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Obstetrician & Gynecologist (OB/GYN)
18 years of experience
Video profile
Accepting new patients

Education ?

Medical School Score
Medical University of South Carolina (1992)
Obstetrics & Gynecology
  • Currently 2 of 4 apples
University of Texas Medical Branch (1996) *
* This information was reported to Vitals by the doctor or doctor's office.

Awards & Distinctions ?


Affiliations ?

Dr. Dent is affiliated with 1 hospitals.

Hospital Affilations



  • NCH Downtown Naples Hospital
    350 7th St N, Naples, FL 34102
    • Currently 4 of 4 crosses
    Top 25%
  • Publications & Research

    Dr. Dent has contributed to 2 publications.
    Title Neutrophil Aldose Reductase Activity As a Potential Marker for Neuropathy and Cataract in Diabetes.
    Date March 1992
    Journal Diabetic Medicine : a Journal of the British Diabetic Association

    Aldose reductase activity can be measured in the neutrophil and it has been proposed that this may be a marker for risk of complications in diabetes. We have studied aldose reductase activity in neutrophil, nerve, and lens in diabetic patients undergoing sural nerve biopsy or cataract extraction. A correlation was demonstrated between lens and neutrophil aldose reductase activity (r = 0.53, p = 0.01) but no correlations were demonstrated between nerve aldose reductase activities and nerve morphometry, nerve function or neutrophil aldose reductase activity. No significant difference was found between neutrophil aldose reductase activities in groups of patients with severe neuropathy, or cataract, or no complications (24 (interquartile range 16-32) vs 24 (16-40) vs 24 (16-40) nmol NADPH min-1 10(8)-cells-1). In a group of 56 Type 1 diabetic patients screened within 6 years of diagnosis, multiple regression analysis failed to show any relationship between neutrophil aldose reductase activity and abnormalities of neurophysiological function. These results suggest that neutrophil aldose reductase activity cannot be used as a marker for the development of cataract or neuropathy in diabetes.

    Title Neutrophil Aldose Reductase Activity and Its Association with Established Diabetic Microvascular Complications.
    Date September 1991
    Journal Diabetic Medicine : a Journal of the British Diabetic Association

    Direct investigation of the polyol pathway is rarely possible in studies of human diabetes. A spectrophotometric assay has been developed for the measurement of aldose reductase and sorbitol dehydrogenase activity in the neutrophil. Neutrophil aldose reductase activity was increased in patients with Type 1 diabetes with complications (median 40 (interquartile range 28-48) u, where 1 unit of enzyme activity = nmol NADPH min-1 10(8)-cells-1) compared with those without complications (20 (16-36) u, p less than 0.01) and normal control subjects (20 (8-36) u, p less than 0.01). In Type 2 diabetes, patients with complications also had higher aldose reductase activity (40 (28-52) u) than those without complications (24 (16-36) u, p less than 0.01). There were no differences between patients without complications and normal control subjects. Sorbitol dehydrogenase activity was decreased in diabetic patients (p less than 0.02) but not significantly different between diabetic patients with and without complications.

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