Radiologist, Pediatric Specialist
7 years of experience

Fenway - Kenmore - Audubon Circle - Longwood
Children's Hospital
300 Longwood Ave
Boston, MA 02115
617-355-6286
Locations and availability (2)

Education ?

Medical School Score Rankings
Washington University at St. Louis (2003)
  • Currently 4 of 4 apples
Top 25%

Awards & Distinctions ?

Associations
American Board of Radiology

Affiliations ?

Dr. Jarrett is affiliated with 3 hospitals.

Hospital Affilations

Score

Rankings

  • Massachusetts General Hospital
    55 Fruit St, Boston, MA 02114
    • Currently 4 of 4 crosses
    Top 25%
  • Children's Hospital
    300 Longwood Ave, Boston, MA 02115
    • Currently 2 of 4 crosses
  • Children`s Hospital Boston
  • Publications & Research

    Dr. Jarrett has contributed to 6 publications.
    Title Unilateral Subtalar Coalition: Contralateral Sustentaculum Tali Morphology.
    Date January 2011
    Journal Radiology
    Excerpt

    PURPOSe: To measure and compare the dimensions of the sustentaculum tali (ST) in pediatric patients with unilateral subtalar coalition to determine if the contralateral side has altered morphology.

    Title Axial Oblique Ct to Assess Femoral Anteversion.
    Date May 2010
    Journal Ajr. American Journal of Roentgenology
    Excerpt

    OBJECTIVE: The objective of our study was to compare anteversion measurements of a human cadaveric femur obtained using axial CT slices with axial oblique reformations along the femoral neck and assess how accuracy changes across a range of simulated femur positions. CONCLUSION: Axial oblique reformations allow more accurate anteversion assessment than axial images with femoral flexion, extension, and internal and external rotation. Centers should consider replacing the standard straight axial technique with the axial oblique method for CT determination of femoral anteversion.

    Title Intrafamilial Phenotypic Variability in Tuberous Sclerosis Complex.
    Date March 2008
    Journal Journal of Child Neurology
    Excerpt

    Clinical manifestations were retrospectively assessed in 5 families with tuberous sclerosis complex, including 1 pair of monozygotic twins. Interfamilial variation in tuber count was significantly larger than intrafamilial variation. Severity of epilepsy and cognitive profiles varied both between and within families, particularly between the monozygotic twins, and IQ was inversely related to tuber count. Cutaneous, renal, and cardiac findings did not appear to cluster within families. Although the monozygotic twins displayed similar physical manifestations of tuberous sclerosis complex (renal and cardiac hamartomas), they differed markedly in neurocognitive profiles. Phenotypic variation within these families may be explained largely as a function of the randomness of second-hit events that cause hamartomas in tuberous sclerosis complex or by as-yet-unidentified genetic modifiers. Familial variation in tuberous sclerosis complex phenotype has important implications for genetic counseling.

    Title Magnetic Susceptibility Artifacts on Mri: A Hairy Situation.
    Date March 2004
    Journal Ajr. American Journal of Roentgenology
    Title The Role of Ctla-4 in Regulating Th2 Differentiation.
    Date September 1999
    Journal Journal of Immunology (baltimore, Md. : 1950)
    Excerpt

    To examine the role of CTLA-4 in Th cell differentiation, we used two newly generated CTLA-4-deficient (CTLA-4-/-) mouse strains: DO11. 10 CTLA-4-/- mice carrying a class II restricted transgenic TCR specific for OVA, and mice lacking CTLA-4, B7.1 and B7.2 (CTLA-4-/- B7.1/B7.2-/- ). When purified naive CD4+ DO11.10 T cells from CTLA-4-/- and wild-type mice were primed and restimulated in vitro with peptide Ag, CTLA-4-/- DO11.10 T cells developed into Th2 cells, whereas wild-type DO11.10 T cells developed into Th1 cells. Similarly, when CTLA-4-/- CD4+ T cells from mice lacking CTLA-4, B7. 1, and B7.2 were stimulated in vitro with anti-CD3 Ab and wild-type APC, these CTLA-4-/- CD4+ T cells produced IL-4 even during the primary stimulation, whereas CD4+ cells from B7.1/B7.2-/- mice did not produce IL-4. Upon secondary stimulation, CD4+ T cells from CTLA-4-/- B7.1/B7.2-/- mice secreted high levels of IL-4, whereas CD4+ T cells from B7.1/B7.2-/- mice produced IFN-gamma. In contrast to the effects on CD4+ Th differentiation, the absence of CTLA-4 resulted in only a modest effect on T cell proliferation, and increased proliferation of CTLA-4-/- CD4+ T cells was seen only during secondary stimulation in vitro. Administration of a stimulatory anti-CD28 Ab in vivo induced IL-4 production in CTLA-4-/- B7.1/B7.2-/- but not wild-type mice. These studies demonstrate that CTLA-4 is a critical and potent inhibitor of Th2 differentiation. Thus, the B7-CD28/CTLA-4 pathway plays a critical role in regulating Th2 differentiation in two ways: CD28 promotes Th2 differentiation while CTLA-4 limits Th2 differentiation.

    Title Mri Findings Reveal Three Different Types of Tubers in Patients with Tuberous Sclerosis Complex.
    Date
    Journal Journal of Neurology
    Excerpt

    Cortical tubers are very common in tuberous sclerosis complex (TSC) and widely vary in size, appearance and location. The relationship between tuber features and clinical phenotype is unclear. The aim of the study is to propose a classification of tuber types along a spectrum of severity, using magnetic resonance imaging (MRI) characteristics in 35 patients with TSC and history of epilepsy, and to investigate the relationship between tuber types and genetics, as well as clinical manifestations. Three types of tubers were identified based on the MRI signal intensity of their subcortical white matter component. (1) Tubers Type A are isointense on volumetric T1 images and subtly hyperintense on T2 weighted and fluid-attenuated inversion recovery (FLAIR); (2) Type B are hypointense on volumetric T1 images and homogeneously hyperintense on T2 weighted and FLAIR; (3) Type C are hypointense on volumetric T1 images, hyperintense on T2 weighted, and heterogeneous on FLAIR characterized by a hypointense central region surrounded by a hyperintense rim. Based on the dominant tuber type present, three distinct patient groups were also identified: Patients with Type A tuber dominance have a milder phenotype. Patients with Type C tuber dominance have more MRI abnormalities such as subependymal giant cell tumors, and were more likely to have an autism spectrum disorder, a history of infantile spasms, and a higher frequency of epileptic seizures, compared to patients who have a dominance in Type B tubers, and especially to those with a Type A dominance.


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