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Internist, Endocrinologist (diabetes, hormones), Pediatrician
15 years of experience
Video profile
Accepting new patients

Credentials

Education ?

Medical School Score
Loyola University Chicago (1996)
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Awards & Distinctions ?

Associations
American Board of Internal Medicine
American Board of Pediatrics
American Association of Clinical Endocrinologists

Affiliations ?

Dr. Shea is affiliated with 11 hospitals.

Hospital Affiliations

Score

Rankings

  • Harris Methodist H E B
    1600 Hospital Pkwy, Bedford, TX 76022
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    Top 25%
  • Children's Medical Center of Dallas
    1935 Motor St, Dallas, TX 75235
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    Top 25%
  • Texas Health Presbyterian Hospital Plano
    6200 W Parker Rd, Plano, TX 75093
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    Top 25%
  • Texas Health Harris Methodist Hospital Southwest Fort Worth
    6100 Harris Pkwy, Fort Worth, TX 76132
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    Top 25%
  • Texas Health Presbyterian Hospital Of Dallas
    8200 Walnut Hill Ln, Dallas, TX 75231
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    Top 50%
  • Texas Health Harris Methodist Hospital Azle
    108 Denver Trl, Azle, TX 76020
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    Top 50%
  • Medical Center Of Plano
    3901 W 15th St, Plano, TX 75075
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  • Harris Methodist - Springwood
    1608 Hospital Pkwy, Bedford, TX 76022
  • Texas Health Plano
  • Texas Health Dallas
  • Harris Continued Care Hospital
    1301 Pennsylvania Ave, Fort Worth, TX 76104
  • Publications & Research

    Dr. Shea has contributed to 1 publication.
    Title Analysis of Hsd3b7 Knockout Mice Reveals That a 3alpha-hydroxyl Stereochemistry is Required for Bile Acid Function.
    Date September 2007
    Journal Proceedings of the National Academy of Sciences of the United States of America
    Excerpt

    Primary bile acids are synthesized from cholesterol in the liver and thereafter are secreted into the bile and small intestine. Gut flora modify primary bile acids to produce secondary bile acids leading to a chemically diverse bile acid pool that is circulated between the small intestine and liver. A majority of primary and secondary bile acids in higher vertebrates have a 3alpha-hydroxyl group. Here, we characterize a line of knockout mice that cannot epimerize the 3beta-hydroxyl group of cholesterol and as a consequence synthesize a bile acid pool in which 3beta-hydroxylated bile acids predominate. This alteration causes death in 90% of newborn mice and decreases the absorption of dietary cholesterol in surviving adults. Negative feedback regulation of bile acid synthesis mediated by the farnesoid X receptor (FXR) is disrupted in the mutant mice. We conclude that the correct stereochemistry of a single hydroxyl group at carbon 3 in bile acids is required to maintain their physiologic and regulatory functions in mammals.

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