Surgeons, Pediatric Surgeon
5 years of experience

34th Civic Center Blvd
Philadelphia, PA 19104
215-590-1000
Locations and availability (1)

Education ?

Medical School
Tulane University (2005)

Awards & Distinctions ?

Associations
American College of Surgeons

Publications & Research

Dr. Roybal has contributed to 3 publications.
Title Predicting the Severity of Congenital High Airway Obstruction Syndrome.
Date December 2010
Journal Journal of Pediatric Surgery
Excerpt

Congenital high airway obstruction syndrome (CHAOS) is caused by complete or near-complete obstruction of the fetal airway. Obstruction sets in motion a sequence of events that can ultimately lead to fetal demise. However, on rare occasions in utero airway decompression occurs, reversing syndromic findings and improving the prognosis. In our relatively large series of CHAOS patients, we have observed a spectrum of clinical severity. The aim of this study was to identify the prenatal characteristics of CHAOS predictive of a milder postnatal course.

Title Stem Cell and Genetic Therapies for the Fetus.
Date April 2010
Journal Seminars in Fetal & Neonatal Medicine
Excerpt

Advances in prenatal diagnosis have led to the prenatal management of a variety of congenital diseases. Although prenatal stem cell and gene therapy await clinical application, they offer tremendous potential for the treatment of many genetic disorders. Normal developmental events in the fetus offer unique biologic advantages for the engraftment of hematopoietic stem cells and efficient gene transfer that are not present after birth. Although barriers to hematopoietic stem cell engraftment exist, progress has been made and preclinical studies are now underway for strategies based on prenatal tolerance induction to facilitate postnatal cellular transplantation. Similarly, in-utero gene therapy shows experimental promise for a host of diseases and proof-in-principle has been demonstrated in murine models, but ethical and safety issues still need to be addressed. Here we review the current status and future potential of prenatal cellular and genetic therapy.

Title Prenatal Stem Cell Transplantation and Gene Therapy.
Date October 2009
Journal Clinics in Perinatology
Excerpt

At the present time, the most likely and eminent application of stem cell therapy to the fetus is in utero hematopoietic stem cell transplantation (IUHCT), and this stem cell type will be discussed as a paradigm for all prenatal stem cell therapy. The authors feel that the most likely initial application of IUHCT will use adult HSC derived from bone marrow (BM) or peripheral blood (PB), and will focus this article on this specific approach. The article also reviews the experimental data that support the capacity of IUHCT to induce donor-specific tolerance.


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