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Allergy & Immunology Specialist, Pediatrician
24 years of experience


Education ?

Medical School Score
State University of New York Downstate (1988)

Awards & Distinctions ?

Castle Connolly's Top Doctors™ (2012 - 2013)
Long Island Allergy and Asthma Society
American Board of Allergy and Immunology
American Board of Pediatrics
American Academy of Allergy Asthma and Immunology

Affiliations ?

Dr. Secord is affiliated with 5 hospitals.

Hospital Affiliations



  • Harper University Hospital
    3990 John R St, Detroit, MI 48201
    Top 50%
  • Detroit Receiving Hospital & University Health Center
    4201 Saint Antoine St, Detroit, MI 48201
    Top 50%
  • Sinai-Grace Hospital
    6071 W Outer Dr, Detroit, MI 48235
  • Hutzel Women's Hospital
    3980 John R St, Detroit, MI 48201
  • Children's Hospital of Michigan
    3901 Beaubien St, Detroit, MI 48201
  • Publications & Research

    Dr. Secord has contributed to 7 publications.
    Title A Syndrome of Hypoplastic Sinuses, Hydrocephalus, Bronchiectasis, and Hypogammaglobulinemia with Functional Antibody Deficiency in Twin Girls.
    Date August 2005
    Journal Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

    BACKGROUND: A variety of syndromes are known to be associated with immune deficiency, some as a major part of the syndrome and some as an occasional finding. OBJECTIVES: To report a newly defined syndrome of hydrocephalus, hypoplastic sinuses, cartilaginous webbing of the bronchi, bronchiectasis, and hypogammaglobulinemia with functional antibody deficiency in identical twin girls. METHODS: Spirometry, radiography, computed tomography (CT), bronchoscopy, and laboratory tests were performed for diagnosis. RESULTS: A girl (twin A) was evaluated at the age of 7 years for chronic cough and wheeze that worsened with exercise. Hydrocephalus had been diagnosed a year before evaluation. She was treated for cough variant asthma and was lost to follow-up until the age of 10 years. The cough had worsened progressively, and dyspnea was now apparent. Spirometry was consistent with reversible airway obstruction. A chest radiograph was suggestive of bronchiectasis. A chest CT scan showed bilateral upper lobe bronchiectasis. Hypogammaglobulinemia and functional antibody deficiency were noted. A CT scan of the sinuses revealed aplasia or severe hypoplasia of all the paranasal sinuses. Bronchoscopy revealed a grossly abnormal bronchial structure and atrophic-appearing bronchial mucosa. Twin B also had a history of hydrocephalus. Although she had no respiratory symptoms, chest CT revealed bronchiectasis, and she had obstruction on spirometry. Laboratory analysis revealed hypogammaglobulinemia and functional antibody deficiency. She became symptomatic 2 years after twin A. CONCLUSIONS: This is a newly reported syndrome of hydrocephalus, absent sinuses, abnormalities of the bronchi, and functional antibody deficiency, which initially presented as cough and wheeze.

    Title Panhypopituitarism in a Child with Common Variable Immunodeficiency.
    Date October 2002
    Journal Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

    BACKGROUND: Common variable immunodeficiency (CVID) represents a group of heterogeneous, still undifferentiated, syndromes that are all characterized by defective antibody formation. It is often associated with autoimmune disease. METHODS: An African-American girl was diagnosed with CVID at age 3 years. She was seen during an adrenal crisis precipitated by pneumonia at the age of 8 years and 10 months. The diagnosis of panhypopituitarism was established soon after. RESULTS: Panhypopituitarism in this patient was believed to be the result of the autoimmune process known as lymphocytic hypophysitis. This hypothesis was suggested by the results of magnetic resonance imaging. CONCLUSIONS: Awareness of the possibility of this process in children or adults with CVID may lead to earlier diagnosis of panhypopituitarism. These patients also have failure to thrive, and earlier diagnosis may avoid a life-threatening event.

    Title Atypical Expiratory Flow Volume Curve in an Asthmatic Patient with Vocal Cord Dysfunction.
    Date May 2001
    Journal Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

    BACKGROUND: Vocal cord dysfunction can coexist with or masquerade as asthma. Vocal cord dysfunction, when coexistent with asthma, contributes substantially to the refractory nature of the respiratory problem. OBJECTIVE: To report a case of an asthmatic patient with vocal cord dysfunction and a previously unreported unique expiratory flow volume curve. RESULTS: A 16-year-old female, known to have asthma, developed increased frequency of her asthma exacerbations. Spirometry, during symptoms, showed an extrathoracic airway obstruction with a reproducible unique abrupt drop and rise in the expiratory flow volume loop. Laryngoscopy showed adduction of the vocal cords during inspiration and expiration. CONCLUSIONS: We report a unique expiratory flow volume curve in an asthmatic with vocal cord dysfunction that resolved with panting maneuvers. Speech and psychological counseling helped prevent future attacks.

