Family Practice
32 years of experience

Accepting new patients
North Scottsdale
8575 E Princess Dr
Scottsdale, AZ 85255
480-699-7999
Locations and availability (2)

Education ?

Medical School Score
Philadelphia College of Osteopathic Medicine (1978)
  • Currently 1 of 4 apples

Awards & Distinctions ?

Awards  
Patients' Choice Award (2011 - 2012)
Compassionate Doctor Recognition (2011 - 2012)
Associations
American Osteopathic Association

Affiliations ?

Dr. Blume is affiliated with 5 hospitals.

Hospital Affilations

Score

Rankings

  • Arizona Heart Hospital
    1930 E Thomas Rd, Phoenix, AZ 85016
    • Currently 4 of 4 crosses
    Top 25%
  • Paradise Valley Hospital *
    3929 E Bell Rd, Phoenix, AZ 85032
    • Currently 4 of 4 crosses
    Top 25%
  • Arrowhead Community
    18701 N 67th Ave, Glendale, AZ 85308
    • Currently 4 of 4 crosses
    Top 25%
  • Scottsdale Healthcare-Shea *
    9003 E Shea Blvd, Scottsdale, AZ 85260
    • Currently 4 of 4 crosses
    Top 25%
  • West Valley Hospital Medical Center
    13677 W McDowell Rd, Goodyear, AZ 85395
    • Currently 3 of 4 crosses
    Top 50%
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Blume has contributed to 29 publications.
    Title Transverse-momentum and Pseudorapidity Distributions of Charged Hadrons in Pp Collisions at Square Root of S = 7 Tev.
    Date January 2011
    Journal Physical Review Letters
    Excerpt

    Charged-hadron transverse-momentum and pseudorapidity distributions in proton-proton collisions at square root of s = 7  TeV are measured with the inner tracking system of the CMS detector at the LHC. The charged-hadron yield is obtained by counting the number of reconstructed hits, hit pairs, and fully reconstructed charged-particle tracks. The combination of the three methods gives a charged-particle multiplicity per unit of pseudorapidity dN(ch)/dη|(|η|<0.5) = 5.78 ± 0.01(stat) ± 0.23(syst) for non-single-diffractive events, higher than predicted by commonly used models. The relative increase in charged-particle multiplicity from square root of s = 0.9 to 7 TeV is [66.1 ± 1.0(stat) ± 4.2(syst)]%. The mean transverse momentum is measured to be 0.545 ± 0.005(stat) ± 0.015(syst)  GeV/c. The results are compared with similar measurements at lower energies.

    Title First Measurement of Bose-einstein Correlations in Proton-proton Collisions at √s=0.9 and 2.36 Tev at the Lhc.
    Date January 2011
    Journal Physical Review Letters
    Excerpt

    Bose-Einstein correlations have been measured using samples of proton-proton collisions at 0.9 and 2.36 TeV center-of-mass energies, recorded by the CMS experiment at the CERN Large Hadron Collider. The signal is observed in the form of an enhancement of pairs of same-sign charged particles with small relative four-momentum. The size of the correlated particle emission region is seen to increase significantly with the particle multiplicity of the event.

    Title Host-derived Glucose and Its Transporter in the Obligate Intracellular Pathogen Toxoplasma Gondii Are Dispensable by Glutaminolysis.
    Date August 2009
    Journal Proceedings of the National Academy of Sciences of the United States of America
    Excerpt

