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Otolaryngologist (ear, nose, throat)
8 years of experience
Video profile
Accepting new patients

Education ?

Medical School Score
Thomas Jefferson University (2002)
  • Currently 2 of 4 apples

Awards & Distinctions ?

Awards  
Castle Connolly's Top Doctors™ (2013)
Appointments
University of Pennsylvania
Assistant Professor of Otorhinolaryngology Head and Neck Surgery
Associations
American Academy of Otolaryngology: Head and Neck Surgery
American Board of Otolaryngology
American College of Surgeons
American Head and Neck Society

Affiliations ?

Dr. Malloy is affiliated with 7 hospitals.

Hospital Affilations

Score

Rankings

  • Hospital of the University of PA
    Otolaryngology
    3400 Spruce St, Philadelphia, PA 19104
    • Currently 4 of 4 crosses
    Top 25%
  • University of Michigan Hospitals & Health Centers
    Otolaryngology
    1500 E Medical Center Dr, Ann Arbor, MI 48109
    • Currently 4 of 4 crosses
    Top 25%
  • Pennsylvania Hospital University PA Health System
    Otolaryngology
    800 Spruce St, Philadelphia, PA 19107
    • Currently 2 of 4 crosses
  • Pennsylvania Hospital
  • Clinical Practices of the University of Pennsylvania
  • University of Michigan Medical Center
  • Ann Arbor Veterans Affairs Medical Center
    2215 Fuller Rd, Ann Arbor, MI 48105
  • Publications & Research

    Dr. Malloy has contributed to 14 publications.
    Title Orl Emergencies Boot Camp: Using Simulation to Onboard Residents.
    Date November 2011
    Journal The Laryngoscope
    Excerpt

    Incoming otolaryngology residents are expected to triage and manage airway, bleeding, and other emergencies with little prior experience. Simulation-based education has become increasingly important as it provides tools to develop psychomotor skills and judgment early in residency, using realistic experiences while eliminating patient risk. We hypothesize that a Boot Camp course emphasizing basic otolaryngology management will increase participants' confidence and be perceived as useful in developing their knowledge, technical skills, self-confidence, and improving clinical performance, both immediately and 6 months following the course.

    Title Maxillomandibular-labial Reconstruction: an Autogenous Transplant As an Alternative to Allogenic Face Transplantation.
    Date January 2011
    Journal Plastic and Reconstructive Surgery
    Title Thoracodorsal Artery Scapular Tip Autogenous Transplant: Vascularized Bone with a Long Pedicle and Flexible Soft Tissue.
    Date November 2010
    Journal Archives of Otolaryngology--head & Neck Surgery
    Excerpt

    To demonstrate that the 3 reconstructive advantages of the thoracodorsal artery scapular tip transplant (Tdast), a long pedicle, independently mobile tissue components, and the 3-dimensional nature of the scapular tip, will improve the quality and success of complex reconstructions by avoiding vein grafting, preventing the need for 2 separate transplants, and facilitating bony inset.

    Title Lack of Association of Ct Findings and Surgical Drainage in Pediatric Neck Abscesses.
    Date April 2008
    Journal International Journal of Pediatric Otorhinolaryngology
    Excerpt

    OBJECTIVE: To evaluate the relationship between neck abscess characteristics on computerized tomography (CT) scan and surgical drainage in pediatric patients. METHODS: Retrospective data warehouse review identified 43 children younger than 19 years admitted to a tertiary care pediatric hospital during the first quarters of 2000 through 2003 who underwent CT imaging for suspicion of head and neck abscesses involving the neck; face; and peritonsillar, retropharyngeal, and parapharyngeal spaces. A total of 45 scans were graded by a radiologist blinded to management. Thickness of the prevertebral soft tissue; location, dimensions, and degree of enhancement of the abscess; patient age; steroid and preadmission antibiotic use; and surgical intervention were recorded. RESULTS: Surgical drainage was performed in 32 of 43 patients (74%). We found no significant correlation between prevertebral soft tissue thickness, abscess dimensions or enhancement on CT scan, and surgical drainage. There was no significant association between surgical drainage and patient age, administration of steroids, or preadmission antibiotic use. CONCLUSIONS: Neck abscess appearance on CT scan did not predict surgical drainage, although prevertebral soft tissue thickness and abscess dimensions may be important features. Abscess enhancement, patient age, and the use of steroids and prehospitalization antibiotics were not found to correlate with surgical drainage.

