Obstetrician & Gynecologist (OB/GYN), Pediatrician
6 years of experience

Accepting new patients
5303 Harry Hines Blvd
Oak Lawn, Dallas, TX 75390
214-648-2784
Locations and availability (3)

Education ?

Medical School Score Rankings
University of Pittsburgh (2004)
  • Currently 4 of 4 apples
Top 25%

Awards & Distinctions ?

Awards  
Patients' Choice Award (2013)
Compassionate Doctor Recognition (2013)

Affiliations ?

Dr. Escobar is affiliated with 7 hospitals.

Hospital Affilations

Score

Rankings

  • UT Southwestern University Hospital - Zale Lipshy
    5151 Harry Hines Blvd, Dallas, TX 75235
    • Currently 4 of 4 crosses
    Top 25%
  • UT Southwestern University Hospital - St. Paul
    5909 Harry Hines Blvd, Dallas, TX 75235
    • Currently 4 of 4 crosses
    Top 25%
  • Las Colinas Medical Center
    6800 N MacArthur Blvd, Irving, TX 75039
    • Currently 2 of 4 crosses
  • UT Southwestern St Paul Hospital
  • Baylor Grapevine Hospital
  • UT Southwestern Zale Lipshy Hospital
  • Irving Coppell Surgical Hospital
    400 W Lyndon B Johnson Fwy, Irving, TX 75063
  • Publications & Research

    Dr. Escobar has contributed to 6 publications.
    Title The Protein Kinase a Pathway Regulates Cyp17 Expression and Androgen Production in the Human Placenta.
    Date November 2011
    Journal The Journal of Clinical Endocrinology and Metabolism
    Excerpt

    Our previous work demonstrated that the human placenta expresses CYP17 and is capable of de novo production of C-19 steroids; thus, it has intrinsic capacity to generate estrogens without fetal or maternal steroid precursors.

    Title The Human Placenta Expresses Cyp17 and Generates Androgens De Novo.
    Date June 2011
    Journal The Journal of Clinical Endocrinology and Metabolism
    Excerpt

    The human placenta is believed to have insignificant CYP17 expression, rendering it dependent on the maternal and fetal compartments for the necessary androgenic precursors to yield the high levels of estrogens seen in pregnancy.

    Title 17α-hydroxylase (cyp17) Expression and Subsequent Androstenedione Production in the Human Ovary.
    Date February 2011
    Journal Reproductive Sciences (thousand Oaks, Calif.)
    Excerpt

    Traditionally, in women, only the theca cells in the ovary and the zona reticularis layer of the adrenal cortex are believed to synthesize androgens. Interestingly, their neighboring cell layers, the granulosa cells and the zona glomerulosa cells, respectively, do not produce androgens. Recent literature has highlighted the role of the activator protein (AP-1) transcription factor, c-Fos, in the dynamics of this structural and functional relationship. Differential expression of c-Fos is believed to result in distinct patterns of steroidogenesis among these compartments in both the ovary and the adrenal glands. Clinically, deficient c-Fos levels have been implicated in the pathogenesis of polycystic ovary syndrome (PCOS). In this review, we discuss the pivotal role of c-Fos in controlling the expression of CYP17 and hence androgen production in various organ systems throughout the human body.

    Title Molecular Mechanism for Repression of 17alpha-hydroxylase Expression and Androstenedione Production in Granulosa Cells.
    Date January 2010
    Journal The Journal of Clinical Endocrinology and Metabolism
    Excerpt

    According to the traditional two-cell two-gonadotropin model of follicular steroidogenesis, androgen production arises exclusively from theca cells. The granulosa cells, in turn, utilize androstenedione and testosterone, which are aromatized into estrone and estradiol, respectively. Differential expression of the activator protein-1 (AP-1) transcription factor, c-fos, has been postulated to result in distinct patterns of steroidogenesis in the theca and granulosa cell compartments. We hypothesize that c-fos functions to inhibit the production of 17alpha-hydroxylase 17,20 lyase (CYP17) in granulosa cells, thereby suppressing androgen synthesis.

    Title Partial Small Bowel Obstruction and Ileus Following Gynecologic Laparoscopy.
    Date March 2007
    Journal Journal of Minimally Invasive Gynecology
    Excerpt

    STUDY OBJECTIVE: To assess the incidence and management of partial small bowel obstruction (PSBO) and ileus after gynecologic endoscopy. DESIGN: Internet-based cross-sectional survey (Canadian Task Force classification II-3). MATERIAL AND METHODS: An online survey was distributed to gynecologic surgeons to collect information about frequency and management of ileus and PSBO after gynecologic laparoscopy. MEASUREMENTS AND MAIN RESULTS: Of the 58 physician respondents, 22 had managed at least 1 patient with PSBO or ileus after gynecologic laparoscopy. A total of 12 PSBOs and 14 patients experiencing ileus were identified for an overall incidence of 0.036%. Patients showed symptoms between 1 and 20 days postoperatively and had findings ranging from hypoactive (45%), to normal (30%), to hyperactive (25%) bowel sounds. Plain film radiographs (75%) were the most commonly used diagnostic modality followed by computed tomography (CT) scans of the abdomen. Most patients were initially managed with intestinal rest and nasogastric tube placement for 2 to 16 days. Fifty percent required a second procedure, with reported findings that included intestinal herniation (n = 7), bowel injury (n = 4), volvulus (n = 2), and urinoma (n = 1). CONCLUSION: Ileus and PSBO are rare findings after gynecologic laparoscopy. We identified 26 cases, most of which were initially managed conservatively. The majority of patients ultimately required a second operation. Surgeons should have a high index of suspicion when managing a patient with PSBO or ileus after gynecologic laparoscopy. Given the findings from the second procedures, CT scans would seem to be the diagnostic procedure of choice.

    Title Deletions in the Ac-iap1 Gene of the Baculovirus Acmnpv Occur Spontaneously During Serial Passage and Confer a Cell Line-specific Replication Advantage.
    Date January 2002
    Journal Virus Research
    Excerpt

    The PstI-I region of the Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV) genome was previously shown to be a frequent target of spontaneous deletions during serial virus passage in TN-368 cells (Kumar and Miller, Virus Res. 7 (1987) 335). Analysis of two of these serial passage mutants showed that a portion of the Ac-iap1 gene was deleted. To directly test the effect of loss of Ac-iap1, three different deletions in Ac-iap1 were introduced into recombinant viruses and the ability of these viruses to replicate was examined in two cell lines, TN-368 and SF-21, as well as in two species of insect larvae, Trichoplusia ni and Spodoptera frugiperda. The mutant viruses were indistinguishable from wild type or control revertant virus in their ability to infect larvae of either species. Moreover, no effect was seen on the rate of replication or the overall amounts of budded or occluded virus produced in cultured cells. However, in co-infection experiments using TN-368 cells, it was consistently observed that mutants lacking a functional Ac-iap1 gene out-competed control viruses carrying Ac-iap1. Interestingly, this replication advantage was only evident in the TN-368 cell line, the cell line used for the original serial passage experiments, and not in SF-21 cells.

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