Ophthalmologist, Retina
11 years of experience
Video profile
Accepting new patients
Med Center
4860 Y St
Suite 2400
Sacramento, CA 95817
916-734-6602
Locations and availability (6)

Education ?

Medical School Score Rankings
University of Minnesota, Twin Cities (1999)
  • Currently 4 of 4 apples
Top 25%

Awards & Distinctions ?

Awards  
Castle Connolly's Top Doctors™ (2013)
Patients' Choice 5th Anniversary Award (2012)
Patients' Choice Award (2008 - 2012)
Compassionate Doctor Recognition (2010, 2012)
American Academy of Ophthalmology *
American Registry *
Appointments
Univ. of California, Davis (2005 - Present)
Assist Professor
Associations
American Board of Ophthalmology
American Society of Retina Specialists
American Academy of Ophthalmology

Affiliations ?

Dr. Telander is affiliated with 7 hospitals.

Hospital Affilations

Score

Rankings

  • Sutter Roseville Medical Center
    1 Medical Plaza Dr, Roseville, CA 95661
    • Currently 4 of 4 crosses
    Top 25%
  • Sutter General Hospital
    2801 L St, Sacramento, CA 95816
    • Currently 4 of 4 crosses
    Top 25%
  • Methodist Hospital of Sacramento
    7500 Hospital Dr, Sacramento, CA 95823
    • Currently 2 of 4 crosses
  • University of California Davis Medical Center
  • Sutter Medical Center- Sacramento
    5151 F St, Sacramento, CA 95819
  • UC Davis Medical Center
  • Memorial Medical Center Modesto
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Telander has contributed to 18 publications.
    Title Epithelial Membrane Protein-2 (emp2) and Experimental Proliferative Vitreoretinopathy (pvr).
    Date September 2011
    Journal Current Eye Research
    Excerpt

    Proliferative vitreoretinopathy (PVR) is believed to result in part from de-differentiation of retinal pigment epithelium (RPE) with cellular migration in the vitreous cavity, membrane formation, and contraction in an aberrant wound-healing strategy. In an in vitro collagen-gel contraction assay, epithelial membrane protein 2 (EMP2) controls contraction through activation of focal adhesion kinase (FAK) in a RPE cell line (ARPE-19). The purpose of this study was to investigate how blocking or altering the level of EMP2 expression changed clinical PVR in an in vivo model.

    Title B-cell Lymphoma Line (raji) Viability and Surface Marker Expression Minimally Affected by 20- and 25-gauge Vitrectomy Systems Analyzed by Flow Cytometry.
    Date December 2010
    Journal Retina (philadelphia, Pa.)
    Excerpt

    The purpose of this study was to evaluate the effect of 20-gauge (20-G) and 25-gauge (25-G) vitrectomy on cell viability and diagnostic yield (surface marker expression) using flow cytometry and human lymphoma cells in culture.

    Title High-resolution Fourier-domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-related Macular Degeneration.
    Date August 2010
    Journal Investigative Ophthalmology & Visual Science
    Excerpt

    To investigate the use of high-resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVMs) associated with exudative age-related macular degeneration (eAMD).

    Title Comparison of Macular Thickness Measurement and Segmentation Error Rate Between Stratus and Fourier-domain Optical Coherence Tomography.
    Date July 2010
    Journal Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
    Excerpt

    To compare macular thickness measurements and segmentation error rates between Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Inc., Dublin, CA), and Fourier-domain OCT (RTVue, Optovue, Inc., Fremont, CA).

    Title High Resolution Fourier-domain Optical Coherence Tomography of Retinal Angiomatous Proliferation.
    Date November 2007
    Journal Retina (philadelphia, Pa.)
    Excerpt

    PURPOSE: To study the anatomic details of retinal angiomatous proliferation (RAP) in patients with age-related macular degeneration (AMD) using high-resolution Fourier-domain optical coherence tomography (Fd-OCT) and its three-dimensional reconstructions. METHODS: A Fd-OCT instrument was used to image five patients clinically diagnosed with RAP. A series of 100 raster-scanned B-scans centered over the macula was registered and rendered as a three-dimensional volume. These retinal structures were analyzed for anatomic details of the RAP lesions. RESULTS: The RAP lesion could be identified within the retina on Fd-OCT in all five cases. Fd-OCT images of the first four cases revealed areas of intraretinal neovascularization (IRN) in the deep retina adjacent to a pigment epithelial detachment (PED). There was neovascular proliferation anteriorly and posteriorly through a break in the retinal pigment epithelium (RPE). In three of the four cases, Bruch membrane remained intact. There was no identifiable choroidal neovascularization (CNV). The fifth case had both subretinal and sub-RPE neovascular membranes without a PED. CONCLUSION: Fd-OCT provides unprecedented in vivo detail of the anatomy of RAP lesions that nearly resembles histologic specimens. This study suggests that the initial neovascular process in RAP can originate either within the retina or in the sub-RPE space.

