26 years of experience
Video profile
Accepting new patients
Lawrenceville Urology
2 Princess Rd
Ste J
Lawrence Township, NJ 08648
Locations and availability (2)

Education ?

Medical School Score
Rosalind Franklin University (1984)
  • Currently 2 of 4 apples

Awards & Distinctions ?

American Board of Urology
American Urological Association

Affiliations ?

Dr. Karlin is affiliated with 10 hospitals.

Hospital Affilations



  • Rwj University Hospital - Hamilton
    1 Hamilton Health Pl, Trenton, NJ 08690
    • Currently 4 of 4 crosses
    Top 25%
  • Robert Wood Johnson Univ Hosp
    1 Robert Wood Johnson Pl, New Brunswick, NJ 08901
    • Currently 2 of 4 crosses
  • St Francis Medical Center
    601 Hamilton Ave, Trenton, NJ 08629
    • Currently 2 of 4 crosses
  • Capital Health System - Mercer Campus
    446 Bellevue Ave, Trenton, NJ 08618
    • Currently 2 of 4 crosses
  • Capital Health System - Fuld Campus
    750 Brunswick Ave, Trenton, NJ 08638
    • Currently 2 of 4 crosses
  • University Medical Center At Princeton
    253 Witherspoon St, Princeton, NJ 08540
    • Currently 1 of 4 crosses
  • CHS, Inc Mercer Campus
  • Princeton House Behavorial Healthcare
    905 Herrontown Rd, Princeton, NJ 08540
  • Mercer Medical Center
  • Rwjuh Hamilton
  • Publications & Research

    Dr. Karlin has contributed to 9 publications.
    Title Open-label Trial Evaluating the Safety and Efficacy of Zoledronic Acid in Preventing Bone Loss in Patients with Hormone-sensitive Prostate Cancer and Bone Metastases.
    Date December 2005
    Journal Urology

    OBJECTIVES: To evaluate the efficacy and safety of zoledronic acid in preventing bone loss in patients with hormone-sensitive prostate cancer and bone metastases who were receiving androgen deprivation therapy. METHODS: Patients received zoledronic acid 4 mg as a 15-minute infusion every 3 weeks for 1 year. Bone mineral density of the lumbar spine (L2 to L4) and total hip was measured by dual-energy x-ray absorptiometry at baseline and 12 months. Biochemical markers of bone turnover (N-telopeptide and bone alkaline phosphatase) and serum creatinine levels were evaluated at baseline and during the study. Skeletal-related events were assessed at each study visit. RESULTS: Of the 221 enrolled patients, 202 and 221 patients were included in the efficacy and safety analyses, respectively. The mean increase in bone mineral density of the lumbar spine and total hip was 7.7% (P <0.001) and 3.6% (P <0.001), respectively. Decreases in N-telopeptide and bone alkaline phosphatase levels were significant and sustained. The median time to the first skeletal-related event was not reached; 11.9% of patients had a skeletal-related event. Arthralgia (20.4%), nausea (14%), fatigue (14%), and back pain (12.2%) were the most common adverse events. Adverse events due to renal function deterioration were infrequent. The mean maximal change in serum creatinine level from baseline was 0.3 mg/dL. CONCLUSIONS: Zoledronic acid administration for 1 year to patients with hormone-sensitive prostate cancer and bone metastases who were receiving androgen deprivation therapy was safe and prevented bone loss, as demonstrated by significant increases in bone mineral density and sustained suppression of biochemical markers of bone turnover.

    Title Safety and Efficacy of Vardenafil for the Treatment of Men with Erectile Dysfunction After Radical Retropubic Prostatectomy.
    Date November 2003
    Journal The Journal of Urology

    PURPOSE: More than one-third of men may experience erectile dysfunction (ED) after nerve sparing radical retropubic prostatectomy. The efficacy and safety of vardenafil, a potent, selective, phosphodiesterase 5 inhibitor, was assessed for the treatment of ED after radical prostatectomy. MATERIALS AND METHODS: In this double-blind study 440 men with ED after nerve sparing radical prostatectomy were randomized to take placebo, or 10 or 20 mg vardenafil. Efficacy was measured after 12 weeks using the erectile function domain of the International Index of Erectile Function, diary questions measuring vaginal penetration and intercourse success rates, and a global assessment question (GAQ) on erection. RESULTS: Of the intent to treat population 70% had severe ED (erectile function less than 11) at baseline. After 12 weeks both vardenafil doses were significantly superior to placebo (p <0.0001) for all efficacy variables. Improved erections (based on GAQ) were reported by 65.2% and 59.4% of patients on 20 and 10 mg vardenafil, respectively, and by only 12.5% of patients on placebo (p <0.0001). Among men with bilateral neurovascular bundle sparing, positive GAQ responses were reported by 71.1% and 59.7% of patients on 20 and 10 mg vardenafil, respectively, versus 11.5% of those on placebo (p <0.0001). The average intercourse success rate per patient receiving 20 mg vardenafil was 74% in men with mild to moderate ED and 28% in men with severe ED, compared to 49% and 4% for placebo, respectively. Few adverse events were observed. They were generally mild to moderate headache, flushing and rhinitis. CONCLUSIONS: In men with severe ED after nerve sparing radical retropubic prostatectomy, vardenafil significantly improved key indices of erectile function.