    Toxoplasma gondii, as an obligate intracellular and promiscuous pathogen of mammalian cells, utilizes host sugars for energy and to generate glycoconjugates that are important to its survival and virulence. Here, we report that T. gondii glucose transporter (TgGT1) is proficient in transporting mannose, galactose, and fructose besides glucose, and serves as a major hexose transporter at its plasma membrane. Toxoplasma harbors 3 additional putative sugar transporters (TgST1-3), of which TgST2 is expressed at its surface, whereas TgST1 and TgST3 are intracellular. Surprisingly, TgGT1 and TgST2 are nonessential to the parasite as their ablations inflict only a 30% or no defect in its intracellular growth, respectively. Indeed, Toxoplasma can also tolerate the deletion of both genes while incurring no further growth phenotype. Unlike Deltatgst2, the modest impairment in Deltatggt1 and Deltatggt1/Deltatgst2 mutants is because of a minor delay in their intracellular replication, which is a direct consequence of the abolished import of glucose. The Deltatggt1 displays an attenuated motility in defined minimal media that is rescued by glutamine. TgGT1-complemented parasites show an entirely restored growth, motility, and sugar import. The lack of exogenous glucose in Deltatggt1 culture fails to accentuate its intrinsic growth defect and prompts it to procure glutamine to sustain its metabolism. Unexpectedly, in vivo virulence of Deltatggt1 in mice remains unaffected. Taken together, our data demonstrate that glucose is nonessential for T. gondii tachyzoites, underscore glutamine is a complement substrate, and provide a basis for understanding the adaptation of T. gondii to diverse host cells.

    Title No Association Between Systemic Sclerosis and C77g Polymorphism in the Human Ptprc (cd45) Gene.
    Date December 2008
    Journal The Journal of Rheumatology
    Excerpt

    The functional variant C77G (rs17612648) of PTPRC (CD45) was described to confer risk for systemic sclerosis (SSc) in German Caucasians. We analyzed this association in an independent, larger German cohort.

    Title Epiphytic Bacterial Community Composition on Two Common Submerged Macrophytes in Brackish Water and Freshwater.
    Date June 2008
    Journal Bmc Microbiology
    Excerpt

    Plants and their heterotrophic bacterial biofilm communities possibly strongly interact, especially in aquatic systems. We aimed to ascertain whether different macrophytes or their habitats determine bacterial community composition. We compared the composition of epiphytic bacteria on two common aquatic macrophytes, the macroalga Chara aspera Willd. and the angiosperm Myriophyllum spicatum L., in two habitats, freshwater (Lake Constance) and brackish water (Schaproder Bodden), using fluorescence in situ hybridization. The bacterial community composition was analysed based on habitat, plant species, and plant part.

    Title Quality-based Registration and Reconstruction of Optical Tomography Volumes.
    Date January 2008
    Journal Medical Image Computing and Computer-assisted Intervention : Miccai ... International Conference on Medical Image Computing and Computer-assisted Intervention
    Excerpt

    Ultramicroscopy, a novel optical tomographic imaging modality related to fluorescence microscopy, allows to acquire cross-sectional slices of small specially prepared biological samples with astounding quality and resolution. However, scattering of the fluorescence light causes the quality to decrease proportional to the depth of the currently imaged plane. Scattering and beam thickness of the excitation laser light cause additional image degradation. We perform a physical simulation of the light scattering in order to define a quantitative function of image quality with respect to depth. This allows us to establish 3D-volumes of quality information in addition to the image data. Volumes are acquired at different orientations of the sample, hence providing complementary regions of high quality. We propose an algorithm for rigid 3D-3D registration of these volumes incorporating voxel quality information, based on maximizing an adapted linear correlation term. The quality ratio of the images is then used, along with the registration result, to create improved volumes of the imaged object. The methods are applied on acquisitions of a mouse brain and mouse embryo to create outstanding three-dimensional reconstructions.

    Title A New and General Method for Blind Shift-variant Deconvolution of Biomedical Images.
    Date January 2008
    Journal Medical Image Computing and Computer-assisted Intervention : Miccai ... International Conference on Medical Image Computing and Computer-assisted Intervention
    Excerpt

    We present a new method for blind deconvolution of multiple noisy images blurred by a shift-variant point-spread-function (PSF). We focus on a setting in which several images of the same object are available, and a transformation between these images is known. This setting occurs frequently in biomedical imaging, for example in microscopy or in medical ultrasound imaging. By using the information from multiple observations, we are able to improve the quality of images blurred by a shift-variant filter, without prior knowledge of this filter. Also, in contrast to other work on blind and shift-variant deconvolution, in our approach no parametrization of the PSF is required. We evaluate the proposed method quantitatively on synthetically degraded data as well as qualitatively on 3D ultrasound images of liver. The algorithm yields good restoration results and proves to be robust even in presence of high noise levels in the images.

