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Education ?

Medical School
Dhaka Medical College (1984)
Foreign school
University of Michigan Hospital (2001) *
Allergy & Immunology
* This information was reported to Vitals by the doctor or doctor's office.

Awards & Distinctions ?

Patients' Choice Award (2009)
Long Island Allergy and Asthma Society
American Academy of Allergy Asthma and Immunology
American Board of Internal Medicine
American Board of Allergy and Immunology

Affiliations ?

Dr. Shome is affiliated with 8 hospitals.

Hospital Affiliations



  • Covenant Medical Center
    3615 19th St, Lubbock, TX 79410
    Top 25%
  • Covenant Children's Hospital
    3610 21st St, Lubbock, TX 79410
  • University Medical Center - Lubbock
    602 Indiana Ave, Lubbock, TX 79415
  • Covenant Hospital Levelland
    1900 College Ave, Levelland, TX 79336
  • Covenant Hospital Plainview
    2601 Dimmitt Rd, Plainview, TX 79072
  • Covenant Health System
  • University Medical Center
  • University Medical Center, Tx Tech Univ
  • Publications & Research

    Dr. Shome has contributed to 11 publications.
    Title Treatment of Kounis Syndrome.
    Date December 2010
    Journal International Journal of Cardiology

    Kounis syndrome is potentially a life-threatening medical emergency with both a severe allergic reaction and acute coronary syndrome. Most of the information about this syndrome has come from the case reports. The management of these patients may be challenging for clinicians, and unfortunately guidelines have not been established yet. In this article, we review the current guidelines of acute coronary syndromes and anaphylaxis along with the published cases with Kounis syndrome secondary to beta-lactam antibiotics. We have summarized our recommendations for the work-up and treatment of Kounis syndrome from available data. Obviously, larger prospective studies are needed to establish definitive treatment guidelines for these patients.

    Title Acute Stress Affects the Physiology and Behavior of Allergic Mice.
    Date October 2009
    Journal Physiology & Behavior

    Physical and psychological stressors have been implicated in acute asthma exacerbation. The objective of the current study was to determine the effects of forced swimming stress (FST) on allergic pulmonary inflammation in BALB/c mice. Eighty female mice were allocated to one of four treatments arranged in a 2 x 2 factorial consisting of two levels of allergy and two levels of stress. The effects of stress and allergy were assessed by examination of cytokines and leukocyte differentials in the bronchoalveolar lavage fluid, corticosterone and immunoglobulin (Ig) E in the plasma, leukocyte differentials in the peripheral blood, natural killer cytotoxicity, and histopathology of the lungs. Behavior was recorded during the FST. Stress and allergy increased plasma corticosterone in mice. Allergy increased IgE concentrations and pulmonary inflammation. Interleukin-4 was greater among allergic stressed and non-stressed mice and stressed, non-allergic mice compared with non-stressed, non-allergic mice. Interleukin-5 (IL-5) and 6 (IL-6) were greater among allergic stressed and non-stressed mice compared with non-allergic mice. Interleukin-5 and 6 were reduced among stressed-allergic mice compared with non-stressed, allergic mice. Stress and allergy shifted mice towards a T-helper 2 response as shown by increased interleukin-4. Stress reduced IL-5 and IL-6 in allergic mice but not non-allergic mice. Pulmonary inflammation was not reduced among allergic stressed mice in spite of elevated glucocorticoids. Mice induced to be allergic responded to FST differently than non-allergic mice. Our findings suggest that stress induces a differential response among allergic and non-allergic mice.

    Title Cytokine Expression in Peripheral Blood Lymphocytes Before and After Aspirin Desensitization in Aspirin-exacerbated Respiratory Disease.
    Date March 2008
    Journal Allergy and Asthma Proceedings : the Official Journal of Regional and State Allergy Societies

    Aspirin intolerance is the hallmark of aspirin-exacerbated respiratory disease (AERD). Overproduction of cysteinyl-leukotrienes (Cys-LTs) has been implicated as major mediators of AERD; however, the LT receptor antagonist montelukast is only partially effective in inhibiting aspirin responses. Several studies have documented the importance of cytokine production by T lymphocytes in asthma. Peripheral blood lymphocyte (PBL) cytokine expression and its relation to aspirin desensitization in aspirin-sensitive patients with asthma have not been studied. This study was performed to examine PBL cytokine expression in aspirin-sensitive patients who have asthma before and after aspirin desensitization. A 42-year-old white woman with a history of severe asthma, nasal polyps, aspirin sensitivity, and chronic sinusitis was treated with aspirin desensitization. Blood was taken before and after aspirin desensitization, and PBL cytokine expression was studied by flow cytometry. Aspirin desensitization differentially affects interferon (IFN) gamma expression. This effect results in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes. Aspirin desensitization in an aspirin-sensitive patient with asthma resulted in an increase in IFN-gamma expression by CD4(+) lymphocytes and a decrease in IFN-gamma expression by CD8(+) lymphocytes, the significance of which needs additional investigation.