    Title Cystoid Macular Edema with Docetaxel Chemotherapy and the Fluid Retention Syndrome.
    Date November 2007
    Journal Seminars in Ophthalmology
    Excerpt

    Docetaxel (Taxotere) is an anticancer agent used to treat a wide range of malignancies including breast, lung, and prostate cancer. In this report, we describe a patient with bilateral vision loss due to cystoid macular edema (CME) associated with docetaxel therapy. This report documents for the first time the optical coherence tomography (OCT) findings of CME despite the lack of leakage with flourescein angiography and its association with the Fluid Retention Syndrome (FRS). Successful management of CME with oral acetazolamide is also discussed.

    Title Rubeosis and Anterior Segment Ischemia Associated with Systemic Cryoglobulinemia.
    Date October 2006
    Journal American Journal of Ophthalmology
    Excerpt

    PURPOSE: To report two cases of iris neovascularization associated with systemic cryoglobulinemia. DESIGN: Retrospective case report. METHODS: Patient chart review and review of literature. RESULTS: Two patients with iris neovascularization in the absence of retinal ischemia were subsequently found to have systemic cryoglobulinemia. Successful treatment of one patient's underlying lymphoma led to stabilization and resolution of neovascularization. CONCLUSIONS: Systemic cryoglobulinemia may be associated with anterior segment ischemia and neovascularization, and should be considered in the differential diagnosis of iris neovascularization in the absence of apparent retinal ischemia.

    Title Easy and Effective Way to Remove Residual Silicone Oil Droplets in Phakic Patients.
    Date August 2006
    Journal Retina (philadelphia, Pa.)
    Title Subconjunctival Corticosteroids for Benign Lymphoid Hyperplasia.
    Date July 2005
    Journal The British Journal of Ophthalmology
    Title Systemic Aspergillus Presenting with Visual Symptoms.
    Date May 2004
    Journal Retina (philadelphia, Pa.)
    Title Eye Injuries in the Young Athlete: a Case-based Approach.
    Date September 2002
    Journal Pediatric Annals
    Title Relaxed Negative Selection in Germinal Centers and Impaired Affinity Maturation in Bcl-xl Transgenic Mice.
    Date August 1999
    Journal The Journal of Experimental Medicine
    Excerpt

    The role of apoptosis in affinity maturation was investigated by determining the affinity of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific antibody-forming cells (AFCs) and serum antibody in transgenic mice that overexpress a suppressor of apoptosis, Bcl-xL, in the B cell compartment. Although transgenic animals briefly expressed higher numbers of splenic AFCs after immunization, the bcl-xL transgene did not increase the number or size of germinal centers (GCs), alter the levels of serum antibody, or change the frequency of NP-specific, long-lived AFCs. Nonetheless, the bcl-xL transgene product, in addition to endogenous Bcl-xL, reduced apoptosis in GC B cells and resulted in the expansion of B lymphocytes bearing VDJ rearrangements that are usually rare in primary anti-NP responses. Long-lived AFCs bearing these noncanonical rearrangements were frequent in the bone marrow and secreted immunoglobulin G(1) antibodies with low affinity for NP. The abundance of noncanonical cells lowered the average affinity of long-lived AFCs and serum antibody, demonstrating that Bcl-xL and apoptosis influence clonal selection/maintenance for affinity maturation.

    Title Evidence for Repression of Il-2 Gene Activation in Anergic T Cells.
    Date April 1999
    Journal Journal of Immunology (baltimore, Md. : 1950)
    Excerpt

    The induction of clonal anergy in a T cell inhibits IL-2 secretion because of the development of a proximal signal transduction defect. Fusion of anergic murine T cells to human Jurkat T leukemia cells and formation of heterokaryons failed to result in a complementation of this signaling defect and restoration of murine IL-2 mRNA inducibility. Instead, signal transduction to the human IL-2 gene became disrupted. Heterokaryons formed by the fusion of anergic murine T cells to normal murine T cells also failed to accumulate intracellular IL-2 protein in response to stimulation either with the combination of CD3 and CD28 mAbs or with ionomycin plus a protein kinase C-activating phorbol ester. The results argue against a loss-of-function signaling defect as the sole basis for clonal anergy induction and document the presence of a dominant-acting repressor molecule that inhibits signal transduction to the IL-2 gene within viable anergic T cells.

    Title The Role of Clonal Anergy in the Avoidance of Autoimmunity: Inactivation of Autocrine Growth Without Loss of Effector Function.
    Date March 1999
    Journal Immunological Reviews
    Excerpt

    Exposure of mature CD4+ T cells in the peripheral immune system to peptide-antigen/MHC complexes in the absence of a threat of infection induces tolerance to the antigen as a result of both a decreased clonal frequency (peripheral deletion) and the induction of proliferative unresponsiveness (clonal anergy) in the survivors. Interestingly, Th 1-like effector functions are not automatically blocked after the development of clonal anergy. Thus, anergic T cells have the capacity to mediate Th 1-like helper activities if allowed to accumulate to high frequency. In this article, we examine those factors important to the development of tolerance versus immunity against protein antigen, and speculate on the relationship that exists between effective peripheral tolerance induction and the avoidance of autoimmune disease.