    Title Who Should Own Scientific Papers?
    Date September 1998
    Journal Science (new York, N.y.)
    Title Comparison of Dipyridamole-echocardiography with Dipyridamole-thallium Scintigraphy for the Diagnosis of Myocardial Ischemia.
    Date September 1991
    Journal Clinical Nuclear Medicine
    Excerpt

    After an intravenous infusion of dipyridamole (0.56 mg/kg), we performed both echocardiography and thallium scintigraphy in 63 patients who were referred for known or suspected coronary artery disease. Of those patients, 25 returned for coronary arteriography within 1 month after the tests, thus forming the study group for this report. Sensitivity for detection of coronary artery disease, when analyzed region-by-region, was 80% for thallium scintigraphy and 57% for echocardiography, whereas specificity was 85% and 98%, respectively. When evaluating individual patients for the presence or absence of ischemia, we found a sensitivity of 95% for scintigraphy and 58% for echocardiography; corresponding specificities were 50% and 100%. By using arteriography as the gold standard for comparison, it appears that thallium scintigraphy has a significantly higher sensitivity but lower specificity for the detection of coronary artery disease than does echocardiography. Echocardiography may, however, be a useful adjunct to thallium scintigraphy in the evaluation of patients with coronary artery disease.

    Title The Simian Immunodeficiency Virus (siv) Rev Gene Regulates Env Expression.
    Date December 1990
    Journal Journal of Medical Primatology
    Excerpt

    The rev gene product is a trans-acting nuclear regulatory protein that is essential for AIDS virus replication. To define the effect of the SIV rev gene on its gp160 expression, two SV40 constructs have been made: pBC17 is a rev+env+ construct, and pBD21 is a rev-env+ construct. After transfecting the constructs into COS-1 cells, RNA, protein, syncytium formation, and monoclonal antibody blocking assays were performed. The results indicated that the SIV rev gene positively influenced the level of full-length env mRNA and was required for expression of SIV gp160.

    Title Coexpression of Biologically Active Simian Immunodeficiency Virus (siv) Rev and Env in an Sv40 System: the Siv Rev Gene Regulates Env Expression.
    Date August 1990
    Journal Virology
    Excerpt

    The coexpression of biologically active simian immunodeficiency virus (SIV) Rev and Env gene products was obtained in COS-1 cells from a single SIV subgenomic segment (which contains both exons of rev and the entire env gene) cloned into a SV40-directed vector. The SIVsm Rev trans-activated the expression of the full-length env mRNA and was required for the production of envelope glycoproteins. Furthermore, the alignment of the structural conservation of the Rev functional domains among all HIV and SIV was analyzed.

    Title Characterization of the Simian Adenovirus Type 30 Inverted Terminal Repeat.
    Date December 1989
    Journal Gene
    Excerpt

    The presence of an inverted terminal repeat (ITR), which plays an important role in the initiation of DNA replication, is one of the characteristic properties of adenoviruses (Ads). We have established the nucleotide (nt) sequences for the ITR of simian adenovirus type 30 (SV30), a subgroup-III oncogenic virus. This repeat consists of 185 nt, representing the longest ITR found in an Ad so far. It contains multiple copies of internal repeats, as well as the consensus sequences of the putative binding sites for replication and transcription factors. The conserved features of the known ITRs are also found in SV30. Interestingly, the ITR of SV30 is more closely related to that of Ad5 (human), than to that of SA7 (simian).

    Title Isolation of a Human Cdna of Urokinase and Its Expression in Cos-1 Cells.
    Date April 1989
    Journal Gene
    Excerpt

    The cDNA encoding human urokinase (UK) has been isolated from a cDNA library prepared from human normal fibroblast (WI38) cells, which had been stimulated by endothelial cell growth factor and heparin. This cDNA was sequenced and found to contain a few silent substitutions, thus encoding the same amino acids as deduced from the published genomic sequence of UK. After modification, the cDNA of UK was inserted into a transient expression vector and used to transfect COS-1 cells. The recombinant UK protein (rUK) in the serum-free medium of transfected COS-1 cells was characterized by biochemical and functional assays. These studies indicated that rUK from COS-1 cells is glycosylated, enzymatically active, and very similar to native single-chain plasminogen activator (scuPA). Therefore, such rUK can be a convenient source of scuPA for any further studies.