    Title Pathology and Cytologic Features of Thyroid Neoplasms.
    Date March 2008
    Journal Surgical Oncology Clinics of North America
    Excerpt

    Most thyroid neoplasms arise from follicular cells and are well differentiated. Anaplastic and poorly differentiated carcinomas are rare and have a high mortality. Five percent of tumors are of C-cell origin, and 20% to 25% of these are hereditary. Thyroid lymphoma is rare and occurs in the setting of Hashimoto's thyroiditis. Fine needle aspiration biopsy is the best diagnostic tool to classify thyroid neoplasms.

    Title Ultrasound-guided Contrast-enhanced Sentinel Node Biopsy of the Head and Neck in a Porcine Model.
    Date December 2007
    Journal Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-head and Neck Surgery
    Excerpt

    OBJECTIVE: To test the feasibility of contrast-enhanced ultrasound (CEUS)-guided sentinel lymph node biopsy (SNB) of the head and neck in a porcine model. STUDY DESIGN AND SETTING: In this prospective, nonrandomized study, methylene blue and Sonazoid were injected into the lateral tongue or floor of mouth (FOM) of four swine. Real-time CEUS was used to identify contrast in the lymphatic channels flowing to the sentinel lymph node (SLN). Endoscopic or open SNB was performed. Neck dissection was then performed, and the residual nodal packet was examined for remaining contrast-enhancing or blue dye-stained nodes. RESULTS: In all eight procedures, the SLN was visualized with ultrasound and blue dye. Seven procedures identified a single SLN, and one identified two SLNs. Subsequent neck dissections revealed no other nodes containing methylene blue or contrast in the nodal specimen or operative bed. CONCLUSION/SIGNIFICANCE: CEUS-guided SNB of the head and neck in swine is feasible, with success comparable to blue dye-guided SNB. This technique may offer several advantages over traditional techniques, and warrants further study.

    Title Feasibility of Endoscopic Sentinel Node Biopsy in the Porcine Neck.
    Date June 2007
    Journal Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-head and Neck Surgery
    Excerpt

    OBJECTIVE: To assess the feasibility of endoscopic sentinel node biopsy (SNB) using a tracer dye in a pig model. STUDY DESIGN AND SETTING: This was a prospective, nonrandomized experimental study in Yorkshire pigs. The posterolateral tongues of three animals were injected with a one-to-one solution of carbon dye to methylene blue dye. Endoscopic SNB was performed and stained lymph nodes identified and retrieved, followed by an open dissection to recover any remaining nodes. Specimens were analyzed by a pathologist for staining, size, and structural integrity. RESULTS: Six unilateral endoscopic SNBs were performed without complications. During endoscopic dissection, gross blue-staining of a sentinel node was noted in four of six dissections (66%). One of six sentinel nodes demonstrated histologic evidence of carbon staining. Structural integrity of all nodes was intact upon histological evaluation. CONCLUSION/SIGNIFICANCE: Endoscopic cervical SNB in pigs is feasible but has limitations based on lymph node size and reliability of tracer dyes. Further study is warranted to perfect tracer dyes and retrieval methods to improve this technique.

    Title Cxcr1 and Cxcr2 Activation and Regulation. Role of Aspartate 199 of the Second Extracellular Loop of Cxcr2 in Cxcl8-mediated Rapid Receptor Internalization.
    Date June 2007
    Journal The Journal of Biological Chemistry
    Excerpt

    CXCL8 (interleukin-8) interacts with two receptors, CXCR1 and CXCR2, to activate leukocytes. Upon activation, CXCR2 internalizes very rapidly relative to CXCR1 ( approximately 90% versus approximately 10% after 5 min). The C termini of the receptors have been shown to be necessary for internalization but are not sufficient to explain the distinct kinetics of down-regulation. To determine the structural determinant(s) that modulate receptor internalization, various chimeric and point mutant receptors were generated by progressively exchanging specific domains or amino acids between CXCR1 and CXCR2. The receptors were stably expressed in rat basophilic leukemia 2H3 cells and characterized for receptor binding, intracellular Ca(2+) mobilization, phosphoinositide hydrolysis, phosphorylation, internalization, and MAPK activation. The data herein indicate that the second extracellular loop (2ECL) of the receptors is critical for the distinct rate of internalization. Replacing the 2ECL of CXCR2 with that of CXCR1 (B(2ECL)A) or Asp(199) with its CXCR1 valine counterpart (B(D199V)A) delayed CXCR2 internalization similarly to CXCR1. Replacing Asp(199) with Asn (B(D199N)) restored CXCR2 rapid internalization. Structure modeling of the 2ECL of the receptors also suggested that Asp(199) plays a critical role in stabilizing and modulating CXCR2 rapid internalization relative to CXCR1. B(D199N) internalized rapidly but migrated as a single phosphorylated form like CXCR1 ( approximately 75 kDa), whereas B(2ECL)A and B(D199V)A showed slow and fast migrating forms like CXCR2 ( approximately 45 and approximately 65 kDa, respectively) but internalized like CXCR1. These data further undermine the role of receptor oligomerization in CXCL8 receptor internalization. Like CXCR1, B(D199V)A also induced sustained ERK activation and cross-desensitized Ca(2+) mobilization to CCR5 relative to B(D199N) and CXCR2. Altogether, the data suggest that the 2ECL of the CXCL8 receptors is important in modulating their distinct rate of down-regulation and thereby signal length and post-internalization activities.

