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Education ?

Medical School Score
Albany Medical College (2004)

Affiliations ?

Dr. Whitman is affiliated with 2 hospitals.

Hospital Affiliations

  • Darnall Army Community Hospital
    36000 Darnall Loop, Killeen, TX 76544
  • Walter Reed Army Medical Center
  • Publications & Research

    Dr. Whitman has contributed to 4 publications.
    Title Evaluation of the Ets-related Gene Mrna in Urine for the Detection of Prostate Cancer.
    Date May 2010
    Journal Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

    Prevalent gene fusions in prostate cancer involve androgen-regulated promoters (primarily TMPRSS2) and ETS transcription factors (predominantly ETS-regulated gene (ERG)], which result in tumor selective overexpression of ERG in two thirds of patients. Because diverse genomic fusion events lead to ERG overexpression in prostate cancer, we reasoned that it may be more practical to capture such alterations using an assay targeting ERG sequences retained in such gene fusions. This study evaluates the potential of an assay quantitating ERG mRNA in post-digital rectal exam (DRE) urine for improving prostate cancer detection.

    Title Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy.
    Date March 2010
    Journal Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology

    A region on chromosome 8q24 was recently identified as a novel prostate cancer risk locus. Inherited variation in this region is associated with prostate cancer risk in the general population (21-58%), and specific alleles show a strong association in African-American men. This study was designed to evaluate associations between 8q24 risk alleles and clinical variables, such as pathologic stage, age at diagnosis, and recurrence, in a case series of African-American men.

    Title Merkel Cell Carcinoma As a Solitary Metastasis to the Testis.
    Date September 2007
    Journal Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
    Title Pca3 Score Before Radical Prostatectomy Predicts Extracapsular Extension and Tumor Volume.
    Journal The Journal of Urology

    PURPOSE: PCA3 is a prostate specific, nonprotein coding RNA that is over expressed in prostate cancer. Recent studies showed the diagnostic potential of a urine based PCA3 for predicting biopsy outcome. We assessed the relationship between urine PCA3 and pathological features in whole mount radical prostatectomy specimens. MATERIALS AND METHODS: Post-digital rectal examination urine specimens were obtained from 72 men with prostate cancer before radical prostatectomy. PCA3 and PSA mRNA were measured. The ratio of PCA3 to PSA mRNA was recorded as a PCA3 score and correlated with data on each prostate specimen. RESULTS: Patients with extracapsular extension had a significantly higher median PCA3 score than patients without extracapsular extension (48.8 vs 18.7, p = 0.02). PCA3 score significantly correlated with total tumor volume (r = 0.38, p <0.01). On multivariate analysis PCA3 score was an independent predictor of extracapsular extension (p = 0.01) and total tumor volume less than 0.5 cc (p = 0.04). At a cutoff PCA3 score of 47 extracapsular extension was predicted with 94% specificity and an 80% positive predictive value. When combined with serum PSA and biopsy Gleason score, the ROC AUC for predicting extracapsular extension was 0.90. CONCLUSIONS: PCA3 detected in the post-digital rectal examination urine of patients with prostate cancer correlated with pathological findings. Therefore, it could provide prognostic information. To our knowledge this is the first report of a molecular urine assay that predicts extracapsular extension.

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