    Title [heart Position As a Determinant of the Voltage of the R Wave in Healthy Subjects].
    Date February 1989
    Journal Archivos Del Instituto De Cardiología De México
    Excerpt

    Although many factors have been reported to change the R wave amplitude of the electrocardiogram, the direct measurement without any consideration, has been the method of choice, which leads to controversial findings. We hypothesized that body mass index and heart position are the main modifiers of the R wave amplitude. To test this hypothesis 80 normal subjects were studied with standard electrocardiograms in which correlation with constitutional variables were performed and were also analyzed according to the electrocardiographic heart position. R wave amplitude showed a non-significant inverse relationship to body mass except in severe overweight subjects (p less than 0.05). When analyzed by position, levorotated and S1, S2, S3 hearts showed a significant increase in R wave voltage whereas horizontal and dextrorotated ones showed a diminished amplitude (p less than 0.01) independent of body weight. There was no relation between R wave voltage and body surface. We conclude that: Body mass is not an important modifier of R wave amplitude in thin, normal and light overweight subjects. Heart position may induce significant variation of R wave voltage according to the degree of the projection of the left ventricular electric field to the anterior thoracic surface.

    Title The Core Gene of Hepatitis B Virus; Subtype Adw2.
    Date October 1988
    Journal Nucleic Acids Research
    Title [animal Experiment Studies of Hemostasis Using the Fibrinogen Adhesive System on the Liver and Spleen in Coagulation Disorders].
    Date May 1988
    Journal Zeitschrift Für Experimentelle Chirurgie, Transplantation, Und Künstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Für Chirurgie Der Ddr
    Excerpt

    Fresh resection areas after partial resection of liver and lien in rabbits were repaired and sealed by a fibrin film on conditions of hemorrhagic tendency and increased fibrinolysis. A strong damage in the wound area in the same way as in organic injury originates from these pathologic conditions. A premature demarcation of the external wound strata especially in raised fibrinolysis takes place by reason of the parenchymal necrosis though the fibrinogen is cross-linked to an intact film independent of the common circulation and clotting relations. An abundant wound revision is recommended before using the fibrin adhesive to prevent an after-bleeding.

    Title [the Auxiliary Transplantation of a Portion of Liver in an Animal Experiment].
    Date April 1988
    Journal Zeitschrift Für Experimentelle Chirurgie, Transplantation, Und Künstliche Organe : Organ Der Sektion Experimentelle Chirurgie Der Gesellschaft Für Chirurgie Der Ddr
    Excerpt

    The authors inform about a model for auxiliary liver part transplantation in pig. Intra-abdominal narrowness which can lead to failure of the transplant can avoided by this model. In the transplant was carried out an extensive left resection with purse-string ligature of all visible vessels and cystic ducts. The resection surface is sealed by a tissue adhesive. An auxiliary transplanted part of the liver can also operate on a heterotopic location of the organism.

    Title [animal Experiment Studies of the Effectiveness of Fibrin Glue in the Management of Injuries of the Achilles Tendon].
    Date October 1987
    Journal Beiträge Zur Orthopädie Und Traumatologie
    Title [carcinoid Tumor of the Intestinal Tract].
    Date July 1986
    Journal Zeitschrift Für ärztliche Fortbildung
    Title [studies on the Extraction of Biologically Active Vasopressin from Plasma (author's Transl)].
    Date October 1981
    Journal Die Pharmazie
    Title [effect of Discontinuous Hemorrhage on Plasma and Cerebrospinal Fluid Vasopressin Concentration in Anesthesized Rabbits].
    Date October 1981
    Journal Acta Biologica Et Medica Germanica
    Excerpt

    Repeated withdrawal of 15 ml arterial blood at 10 min intervals produced marked hypovolaemia and hypotension with plasma vasopressin concentration increasing exponentially from 53 microE/ml to more than 700 microE/ml contrary to the hypovolaemia. After the first blood withdrawal there exists a linear correlation between the increase of the plasma vasopressin concentration and the decrease of the mean arterial blood pressure. With 61.5 microE/ml the cerebrospinal fluid withdrawn following the last bleeding likewise showed a very high vasopressin level. After extraction of the hormone from plasma and cerebrospinal fluid the vasopressin concentration was determined by means of the antidiuretic bioassay in the water-loaded rat.