    Title Zolpidem Tartrate Use As Contributory Factor in Sinus Disease.
    Date November 2006
    Journal Sleep
    Title Autograft Versus Allograft in Degenerative Cervical Disease.
    Date February 2002
    Journal Clinical Orthopaedics and Related Research
    Excerpt

    Cervical spondylosis, common among people older than 50 years, may produce symptoms of cervical radiculopathy, myelopathy, or both. When patients with degenerative cervical disease require surgery, an anterior decompression of the neural elements and reconstruction of the anterior column with allograft or autograft is common. Allograft incorporates more slowly and less completely than autogenous bone graft, although harvest of autograft from the anterior iliac crest or the middle 1/3 of the fibula may be associated with postoperative morbidity. Overall, higher rates of fusion have been reported with autograft than allograft. However, similar fusion rates have been reported among nonsmokers having single-level anterior cervical interbody fusions. For patients requiring multilevel reconstruction surgery, fusion rates of approximately 100% have been achieved using autogenous strut grafts from the iliac crest and fibula, with a lower rate of incorporation for fibula allograft. The potential for a patient with a nonunion requiring additional operative treatment must be weighed against the potential for graft-related complications when choosing between autograft and allograft for anterior cervical reconstruction.

    Title The Presentation of Self and Allogeneic Mhc Peptides to T Lymphocytes.
    Date November 1998
    Journal Human Immunology
    Excerpt

    The presentation of donor-derived MHC peptides by recipient APCs to T cells is an essential component of the rejection of allografts (indirect allorecognition). Initial alloreactive T cell response is confined to a few well processed and presented dominant determinants on donor MHC. However, during long-term graft rejection, T cell response spreads to formerly poorly presented cryptic allogeneic MHC peptides. This phenomenon is likely to play an important role in the amplification and the perpetuation of the rejection process. Additionally, we present evidence that T cell repertoire selection to allogeneic MHC peptides is acquired via recognition of self-MHC peptides presented in the thymus during ontogeny. Supporting this view, we have shown that indirect alloresponses can lead to self-T cell tolerance breakdown to cross-reactive determinants on self-MHC molecules or alternatively that sensitization of recipients to self-MHC peptides can lead to accelerated graft rejection. It is therefore essential to determine the factors which govern the processing and presentation of self and allogeneic MHC molecules and to elucidate the mechanisms regulating subsequent T cell responses in order to design antigen-specific based immune therapies in transplantation.

    Title The Influence of Acridine Dyes and Caffeine on Recovery from Ultraviolet Damage in Eudorina Elegans.
    Date February 1976
    Journal Canadian Journal of Microbiology
    Excerpt

    Caffeine and the acridine dyes, acridine orange and acriflavine, were used to examine the repair potential in Eudorina elegans following ultraviolet irradiation. Acridines blocked photoreactivation primarily as a result of absorption of photoreactivating wavelengths, but acridines did not influence dark survival. Therefore, an acridine-sensitive excision-resynthesis-repair process is absent in Eudorina. Caffeine decreased both dark and light survival, the latter only after relatively high doses of ultraviolet light were used for inactivation. The caffeine-sensitive repair process appears to function most actively when the organisms are engaged in DNA synthesis, indicating that a postreplication-repair system exists in Eudorina. However, the data suggest that a repair system not associated with the DNA synthetic phases may also exist.

    Title Radioimmunoassay for Gastric Inhibitory Polypeptide.
    Date April 1974
    Journal Gastroenterology
    Title 4-nitroquinoline I-oxide Induced Lethality and Repair in the Alga, Eudorina Elegans.
    Date January 1974
    Journal Mutation Research

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