Browse Health
Internist, Critical Care Specialist, Pulmonologist (lungs)
8 years of experience
Accepting new patients

Education ?

Medical School
Osmania Medical College (2002)
Foreign school

Awards & Distinctions ?

Associations
American Board of Internal Medicine

Affiliations ?

Dr. Kosuri is affiliated with 2 hospitals.

Hospital Affilations

Score

Rankings

  • Mercy Medical Center Merced
    Pulmonary Disease
    2740 M St, Merced, CA 95340
    • Currently 4 of 4 crosses
    Top 25%
  • Emanuel Medical Center
    Pulmonary Disease
    825 Delbon Ave, Turlock, CA 95382
    • Currently 2 of 4 crosses
  • Publications & Research

    Dr. Kosuri has contributed to 5 publications.
    Title Visual Vignette.
    Date September 2007
    Journal Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
    Title Preoperative Carbohydrate Antigen 19-9 is Most Predictive of Malignancy in Older Jaundiced Patients Undergoing Pancreatic Resection.
    Date October 2006
    Journal Pancreas
    Excerpt

    OBJECTIVES: Given the increased detection of occult pancreatic neoplasms with modern imaging modalities, it is often difficult to determine the risk of malignancy before curative pancreatectomy. We reviewed patients who underwent pancreatectomy to determine factors predictive of malignancy with particular attention to the serum marker carbohydrate antigen 19-9 (CA19-9). METHODS: One hundred eighteen patients underwent radical pancreatectomy for malignant (n = 59) or benign (n = 59) pancreatic lesions. Demographic data, preoperative CA19-9 levels (normal, <37 U/mL), and follow-up were obtained from patient charts. Logistic regression analysis was used to determine univariate and multivariate predictors of malignancy. RESULTS: Significant multivariate predictors of malignancy were increased CA19-9, age older than 50 years, and preoperative jaundice. The sensitivity and specificity of increased preoperative CA19-9 alone were 71% and 83%, respectively. The combination of age older than 50 years and jaundice was a more accurate predictor than CA19-9 (sensitivity, 76%; specificity, 92%). Increased CA19-9 was highly specific (97%) for malignancy in older jaundiced patients or when the preoperative level was greater than 150 U/mL. CONCLUSIONS: Age and preoperative jaundice are more predictive of malignancy than CA19-9 alone unless levels are greater than 150 U/mL. Preoperative CA19-9 levels should be interpreted within the context of these other clinical factors.

    Title Updates and Controversies in the Treatment of Pancreatic Cancer.
    Date April 2006
    Journal Clinical Advances in Hematology & Oncology : H&o
    Excerpt

    Despite the many advances in oncology over the last few decades, almost all patients with pancreatic cancer eventually die of the disease. Recent advances, however, have led to the development of more effective therapies. In pancreatic cancer, as in many other malignancies, significant progress in the understanding of important molecular processes associated with the development and progression of the disease is helping tailor more effective treatment strategies. Molecularly targeted agents are offering hope for their potential role in helping translate the improved activity of combination chemotherapy into improved survival. This article summarizes the data from studies that established standards of care and others that created controversy, and reviews novel treatment strategies for this intractable disease.

    Title Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain.
    Date August 2000
    Journal Journal of Virology
    Excerpt

    Vpx is a virion-associated protein of human immunodeficiency virus type 2 (HIV-2) and simian immunodeficiency viruses. The yeast two-hybrid system was used to identify invariant chain (Ii) as a cellular protein that interacts with HIV-2 Vpx. Vpx-Ii interaction was confirmed in cell-free reactions using bacterially expressed glutathione S-transferase fusion proteins and by coimmunoprecipitation in transfected and infected cells. In chronically infected cells expressing Vpx, Ii levels were markedly decreased, presumably due to enhanced degradation. These findings suggest that Vpx may disrupt major histocompatibility complex class II antigen presentation.

    Title Seizures As the First Manifestation of Chromosome 22q11.2 Deletion Syndrome in a 40-year Old Man: a Case Report.
    Date
    Journal Journal of Medical Case Reports
    Excerpt

    ABSTRACT: BACKGROUND: The microdeletion of chromosome 22q11.2 is the most common human deletion syndrome. It typically presents early in life and is rarely considered in adult patients. As part of the manifestations of this condition, patients can have parathyroid glandular involvement ranging from hypocalcemic hypoparathyroidism to normocalcemia with normal parathryroid hormone levels. The first manifestation of the syndrome might be seizures due to profound hypocalcemia. CASE PRESENTATION: A 40-year-old man without significant past medical history presented with a new-onset generalized tonic-clonic seizure. He had no personal history of hypocalcemia or seizures. Physical examination was remarkable for short stature, hypertelorism, prominent forehead and nasal voice. His initial laboratory examination showed hypocalcemia (Calcium 5.2 mg/dl and Calcium ionized 0.69 mmol/l) with hypoparathyroidism (Parathyroid hormone intact < 2.5 pg/ml. NV: 14-72 pg/ml). Urine Calcium was 3 mg/dl on a spot and 88 mg in a 24-hour urine collection (NV: 100-300 mg/24 hs). The electrocardiogram showed a prolonged corrected QT interval. Echocardiogram, abdominal ultrasound and electroencephalogram were normal. A computer tomography of the brain showed basal ganglia calcification. The subtle physical findings and the presence of idiopathic hypoparathyroidism motivated the performance of fluorescent in situ hybridization which demonstrated a microdeletion on one of the homologs 22q11.2. The patient was treated with calcium citrate and calcitriol with good response. CONCLUSION: Microdeletion of chromosome 22q11.2 is among the most clinically variable syndromes, with more than 180 features associated with the deletion. It has a variable phenotypical expression, requiring a high level of awareness for its early diagnosis. Seizures, related to marked hypocalcemia due to idiopathic hypoparathyroidism, might be the presenting feature in an adult patient with this syndrome.

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