated I(sc); however, clotrimazole, an intermediate Ca2(+)-activated K+ channel (IK(Ca)) blocker, reduced the MTX-stimulated I(sc). MTX did not alter Na(+)-glucose cotransport across the mouse jejunum. In cell-attached membrane patches, MTX increased the open probability of the basolateral IK(Ca) channel of isolated crypts. These data suggest that the CFTR and IK(Ca) channels participate in the MTX-activated, sustained Cl- secretory response of the mouse jejunum.

    Title Endogenously Expressed Estrogen Receptor and Coactivator Aib1 Interact in Mcf-7 Human Breast Cancer Cells.
    Date January 2001
    Journal Proceedings of the National Academy of Sciences of the United States of America

    Coactivators are believed to mediate estrogen-induced gene responses via interaction with estrogen receptors (ER). Currently, a major challenge is to determine the importance of each coactivator in a specific cell type and promoter context in response to a particular ligand. The potential of ER to interact with a growing list of coactivators has been shown in a variety of in vitro and gene transfer assays, yet very few data have demonstrated the interaction of endogenous coactivators with ER in intact cells. We report here a ligand-specific interaction of endogenous human ER (hER) and the AIB1 coactivator in MCF-7 human breast cancer cells by using immunoprecipitation analyses. Complexes between endogenously expressed hER and AIB1 were detected in estradiol-treated cells and to a much lesser extent in cells treated with the partial agonist, monohydroxytamoxifen. We were unable to detect an hER-SRC-1 complex in our immunoprecipitations from MCF-7 cells. The in vitro-binding affinity for mouse ER interaction with AIB1 was estimated to be 40-120 nM. We conclude that AIB1 is a major coactivator for hER in MCF-7 human breast cancer cells.

    Title Biological-to-electronic Interface with Pores of Atp Synthase Subunit C in Silicon Nitride Barrier.
    Date June 2000
    Journal Medical & Biological Engineering & Computing

    An oscillator pore is identified that generates intermittent, large amplitude, ionic current in the plasma membrane. The pore is thought to be composed of 10-12 units of subunit c of ATP synthase. Pore opening and closing is a co-operative process, dependent on the release, or binding, of as many as six calcium ions. This mechanism suggests a more general method of co-operative threshold detection of chemical agents via protein modification, the output being directly amplified in a circuit. Here the authors describe steps in the development of a sensor of chemical agents. The subunit c pore in a lipid bilayer spans a nanometer-scale hole in a silicon nitride barrier. Either side of the barrier are electrolyte solutions and current through the pore is amplified by circuitry. The techniques of laser ablation, electron beam lithography and ion beam milling are used to make successively smaller holes to carry the lipid patch. Holes of diameter as small as 20 nm are engineered in a silicon nitride barrier and protein activity in lipid membranes spanning holes as small as 30 nm in diameter is measured. The signal-to-noise ratio of the ionic current is improved by various measures that reduce the effective capacitance of the barrier. Some limits to scale reduction are discussed.

    Title Factor V Leiden and Pulmonary Embolism in a Young Woman Taking an Oral Contraceptive.
    Date March 1999
    Journal The American Journal of Forensic Medicine and Pathology : Official Publication of the National Association of Medical Examiners

    A 34-year-old woman with a history of asthma and oral contraceptive use died suddenly. Autopsy examination showed chronic pulmonary emboli with an acute pulmonary saddle embolus. An underlying congenital thrombophilic disorder was considered. Molecular studies on DNA isolated from blood using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis revealed coagulation factor V Leiden mutation. The incidence of venous thromboembolism in patients with factor V Leiden mutation and associated activated protein C (APC) resistance is discussed.

    Title Effects of 2 Mg and 4 Mg Atropine Sulfate on the Performance of U.s. Army Helicopter Pilots.
    Date November 1992
    Journal Aviation, Space, and Environmental Medicine

    Atropine autoinjectors are issued to aviators for use in the event of organophosphate poisoning on the battlefield. This investigation assessed the effects of unchallenged 2 mg and 4 mg doses on flight performance, vision, tracking, cognitive performance, and electroencephalograms of 12 Army aviators. Effects were seen most often with the 4 mg dose in terms of aircraft control problems, vision disturbances, impaired tracking, reduced cortical activation, and decreased cognitive skill. These problems indicate helicopter tactical flight is dangerous after an unchallenged 4 mg dose. Other types of flight should also be avoided for at least 12 h after atropine.