    Title [screening Test for Adsorbing Agents Suited for the Extraction of Biologically Active Vasopressin from Plasma].
    Date November 1980
    Journal Die Pharmazie
    Title Transmission of 14c-benzo(a)pyrene from Lactating Mice to Their Offspring.
    Date January 1977
    Journal Proceedings of the Western Pharmacology Society
    Title Introduction to the Theory of Elastic Neutron Scattering.
    Date November 1976
    Journal Brookhaven Symposia in Biology
    Title Polarization Dependence of Magnetic X-ray Scattering.
    Date
    Journal Physical Review. B, Condensed Matter
    Title Erratum: Polarization Dependence of Magnetic X-ray Scattering
    Date
    Journal Physical Review. B, Condensed Matter
    Title X-ray Resonance Exchange Scattering.
    Date
    Journal Physical Review Letters
    Title Joint Reconstruction of Image and Motion in Gated Positron Emission Tomography.
    Date
    Journal Ieee Transactions on Medical Imaging
    Excerpt

    We present a novel intrinsic method for joint reconstruction of both image and motion in positron emission tomography (PET). Intrinsic motion compensation methods exclusively work on the measured data, without any external motion measurements. Most of these methods separate image from motion estimation: They use deformable image registration/optical flow techniques in order to estimate the motion from individually reconstructed gates. Then, the image is estimated based on this motion information. With these methods, a main problem lies in the motion estimation step, which is based on the noisy gated frames. The more noise is present, the more inaccurate the image registration becomes. As we show both visually and quantitatively, joint reconstruction using a simple deformation field motion model can compete with state-of-the-art image registration methods which use robust multilevel B-spline motion models.

    Title A Constitutive Pan-hexose Permease for the Plasmodium Life Cycle and Transgenic Models for Screening of Antimalarial Sugar Analogs.
    Date
    Journal The Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology
    Excerpt

    Glucose is considered essential for erythrocytic stages of the malaria parasite, Plasmodium falciparum. Importance of sugar and its permease for hepatic and sexual stages of Plasmodium, however, remains elusive. Moreover, increasing global resistance to current antimalarials necessitates the search for novel drugs. Here, we reveal that hexose transporter 1 (HT1) of Plasmodium berghei can transport glucose (K(m)∼87 μ M), mannose (K(i)∼93 μ M), fructose (K(i)∼0.54 mM), and galactose (K(i)∼5 mM) in Leishmania mexicana mutant and Xenopus laevis; and, therefore, is functionally equivalent to HT1 of P. falciparum (Glc, K(m)∼175 μ M; Man, K(i)∼276 μ M; Fru, K(i)∼1.25 mM; Gal, K(i)∼5.86mM). Notably, a glucose analog, C3361, attenuated hepatic (IC(50)∼15 μ M) and ookinete development of P. berghei. The PbHT1 could be ablated during intraerythrocytic stages only by concurrent complementation with PbHT1-HA or PfHT1. Together; these results signify that PbHT1 and glucose are required for the entire life cycle of P. berghei. Accordingly, PbHT1 is expressed in the plasma membrane during all parasite stages. To permit a high-throughput screening of PfHT1 inhibitors and their subsequent in vivo assessment, we have generated Saccharomyces cerevisiae mutant expressing codon-optimized PfHT1, and a PfHT1-dependent Δpbht1 parasite strain. This work provides a platform to facilitate the development of drugs against malaria, and it suggests a disease-control aspect by reducing parasite transmission.-Blume, M., Hliscs, M., Rodriguez-Contreras, D., Sanchez, M., Landfear, S., Lucius, R., Matuschewski, K., Gupta, N. A constitutive pan-hexose permease for the Plasmodium life cycle and transgenic models for screening of antimalarial sugar analogs.


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