Obstetrician & Gynecologist
4 years of experience

Accepting new patients
Sugar Land Women's Health
17510 W Grand Pkwy S
Sugar Land, TX 77479
Locations and availability (2)

Education ?

Medical School Score Rankings
The University of Texas at Houston (2006)
  • Currently 3 of 4 apples
Top 50%

Affiliations ?

Dr. Phillips is affiliated with 5 hospitals.

Hospital Affilations

  • Methodist Sugar Land Hospital *
  • Memorial Hermann Healthcare System *
  • Presbytarian Flower Mound
  • Denton Regional Medical Center
  • North Texas Medical Center
    1900 Hospital Blvd, Gainesville, TX 76240
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Phillips has contributed to 1 publication.
    Title Structural Studies Examining the Substrate Specificity Profiles of Pc-plc(bc) Protein Variants.
    Date June 2007
    Journal Archives of Biochemistry and Biophysics

    The phosphatidylcholine preferring phospholipase C from Bacillus cereus (PC-PLC(Bc)) catalyzes the hydrolysis of phospholipids in the following order of preference: phosphatidylcholine (PC)>phosphatidylethanolamine (PE)>phosphatidylserine (PS). In previous work, mutagenic, kinetic, and crystallographic experiments suggested that varying the amino acids at the 4th, 56th, and 66th positions had a significant influence upon the substrate specificity profile of PC-PLC(Bc). Here, we report the crystal structures of the native form of several PC-PLC(Bc) variants that exhibited altered substrate specificities for PC, PE, and PS at maximum resolutions of 1.90-2.05 Angstrom. Comparing the structures of these variants to the structure of the wild-type enzyme reveals only minor differences with respect to the number and location of active site water molecules and the side chain conformations of residues at the 4th and 56th positions. These results suggest that subtle changes in steric and electronic properties in the substrate binding site of PC-PLC(Bc) are responsible for the significant changes in substrate selectivity.

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