    Title Atypical Apocrine Metaplasia in Sclerosing Lesions of the Breast: a Study of 51 Patients.
    Date May 1991
    Journal Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc

    Sclerosing breast lesions with cytologically atypical apocrine metaplasia present a difficult diagnostic problem. The clinical significance of these lesions has not been established although, historically, apocrine metaplasia and sclerosing adenosis have been regarded as totally benign. To further assess these lesions, we studied 51 patients with atypical apocrine metaplasia in sclerosing lesions of the breast, obtaining an average follow-up of 35 mo (12 to 76 mo). For convenience, these have been grouped together as atypical apocrine sclerosing lesions (AASL). The average age at diagnosis was 58 yr. The lesions tended to be small (67% less than 1.0 cm) and usually were detected by mammography (78%). Four patients had an ipsilateral mastectomy following a biopsy of AASL that was interpreted as carcinoma or "precancerous" by the referring pathologist. Two patients had nonapocrine intraductal and infiltrating duct carcinoma in previous contralateral mastectomy specimens. None of the 47 women with an intact breast developed breast carcinoma during the follow-up period. Immediate treatment with surgery and/or radiation is not indicated. The long-term clinical implication of these lesions is yet to be determined; therefore, continued clinical observation of AASL patients is advisable.

    Title Radiology Pathology Conference. An 18-year-old Man with a 4-month History of Progressive Neck and Right Shoulder Pain.
    Date May 1990
    Journal Clinical Imaging
    Title Correlation of Computed Tomography and Postmortem Findings of a Diffuse Astrocytoma: a Case Report.
    Date February 1990
    Journal Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society

    Diffusely infiltrating astrocytomas often present diagnostic difficulties. We herein correlate the radiologic and postmortem findings of a diffuse astrocytoma and conclude that recognition of abnormal bilateral and fairly symmetric enlargement and increased density of normal structures in CT scans may lead to an antemortem diagnosis of the tumor.

    Title A Modified Extrathoracic Approach to the Treatment of Dysphagia Lusoria.
    Date October 1989
    Journal Journal of Vascular Surgery : Official Publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter

    The management of patients with esophageal compression by an anomalous right subclavian artery (dysphagia lusoria) has been controversial. A classic approach involves left thoracotomy, with resection of the aberrant subclavian artery from its origin to the right border of the esophagus. To prevent possible ischemic complications, most surgeons favor revascularization of the distal subclavian artery. Thoracotomy has been the traditional approach for division or reimplantation of the aberrant right subclavian artery. We describe a modification (right supraclavicular incision) of an extrathoracic approach, which was first described by Orvald in 1972, to simplify simultaneous correction of dysphagia lusoria and revascularization of the right upper extremity.

    Title System for Long-term Review of Patients at Risk of Becoming Hypothyroid. Further Experience.
    Date December 1977
    Journal Lancet

    8 years' experience of a computer-assisted system for long-term follow-up of patients at risk of hypothyroidism shows that the system is reliable, efficient, and economical. Less than 0.1% of registered patients are now lost to follow-up and less than 2% of patients need to be seen by the medical staff each year. Changes have been made in registration procedures and in the methods of finding patient who fail to attend. Improvements in the laboratory screening of thyroid function have also been introduced. The need to follow-up patients already under treatment with thyroxine has been recognised and the importance of a reliable system is reaffirmed.

    Title The Effect of Treatment of Hyper- and Hypothyroidism on Urinary Excretion of Cyclic Adenosine 3',5'-monophosphate.
    Date April 1977
    Journal Acta Endocrinologica

    The urinary excretion of cyclic adenosine 3',5'-monophosphate (cyclic AMP) was examined in patients with hyperthyroidism and primary hypothyroidism, before treatment and at least six months later on return to euthyroid status. Urinary cyclic AMP excretion was significantly greater in the hyperthyroid group than in the hypothyroid group both in the basal state (P less than 0.01) and the ambulant state (P less than 0.001). In ambulant hyperthyroid patients absolute urinary cyclic AMP excretion (mumol/24 h) was significantly greater (P less than 0.05) prior to treatment than on return to euthyroid status. In the hypothyroid group no significant change occurred after treatment with 1-thyroxine (P greater than 0.05). The mechanism of changes in urinary cyclic AMP excretion in thyroid disease are discussed.

    Title Arterial Surgery in Pseudoxanthoma Elasticum.
    Date October 1976
    Journal Postgraduate Medical Journal
    Title Letter: Spontaneous Pneumococcal Peritonitis.
    Date October 1975
    Journal British Medical Journal
    Title Proceedings. Urinary Cyclic Amp Excretion in Thyroid Disease.
    Date March 1975
    Journal Clinical Science and Molecular Medicine
    Title Opening Address: 47th Annual Conference, New Zealand Veterinary Association.
    Date November 1971
    Journal New Zealand Veterinary Journal
    Title The Great Illusion Controversy: a Glimpse.
    Date June 1969
    Journal Perceptual and Motor Skills
    Title Subjective Median Plane As a Function of Age and Source of Stimulation.
    Date April 1968
    Journal Perceptual and Motor Skills
    Title Neurosyphilis Associated with Haematemesis: Report of a Case.
    Date February 1968
    Journal The British Journal of Clinical Practice
    Title Connotations of Racial Concepts and Color Names in Germany.
    Date November 1967
    Journal The Journal of Social Psychology
    Title Further Test of Deprivation Trace Hypothesis.
    Date November 1965
    Journal Psychological Reports

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