    Title Impaired Lymphokine Secretion in Anergic Cd4+ T Cells Leads to Defective Help for B Cell Growth and Differentiation.
    Date June 1997
    Journal Journal of Immunology (baltimore, Md. : 1950)
    Excerpt

    The ability of anergic helper T cells to interact with resting B cells was examined in vitro. B cell growth and differentiation in cocultures were found to be dependent on the expression of CD40 ligand (CD40L) on the cloned T cells, and the expression of this molecule was only marginally blocked by the induction of anergy. In contrast, secretion of IL-3, IL-4, IL-5, and IL-6 within the cocultures was found to be significantly reduced following the induction of anergy, and this correlated with the development of a 3- to 10-fold decrease in the ability of the T cells to induce B cell proliferation and IgG secretion. In contrast to the B cells, the activation of the T cells in these cocultures did not result in proliferation; thus, the effects of T cell anergy observed on the B cell responses were independent of an ability of clonal anergy to block T cell clonal expansion. In one T cell clone (E6), lymphokine production was reduced in part because of an increased propensity to undergo apoptosis; nevertheless, two other clones (A.E7 and 16B.2) showed no reduced viability after anergy induction. Finally, the addition of rIL-2 to the anergic T cells significantly improved their helper activity relative to control cells; this was associated with a partial reversal of the IL-3, - 4, and -5 production defects. Therefore, clonal anergy can interfere with the delivery of helper lymphokines by T cells, resulting in a decreased capacity to stimulate the growth and differentiation of B cells.

    Title High-resolution Fourier-domain Optical Coherence Tomography and Microperimetric Findings After Macula-off Retinal Detachment Repair.
    Date
    Journal Ophthalmology
    Excerpt

    OBJECTIVE: To evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1). DESIGN: Prospective observational case series. PARTICIPANTS: Seventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant maculopathy on funduscopy. METHODS: FD OCT with axial and transverse resolution of 4.5 mum and 10 to 15 mum, respectively, was used to obtain rapid serial B-scans of the macula, which were compared with that from Stratus OCT. The FD OCT B-scans were used to create a 3-dimensional volume, from which en face C-scans were created. Among 11 patients, MP-1 was performed to correlate morphologic changes with visual function. MAIN OUTCOME MEASURES: Stratus OCT scans, FD OCT scans, and MP-1 data. RESULTS: Stratus OCT and FD OCT images of the macula were obtained 3 to 30 months (mean 7 months) postoperatively in all eyes. Although Stratus OCT revealed photoreceptor disruption in 2 eyes (12%), FD OCT showed photoreceptor disruption in 13 eyes (76%). This difference was statistically significant (P<0.001, chi(2)). Both imaging modalities revealed persistent subretinal fluid in 2 eyes (12%) and lamellar hole in 1 eye. Among 7 subjects who had reliable MP-1 data, areas of abnormal function corresponded to areas of photoreceptor layer disruptions or persistent subretinal fluid in 5 subjects (71%); one subject had normal FD OCT and MP-1. CONCLUSIONS: Photoreceptor disruption after macula-off RD repair is a common abnormality in the macula that is detected better with FD OCT than Stratus OCT. A good correlation between MP-1 abnormality and presence of photoreceptor disruption or subretinal fluid on FD OCT demonstrates that these anatomic abnormalities contribute to decreased visual function after successful repair.

    Title Microstructural Abnormalities Revealed by High Resolution Imaging Systems in Central Macular Arteriovenous Malformation.
    Date
    Journal Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
    Excerpt

    Using high-resolution spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging, photoreceptor damage in a patient with a central macular arteriovenous malformation (AVM) and otherwise unexplained progressive vision loss was demonstrated. This patient presented with a central scotoma, a macular AVM, and no evidence of macular edema, retinal hemorrhage, or subretinal fluid. Fluorescein angiography (FA) did not reveal leakage. Over 28 years, her vision progressively worsened from 20/25 to 20/400. Both time-domain OCT and FA did not reveal any significant retinal abnormality. However, high-resolution SD-OCT imaging revealed clear disorganization of the outer segments and focal photoreceptor disruption adjacent to the AVM. En face AO images further revealed loss of the photoreceptors in these regions. This case demonstrates the unique finding of progressive vision loss in a patient with a congenital retinal AVM, and how high-resolution imaging can detect structural changes of the retina in patients with otherwise unexplained vision loss.

    Title Bacterial Contamination of Needles Used for Intravitreal Injections: a Prospective, Multicenter Study.
    Date
    Journal Ocular Immunology and Inflammation
    Excerpt

    To determine the incidence of bacterial contamination of needles used for intravitreal injections.

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