    Title Components Essential for the Generation of Germinal Centers.
    Date January 1999
    Journal Developmental Immunology
    Title Reconstitution of Germinal Center Formation in Nude Mice with Th1 and Th2 Clones.
    Date January 1997
    Journal Cellular Immunology

    We investigated the ability of hemocyanin (KLH)-specific cloned CD4+ T cells expressing defined cytokine profiles to support germinal center (GC) formation in syngeneic athymic recipients in response to hapten-KLH challenge. Th1 clones producing IL-2 and IFN-gamma did not by themselves increase GC production above background, while Th2 cells producing IL-4 and IL-5 did. However, the combination of Th1 and Th2 cytokines was more effective than Th2 cytokines alone, suggesting a synergistic effect in this aspect of their help for B cells. In contrast to GC formation, antibody production could be induced with Th1 or Th2 clones given separately (Th1 clones inducing IgG2a, and Th2 clones inducing IgG1 and IgE). These results indicate that the T cell requirements for GC production are different from those for isotype switching and Ig secretion. It is postulated that the synergy between Th1 and Th2 cells in the induction of GC formation reflects the synergy between Th1 and Th2 cytokines, such as IFN-gamma and IL-5, in promotion of GC cell proliferation.

    Title Ige Against Hiv Proteins in Clinically Healthy Children with Hiv Disease.
    Date January 1997
    Journal The Journal of Allergy and Clinical Immunology

    Elevated serum Ige was detected in 26% (7 of 30) of children with HIV infection. The majority of children with elevated IgE were of one ethnic group (Puerto Rican) (4 of 7), compared with only 9% (2 of 23) in the normal to low IgE group (p = 0.02). Most of the children with elevated IgE had decreased circulating CD4+ T cells (5 of 7 or 71%); but none had opportunistic infections, and none failed to thrive. Although similar numbers of children with normal to low IgE had decreased circulating CD4+ T cells (19 of 23 or 83%), this group had opportunistic infections (6 of 23 or 26%) and failure to thrive (7 of 30 or 30%). There was no difference in incidence of allergic symptoms between groups. IgE antibody against HIV protein was detected by Western blot technique in the sera of three children with elevated serum IgE. Thus we have identified a group of children with HIV infection and elevated serum IgE of predominantly one ethnic group, who are without opportunistic infections or failure to thrive, some of whom produce HIV-specific IgE. This suggests that IgE may play a protective (perhaps late compensatory) role in HIV disease in genetically predisposed individuals.

    Title The Emu-bcl-2 Transgene Enhances Antigen-induced Germinal Center Formation in Both Balb/c and Sjl Mice but Causes Age-dependent Germinal Center Hyperplasia Only in the Lymphoma-prone Sjl Strain.
    Date September 1995
    Journal The American Journal of Pathology

    Emu-bcl-2 transgenic and littermate control BALB/c and SJL mice were immunized in the front footpads with trinitrophenylated Brucella abortus and the germinal center (GC) response in draining brachial lymph nodes was studied by staining with peanut agglutinin peroxidase and methyl green. Although the GCs induced were not larger in transgenic than in control young mice, there was a significant increase in the percentage of B cell follicles exhibiting GCs 7 to 8 days after primary and secondary antigen injections in the transgenic mice of both strains. In addition, glucocorticosteroid injected on day 7 after the primary injection caused a marked decrease in GCs in littermate controls but had no effect in the bcl-2 transgenic SJL mice. Antibody production to B. abortus was only slightly higher in transgenic than in control mice, but anti-TNP immunoglobulin M and G titers were significantly enhanced in the transgenic mice. The bcl-2 transgenic SJL mice, older than 6 months, showed the spontaneous appearance of large numbers of peanut agglutinin-binding GCs that greatly varied in size and were located without regard for the normal lymph node structure or follicle localization. This GC hyperplasia was seen in a large percent of the older transgenic SJL mice and never in similarly aged normal SJL or BALB/c mice with and without the bcl-2 transgene. Frank lymphomatous transformation of peanut agglutinin-binding germinal center-like areas was seen in lymph nodes and Peyer's patches of some of the older bcl-2 transgenic SJL mice. These results suggest that the tendency of SJL mice to develop GC-derived lymphomas synergizes with the presence of the bcl-2 transgene to cause the development of GC hyperplasia.

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