Urologists
16 years of experience
Video profile
Accepting new patients
8625 Collier Blvd
Suite 250
Naples, FL 34114
Locations and availability (5)

Education ?

Medical School Score
George Washington University (1994)
  • Currently 2 of 4 apples

Awards & Distinctions ?

Awards  
Top Docs 2012
Top Docs 2011
Castle Connolly's Top Doctors™ (2012 - 2013)
Associations
American Urological Association
American Board of Urology

Affiliations ?

Dr. Chon is affiliated with 8 hospitals.

Hospital Affilations

Score

Rankings

  • Thomas Jefferson University Hospital
    Urology
    111 S 11th St, Philadelphia, PA 19107
    • Currently 4 of 4 crosses
    Top 25%
  • Methodist Hospital
    Urology
    2301 S Broad St, Philadelphia, PA 19148
    • Currently 3 of 4 crosses
    Top 50%
  • Holy Redeemer Health System
    1648 Huntingdon Pike, Jenkintown, PA 19046
    • Currently 3 of 4 crosses
    Top 50%
  • Abington Memorial Hospital *
    1200 Old York Rd, Abington, PA 19001
    • Currently 2 of 4 crosses
  • Warminster Hospital
    225 Newtown Rd, Warminster, PA 18974
    • Currently 2 of 4 crosses
  • Doylestown Hospital
    Urology
    595 W State St, Doylestown, PA 18901
    • Currently 1 of 4 crosses
  • Thomas Jefferson University Hospitals, Inc-Methodist Hospital Div
  • Holy Redeemer Hospital and Medical Center
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Chon has contributed to 6 publications.
    Title Conformational Flexibility in Mammalian 15s-lipoxygenase: Reinterpretation of the Crystallographic Data.
    Date April 2008
    Journal Proteins
    Excerpt

    Lipoxygenases (LOXs) are a family of nonheme iron dioxygenases that catalyze the regioselective and stereospecific hydroperoxidation of polyunsaturated fatty acids, and are involved in a variety of inflammatory diseases and cancers. The crystal structure of rabbit 15S-LOX1 that was reported by Gillmor et al. in 1997 has played key roles for understanding the properties of mammalian LOXs. In this structure, three segments, including 12 residues in the superficial alpha2 helix, are absent and have usually been described as "disordered." By reinterpreting the original crystallographic data we were able to elucidate two different conformations of the molecule, both having well ordered alpha2 helices. Surprisingly, one molecule contained an inhibitor and the other did not, thereby adopting a closed and an open form, respectively. They differed in the conformation of the segments that were absent in the original structure, which is highlighted by a 12 A movement of alpha2. Consequently, they showed a difference in the size and shape of the substrate-binding cavity. The new model should provide new insight into the catalytic mechanism involving induced conformational change of the binding pocket. It may also be helpful for the structure-based design of LOX inhibitors.

    Title Urethrolysis with Martius Labial Fat Pad Graft for Iatrogenic Bladder Outlet Obstruction.
    Date June 2003
    Journal Urology
    Excerpt

    This article evaluates treatment outcomes of urethrolysis with the Martius labial fat pad graft for patients with outlet obstruction after incontinence surgery. A total of 23 women were diagnosed with iatrogenic bladder outlet obstruction by urinary retention, urodynamic criteria, physical examination findings, and/or temporal relation of voiding dysfunction to anti-incontinence surgery. The urodynamic definition of female outlet obstruction was a maximum flow rate <12 mL/sec and a detrusor pressure at maximum flow >20 cm of water. Surgical treatment consisted of urethrolysis with complete circumferential urethral mobilization. A Martius labial fat pad graft was used to circumferentially wrap the urethra. No concurrent resuspension procedures were performed. Procedure efficacy was determined by retrospective review and phone interview. Mean patient age was 55 years (range, 37 to 85 years). Mean postoperative follow-up time was 15 months (maximum, 44 months). All patients related voiding dysfunction symptoms to their anti-incontinence surgery. In all, 17 of 23 (74%) patients had preoperative urinary retention requiring catheterization, and 63% of patients met urodynamic criteria for obstruction. After urethrolysis with a Martius labial fat pad graft, 20 of 23 (87%) patients had complete resolution of their obstruction; 3 patients required persistent catheterization. Postoperative stress incontinence was reported by 6 of 23 (13%) patients. Urodynamically documented detrusor instability occurred in 6 of 23 (26%) patients with de novo detrusor instability occurring in 3 of 15 (20%) patients.

