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Education ?

Medical School
St. Joseph University-Faculty of Medicine (1998)

Awards & Distinctions ?

Castle Connolly's Top Doctors™ (2012 - 2013)
Patients' Choice Award (2012, 2014)
Compassionate Doctor Recognition (2014)
On-Time Doctor Award (2014)
American Association for Cancer Research *
American Society of Clinical Oncology *
Consumers Research Council of America *
Michigan State University, School of Human Medicine, (2009 - 2010)
Clinical Assistant Professor of Medicine
Van Andel Research Institute, Grand Rapids,mi (2009 - 2010)
Scientific Investigator, Program of Translational Medicine and Phase I Clinical trials
Creekside Hospice (2011 - Present)
Medical Director
Comprehensive Cancer Centers of Nevada (2010 - Present)
Translational Oncology Program (TOP)
American College of Physicians
American Board of Internal Medicine
American Medical Association
American Society of Clinical Oncology
American Association for Cancer Research

Publications & Research

Dr. Braiteh has contributed to 1 publication.
Title Liposome-encapsulated Curcumin: in Vitro and in Vivo Effects on Proliferation, Apoptosis, Signaling, and Angiogenesis.
Date October 2005
Journal Cancer

BACKGROUND: Because a role for nuclear factor-kappaB (NF-kappaB) has been implicated in the pathogenesis of pancreatic carcinoma, this transcription factor is a potential target for the treatment of this devastating disease. Curcumin (diferuloylmethane) is a phytochemical with potent NF-kappaB-inhibitory activity. It is pharmacologically safe, but its bioavailability is poor after oral administration. METHODS: The authors encapsulated curcumin in a liposomal delivery system that would allow intravenous administration. They studied the in vitro and in vivo effects of this compound on proliferation, apoptosis, signaling, and angiogenesis using human pancreatic carcinoma cells. NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness. These in vitro changes were associated with concentration and time-dependent antiproliferative activity (3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide assay [MTT assay]) and proapoptotic effects (annexin V/propidium iodide staining [fluorescence-activated cell sorting] and polyadenosine-5'-diphosphate-ribose-polymerase cleavage). RESULTS: The activity of liposomal curcumin was equal to or better than that of free curcumin at equimolar concentrations. In vivo, curcumin suppressed pancreatic carcinoma growth in murine xenograft models and inhibited tumor angiogenesis. CONCLUSIONS: Liposomal curcumin down-regulated the NF-kappaB machinery, suppressed growth, and induced apoptosis of human pancreatic cells in vitro. Antitumor and antiangiogenesis effects were observed in vivo. The experiments in the current study provide a biologic rationale for treatment of patients suffering from pancreatic carcinoma with this nontoxic phytochemical encapsulated in liposomes for systemic delivery.

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