    Title Exhaled Nitric Oxide in Asthma: Variability, Relation to Asthma Severity, and Peripheral Blood Lymphocyte Cytokine Expression.
    Date June 2006
    Journal The Journal of Asthma : Official Journal of the Association for the Care of Asthma

    Exhaled nitric oxide has been used as a means of indirectly measuring the underlying inflammation in asthma. The objectives of the study were to measure exhaled nitric oxide levels in asthma patients and healthy volunteers, to study peripheral blood lymphocyte cytokine expression, and to study the relationship between exhaled nitric oxide and intracellular cytokine expression. Exhaled nitric oxide was elevated in patients with moderate to severe asthma and with treatment decreased in the first week reaching to a near normal level by 4 weeks. Elevated exhaled nitric oxide was associated with decreased IL-4 and IL-13 cytokine expression by CD8 lymphocytes.

    Title Flushing and Syncopal Episode in a 47-year-old Female.
    Date April 2001
    Journal Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
    Title Appendiceal Endometriosis Presenting As Massive Lower Intestinal Hemorrhage.
    Date October 1995
    Journal The American Journal of Gastroenterology

    Appendiceal endometriosis is a very uncommon clinical entity. We describe a 33-yr-old white female who presented with painless profuse rectal bleeding. Emergency colonoscopy revealed bleeding from the appendiceal opening. An emergency appendectomy was performed which controlled her bleeding. The histopathological examination demonstrated appendiceal endometriosis. Painless bleeding from appendiceal endometriosis is extremely rare; however, it should be considered when evaluating young women of reproductive age who present with rectal bleeding.

    Title Clinical Features of Patients with Mild Systemic Lupus Erythematosus.
    Date February 1992
    Journal Scandinavian Journal of Rheumatology

    Clinical features of 16 patients with mild systemic lupus erythematosus (SLE) were compared with those of 21 control patients with moderate or severe disease. Age at the time of diagnosis of SLE was higher in mild disease group. The incidence of the coexistence of Sjögren's syndrome (SS) at the time of diagnosis of SLE was higher in patients who later developed mild disease. Anti-Sm antibody and decreased levels of C3, C4, and CH50 occurred less frequently in patients with mild disease. SLE patients with the coexistence of SS at the time of diagnosis of SLE may represent a subset with a benign prognosis.

    Title Decreased Release of Leukotriene B4 from Monocytes and Polymorphonuclear Leukocytes in Patients with Systemic Lupus Erythematosus.
    Date June 1991
    Journal Arerugī = [allergy]

    The leukotriene B4 (LTB4) releasing capacities of monocytes and polymorphonuclear leukocytes (PMN) were studied using a specific radioimmunoassay in 28 patients with systemic lupus erythematosus (SLE) and 9 normal controls. LTB4 release from both monocytes (7.3 +/- 3.3 ng) and PMN (6.6 +/- 3.4 ng) in SLE patients was decreased compared with that (15.2 +/- 4.3 ng for monocytes, 20.7 +/- 4.5 ng for PMN) in normal controls. There were no differences in the releasing capacities of monocytes and PMN between patients with active and inactive disease. LTB4 suppressed lymphocyte blastogenesis by PHA-P and induced suppressor cells. The significance of the decreased release of LTB4 from monocytes and PMN in SLE patients was discussed.

    Title Ischemic Heart Disease in Systemic Lupus Erythematosus. A Retrospective Study of 65 Patients Treated with Prednisolone.
    Date January 1990
    Journal Japanese Journal of Medicine

    We studied the frequency of ST-T changes and ischemic heart disease (IHD) in prednisolone (PSL)-treated systemic lupus erythematosus (SLE) patients and compared them with the age-matched control of rheumatoid arthritis patients not receiving PSL. Twenty-five (38%) of the 65 SLE patients revealed ST-T changes as ST elevation (4%), ST depression (36%) and T wave flattening or inversion (60%). Among the control patients 4 (10%) had T wave flattening or inversion. The frequencies of ST-T changes in patients receiving total PSL dose of up to 5g and greater than 5g were 23% and 48%, respectively. Four patients developed IHD at an unusually young age during remission of SLE while receiving low dose of PSL and 2 of them later died of myocardial infarction (MI). The latter 2 patients had received PSL pulse therapy prior to MI. Regular ECG check up for SLE patients while they are on low dose PSL or pulse therapy may help reveal early ECG abnormalities and thus detect and treat one of the major risks of long-term effects of corticosteroid therapy.

    Title Chloramphenicol-resistant Salmonella Typhi in a Patient Presented with Watery Diarrhoea.
    Date July 1989
    Journal Journal of Diarrhoeal Diseases Research
    Title Persistent Diarrhoea: a Preliminary Report on Clinical Features and Dietary Therapy in Bangladeshi Children.
    Date July 1989
    Journal Journal of Tropical Pediatrics

    Twenty-six infants and children aged 2-24 months suffering from diarrhoea for more than 2 weeks were studied in the ICDDRB's Dhaka Treatment Centre. They presented with watery diarrhoea and the majority had moderate dehydration. A stool pathogen was isolated in only one infant. Systemic infections co-existed in half of the subjects. Subjects between 4 and 12 months of age were moderately malnourished. The remainder were severely malnourished. A range of therapeutic diets were given according to the clinical progress of the subjects. Three children improved with a milk-based diet, two with a soya-based proprietary diet, eight with a rice-based diet, 12 with comminuted chicken, and one with yoghurt. Response to various diets appeared to be age related. Body weight of 21 subjects deteriorated before cessation of diarrhoea. Case fatality rate was 11 per cent due to septicaemia and bronchopneumonia. Most persistent diarrhoea patients without severe concurrent systemic infections were effectively treated using various locally prepared diets.

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