    Title Vesicouterine Fistula After Uterine Artery Embolization: a Case Report.
    Date January 2003
    Journal American Journal of Obstetrics and Gynecology
    Excerpt

    Complications of uterine artery embolization (UAE) for treatment of leiomyoma uteri include contrast reactions, hematoma, postembolization syndrome, infection, pulmonary embolus, premature ovarian failure, and uterine necrosis. We present a case of vesicouterine fistula and extrusion of a degenerating leiomyoma into the bladder after UAE, necessitating hysterectomy and partial cystectomy for repair.

    Title Combined Effect of Terazosin and Finasteride on Apoptosis, Cell Proliferation, and Transforming Growth Factor-beta Expression in Benign Prostatic Hyperplasia.
    Date March 2001
    Journal The Prostate
    Excerpt

    BACKGROUND: Medical treatment of benign prostatic hyperplasia (BPH) targets relief of symptoms by causing either relaxation of the prostatic smooth muscle with alpha1 adrenergic blockade, or shrinkage of the gland with 5alpha-reductase inhibitors. We recently demonstrated that alpha1-blockers, such as terazosin, induce apoptosis in prostatic cells. In this study, we examined the combined effect of finasteride and terazosin on the rate of apoptosis and cellular proliferation to investigate their potential synergy at the cellular level. METHODS: Prostate specimens were obtained from men who were treated with either finasteride (n = 24), terazosin (n = 42), or combination therapy (n = 10) for varying time periods (1 week to 36 months) for the relief of the symptoms of BPH. The proliferative and apoptotic indices of both stromal and epithelial prostatic cell populations were determined. Antibodies against TGF-beta1 and TbetaRII were used to examine the immunoreactivity of TGF-beta1 and TbetaRII, respectively, in all prostate tissue sections. RESULTS: The apoptotic index in both prostate cell populations was significantly higher following the combination treatment compared to terazosin or finasteride alone. There were no significant changes in the rate of cellular proliferation with any treatment. Furthermore, there was a significant increase in TGF-beta1 expression in the prostates of patients treated with terazosin or combination therapy, while there was no change in TbetaRII expression. CONCLUSIONS: These results support the concept that induction of prostate apoptosis is a potential molecular mechanism underlying the combination effect of alpha1 blockade with 5alpha-reductase inhibitors in the effective treatment of BPH. The upregulation of TGF-beta1 implies a role for this ligand as an effector of apoptosis induction in response to alpha1-blockade or finasteride therapy of BPH patients.

    Title The Cost Value of Medical Versus Surgical Hormonal Therapy for Metastatic Prostate Cancer.
    Date September 2000
    Journal The Journal of Urology
    Excerpt

    The cost of luteinizing hormone releasing hormone analogue and antiandrogen for prostate cancer is being scrutinized by the Health Care Finance Administration and other insurers. We compared the discounted present value cost of medical hormonal therapy to that of orchiectomy as well as the value created by these treatments from the insurer and patient perspectives.

    Title Alpha 1-adrenoceptor Antagonists Terazosin and Doxazosin Induce Prostate Apoptosis Without Affecting Cell Proliferation in Patients with Benign Prostatic Hyperplasia.
    Date June 1999
    Journal The Journal of Urology
    Excerpt

    Recent evidence indicated that an alpha 1 blocker, doxazosin, induces prostate apoptosis in patients with benign prostatic hyperplasia (BPH). In this study, to determine whether this apoptotic response was mediated by alpha 1 adrenoceptor-dependent mechanism or was specific to doxazosin, we examined the effect of another alpha 1 blocker, terazosin, in addition to doxazosin, on the dynamics of prostate cell growth.


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