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Obstetrician & Gynecologist (OB/GYN)
5 years of experience

Credentials

Education ?

Medical School Score
University of Hawaii (2006)
  •  

Affiliations ?

Dr. Zia is affiliated with 3 hospitals.

Hospital Affiliations

Score

Rankings

  • Swedish Medical Center - Cherry Hill
    747 Broadway, Seattle, WA 98122
    •  
    Top 25%
  • Swedish Edmonds Hospital
    21601 76th Ave W, Edmonds, WA 98026
    •  
    Top 50%
  • Swedish Medical Center - Ballard
    5300 Tallman Ave NW, Seattle, WA 98107
  • Publications & Research

    Dr. Zia has contributed to 4 publications.
    Title Pain Experienced Using Two Different Methods of Endometrial Biopsy: a Randomized Controlled Trial.
    Date April 2011
    Journal Obstetrics and Gynecology
    Excerpt

    To compare patient-reported pain, provider- reported ease of use, and tissue sampling adequacy between endometrial biopsy instruments.

    Title Andrew Taylor Still (1828-1917): Founder of Osteopathic Medicine.
    Date January 2008
    Journal Singapore Medical Journal
    Title Albrecht Von Graefe (1828-1870): Founder of Scientific Ophthalmology.
    Date November 2007
    Journal Singapore Medical Journal
    Title Poly(2-alkylacrylic Acid) Polymers Deliver Molecules to the Cytosol by Ph-sensitive Disruption of Endosomal Vesicles.
    Date July 2003
    Journal The Biochemical Journal
    Excerpt

    The permeability barrier posed by cell membranes represents a challenge for the delivery of hydrophilic molecules into cells. We previously proposed that poly(2-alkylacrylic acid)s are endocytosed by cells into acidified vesicles and are there triggered by low pH to disrupt membranes and release the contents of endosomes/lysosomes to the cytosol. If this hypothesis is correct, these polymers could be valuable in drug-delivery applications. The present paper reports functional comparisons of a family of three poly(2-alkylacrylic acid)s. Poly(2-propylacrylic acid) (PPAA), poly(2-ethylacrylic acid) (PEAA) and poly(2-methylacrylic acid) (PMAA) were compared in red-blood-cell haemolysis assays and in a lipoplex (liposome-DNA complex) assay. We also directly examined the ability of these polymers to disrupt endosomes and lysosomes in cultured human cells. Our results show that: (i) unlike membrane-disruptive peptides, the endosomal-disruptive ability of poly(2-alkylacrylic acid)s cannot necessarily be predicted from their haemolytic activity at low pH, (ii) PPAA (but not PEAA or PMAA) potently facilitates gene transfection by cationic lipoplexes and (iii) endocytosed poly(2-alkylacrylic acid)s are triggered by luminal acidification to selectively disrupt endosomes (not lysosomes) and release their contents to the cytosol. These results will facilitate the rational design of future endosomal-disrupting polymers for drug delivery.

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