Fadi S Braiteh, MD
Medical Oncologist
11 years of experience
Video profile
Accepting new patients
Comprehensive Cancer Centers of Nevada
3730 S Eastern Ave
Las Vegas, NV 89169
(702) 952-3400
Locations and availability (1)

Education ?

Medical School
St. Joseph University-Faculty of Medicine (1998)

Awards & Distinctions ?

Awards  
Castle Connolly's Top Doctors™ (2012)
Patients' Choice Award (2012)
Top Ten Doctors (2012)
Oncology, The Strip, Las Vegas, NV
Appointments
Michigan State University, School of Human Medicine, (2009 - 2010)
Clinical Assistant Professor of Medicine
Van Andel Research Institute, Grand Rapids,mi (2009 - 2010)
Scientific Investigator, Program of Translational Medicine and Phase I Clinical trials
Comprehensive Cancer Centers of Nevada (2010 - Present)
Translational Oncology Program (TOP)
Creekside Hospice (2011 - Present)
Medical Director
Associations
American Society of Clinical Oncology
Member
Academy of Pharmaceutical Physicians and Investigators
American Medical Association
American Association for the Advancement of Science
American Association for Cancer Research
The Histiocyte Society
International Association of Hospice and Palliative Care
American College of Physicians
American Society of Clinical Oncology (cancer.net)
Member

Affiliations ?

Dr. Braiteh is affiliated with 6 hospitals.

Hospital Affilations

Score

Rankings

  • Valley Hospital Medical Center
    620 Shadow Ln, Las Vegas, NV 89106
    • Currently 4 of 4 crosses
    Top 25%
  • St Rose Dominican Hospital
    102 E Lake Mead Pkwy, Henderson, NV 89015
    • Currently 2 of 4 crosses
  • Sunrise Hospital & Medical Center *
    Medical Oncology
    3186 S Maryland Pkwy, Las Vegas, NV 89109
    • Currently 1 of 4 crosses
  • St. Rose - Rose de Lima & Siena Campus
  • ST ROSE DOMINICAN HOSP - San Martin
    8280 W Warm Springs Rd, Las Vegas, NV 89113
  • Desert Springs Hospital Medical Center - Las Vegas *
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Braiteh has contributed to 1 publication.
    Title Liposome-encapsulated Curcumin: in Vitro and in Vivo Effects on Proliferation, Apoptosis, Signaling, and Angiogenesis.
    Date October 2005
    Journal Cancer
    Excerpt

    BACKGROUND: Because a role for nuclear factor-kappaB (NF-kappaB) has been implicated in the pathogenesis of pancreatic carcinoma, this transcription factor is a potential target for the treatment of this devastating disease. Curcumin (diferuloylmethane) is a phytochemical with potent NF-kappaB-inhibitory activity. It is pharmacologically safe, but its bioavailability is poor after oral administration. METHODS: The authors encapsulated curcumin in a liposomal delivery system that would allow intravenous administration. They studied the in vitro and in vivo effects of this compound on proliferation, apoptosis, signaling, and angiogenesis using human pancreatic carcinoma cells. NF-kappaB was constitutively active in all human pancreatic carcinoma cell lines evaluated and liposomal curcumin consistently suppressed NF-kappaB binding (electrophoretic mobility gel shift assay) and decreased the expression of NF-kappaB-regulated gene products, including cyclooxygenase-2 (immunoblots) and interleukin-8 (enzyme-linked immunoassay), both of which have been implicated in tumor growth/invasiveness. These in vitro changes were associated with concentration and time-dependent antiproliferative activity (3-[4,5-dimethylthiazol-2-yl]2,5-diphenyltetrazolium bromide assay [MTT assay]) and proapoptotic effects (annexin V/propidium iodide staining [fluorescence-activated cell sorting] and polyadenosine-5'-diphosphate-ribose-polymerase cleavage). RESULTS: The activity of liposomal curcumin was equal to or better than that of free curcumin at equimolar concentrations. In vivo, curcumin suppressed pancreatic carcinoma growth in murine xenograft models and inhibited tumor angiogenesis. CONCLUSIONS: Liposomal curcumin down-regulated the NF-kappaB machinery, suppressed growth, and induced apoptosis of human pancreatic cells in vitro. Antitumor and antiangiogenesis effects were observed in vivo. The experiments in the current study provide a biologic rationale for treatment of patients suffering from pancreatic carcinoma with this nontoxic phytochemical encapsulated in liposomes for systemic delivery.

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