Browse Health
Pathologist
40 years of experience
Accepting new patients

Education ?

Medical School Score Rankings
Northwestern University (1970)
  • Currently 3 of 4 apples
Top 50%

Awards & Distinctions ?

Associations
American Board of Pathology

Affiliations ?

Dr. McCormick is affiliated with 4 hospitals.

Hospital Affilations

Score

Rankings

  • Nazareth Hospital
    2601 Holme Ave, Philadelphia, PA 19152
    • Currently 3 of 4 crosses
    Top 50%
  • Cape Regional Medical Center
    2 Stone Harbor Blvd, Cape May Court House, NJ 08210
    • Currently 1 of 4 crosses
  • Lourdes Medical Ctr Of Burlington Cnty
  • Our Lady Of Lourdes Med Cent
  • Publications & Research

    Dr. McCormick has contributed to 5 publications.
    Title Transcriptional Profile of Isoproterenol-induced Cardiomyopathy and Comparison to Exercise-induced Cardiac Hypertrophy and Human Cardiac Failure.
    Date January 2010
    Journal Bmc Physiology
    Excerpt

    Isoproterenol-induced cardiac hypertrophy in mice has been used in a number of studies to model human cardiac disease. In this study, we compared the transcriptional response of the heart in this model to other animal models of heart failure, as well as to the transcriptional response of human hearts suffering heart failure.

    Title The Formation of Endothelial Webs and Channels in Plasma Clot Culture.
    Date November 1984
    Journal Scanning Electron Microscopy
    Excerpt

    Rings of rat aorta cultured in plasma clots gave rise to microvascular networks. Scanning electron microscopy revealed that, in most cultures, the newly formed microvessels communicated with an endothelial-lined chamber which had developed around the aorta. The endothelial cells lining the wall of this chamber were elongated and frequently overlapped each other forming unicellular or multicellular bridges. The endothelium also produced solid bands and webs which spanned wide regions of the periaortic chamber and of the aortic lumen. Solid endothelial ropelike structures overran the openings of the newly formed vascular channels and connected the outer wall of the chamber with the aortic ring. Webs were composed of branching cords of spiraling endothelial cells with or without collagenized cores. Webs and bands formed as a result of the extensive surface remodeling of the fibrin clot by developing endothelial channels. These structures are reminiscent of the intimal bands and webs which develop in human blood vessels as a late sequela of the organization of thromboemboli.

    Title Renal Hemangiopericytoma: Surgical, Radiological and Pathological Implications.
    Date August 1984
    Journal The Journal of Urology
    Excerpt

    The first case of renal hemangiopericytoma presenting radiologically as a hypovascular mass is described. Preoperative diagnostic evaluation included ultrasonography, retrograde pyeloureterography, computerized tomography and angiography. Electron microscopy is helpful to distinguish this lesion from histologically similar juxtaglomerular cell tumors. Although renal hemangiopericytoma may appear benign on pathological examination it should be treated as a low grade malignancy and followed carefully.

    Title Radionuclide Imaging and Computed Tomography in Renal Oncocytoma.
    Date March 1981
    Journal Radiology
    Excerpt

    Renal oncocytoma is an apparently benign neoplasm that is being reported with increasing frequency. It is important to differentiate it from renal-cell carcinoma prior to surgery. Angiographic, CT, and ultrasound studies may suggest the diagnosis but are not pathognomonic. In 4 cases, 99mTc-glucoheptonate imaging of the renal tubules was performed; one patient was also scanned in 131I-orthoidohippurate. There was no evidence of radionuclide uptake by the tumor. Reasons for the lack of success in differentiating renal oncocytoma from renal-cell carcinoma are discussed.

    Title A Long Aaag Repeat Allele in the 5' Utr of the Err-γ Gene is Correlated with Breast Cancer Predisposition and Drives Promoter Activity in Mcf-7 Breast Cancer Cells.
    Date
    Journal Breast Cancer Research and Treatment
    Excerpt

    We sequenced the 5' UTR of the estrogen-related receptor gamma gene (ERR-γ) in ~500 patient and volunteer samples and found that longer alleles of the (AAAG)( n ) microsatellite were statistically and significantly more likely to exist in the germlines of breast cancer patients when compared to healthy volunteers. This microsatellite region contains multiple binding sites for a number of transcription factors, and we hypothesized that the polymorphic AAAG-containing sequence in the 5' UTR region of ERR-γ might modulate expression of ERR-γ. We found that the 369 bp PCR product containing the AAAG repeat drove expression of a reporter gene in estrogen receptor positive breast cancer cells. Our results support a role for the 5' UTR region in ERR-γ expression, which is potentially mediated via binding to the variable tandem AAAG repeat, the length of which correlates with breast cancer pre-disposition. Our study indicates that the AAAG tetranucleotide repeat polymorphism in ERR-γ gene 5' UTR region may be a new biomarker for genetic susceptibility to breast cancer.

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