    Title Absence of Persisting Parenchymal Damage After Extracorporeal Shock Wave Lithotripsy As Judged by Excretion of Renal Tubular Enzymes.
    Date July 1990
    Journal The Journal of Urology

    Four renal tubular enzymes, N-acetyl-beta-glucosaminidase, beta-galactosidase, angiotensin-converting enzyme and gamma-glutamyltransferase, were measured in the urine before, and 24 hours and 1 week after extracorporeal shock wave lithotripsy in 20 consecutive patients. Extracorporeal shock wave lithotripsy was performed on the Sonolith 2000 device with the patient under intravenous narcotic sedation with fentanyl. Enzymatic activity per gram of urinary creatinine was consistently but not significantly higher before extracorporeal shock wave lithotripsy than in control subjects. All 4 enzymes were elevated 24 hours after extracorporeal shock wave lithotripsy, with the increases in beta-galactosidase and angiotensin-converting enzyme being statistically significant. However, by 7 days after the procedure the enzymes had decreased to pre-procedure concentrations or below. These data suggest that any renal tubular damage induced by extracorporeal shock wave lithotripsy is of limited magnitude and brief duration.

    Title Endourologic Management of Lower Urinary Tract Dysfunction.
    Date March 1990
    Journal Clinics in Geriatric Medicine

    Management of urinary dysfunction in the elderly needs to be achieved with the least amount of patient morbidity. Endourologic techniques have been successful in treating lower urinary tract pathology in the elderly.

    Title Greenberg Surgical Support System for the Endourologist.
    Date March 1990
    Journal The Urologic Clinics of North America

    As the field of endourology diversifies, the importance of ergonomics grows. The technology developed to assist the endourologist may accomplish the surgical goals effectively, but it often does not consider instrument control, planning of space, and the physical comfort of the operator. The Greenberg retractor creates a surgical environment that improves the urologist's efficiency and technical proficiency. Complex staghorn cases can be performed with reduced risk of inadvertent damage to renal tissue, no shifts of the nephroscope, and a more productive experience for the assistant.

    Title Approaches to the Superior Calix: Renal Displacement Technique and Review of Options.
    Date October 1989
    Journal The Journal of Urology

    A new percutaneous approach to the superior calix has been implemented with reduced morbidity. To avoid intercostal or retrograde punctures or triangulation methods an Amplatz sheath passed through a central or lower pole calix can be pushed caudally while descent of the kidney is viewed fluoroscopically. An 18-gauge TLA needle passed through the initial skin puncture then is used to form a Y with the original tract. This method has been successful in 21 of 25 cases without complications. The only failures occurred in patients with immobile kidneys secondary to a previous operation.

    Title Endopyelotomy Versus Open Pyeloplasty: Comparison in 88 Patients.
    Date September 1988
    Journal The Journal of Urology

    We compared the results of the first 56 consecutive percutaneous corrections of ureteropelvic junction obstruction (endopyelotomy) at our institution with the most recent 32 consecutive cases of open pyeloplasty. The percutaneous procedure required less time (average 89.4 minutes versus 106.4 minutes for an open operation) and entailed less postoperative pain (60 per cent of the patients required an average of 4.7 unit doses of narcotics, whereas 88 per cent of the pyeloplasty patients required an average of 10.3 unit doses). The average hospital stay was less after endopyelotomy (average 6.2 versus 10.0 days) and return to normal activity occurred more quickly (average 19.8 versus 41.5 days). Endopyelotomy was successful in 87.5 per cent of the patients, with all failures being apparent within 6 weeks and they were easily correctable by traditional methods. Reported success rates of pyeloplasty ranged from 95 to 98 per cent.

    Title Endopyelotomy.
    Date September 1988
    Journal The Urologic Clinics of North America

    Endopyelotomy has developed from the advances of endourology and has become an accepted means to correct ureteropelvic junction obstruction. Endopyelotomy can be performed with less morbidity than pyeloplasty, with less operative and anesthetic time, less analgesic requirements, and a shorter recovery period. With success rates of 88.8 per cent for primary obstruction and 89 per cent for secondary obstruction, provided patients are selected appropriately, endopyelotomy has become a valuable procedure for the correction of ureteropelvic junction obstruction. The longest follow-up is 4 years, and therefore long-term success rates cannot be quoted. Time will reveal the ultimate place for endopyelotomy.

    Title Treatment of Ureteropelvic Strictures with Percutaneous Pyelotomy: Experience in 62 Patients.
    Date September 1988
    Journal Ajr. American Journal of Roentgenology

    Percutaneous pyelotomy (endopyelotomy) is an endoscopic technique for the management of ureteropelvic junction obstruction. In a series of 62 consecutive patients, the success rate (measured by symptom-free status and improved uroradiographic findings) was 85%, including both primary and secondary obstructions. All failures were apparent within 3 months of the procedure and required open surgery. There were two major complications during the procedure. Our experience indicates that percutaneous pyelotomy is an effective alternative to traditional open pyeloplasty and has a similar success rate, lower morbidity, and a shorter recovery time.

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