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Dr. Patrick Graupman, MD
Surgical Specialist, Neurological Surgeon
15 years of experience
Accepting new patients


Education ?

Medical School Score Rankings
University of Minnesota, Twin Cities (1997)
Top 25%

Awards & Distinctions ?

Uvm Burlington Vt
Assistant Professor
Congress of Neurological Surgeons
American Society of Pediatric Neurosurgeons
American Board of Neurological Surgery
American Association of Neurological Surgeons

Affiliations ?

Dr. Graupman is affiliated with 14 hospitals.

Hospital Affiliations



  • Healtheast St John's Hospital
    1575 Beam Ave, Saint Paul, MN 55109
    Top 25%
  • Healtheast Woodwinds Hospital
    1925 Woodwinds Dr, Saint Paul, MN 55125
    Top 25%
  • University of Minnesota Medical Center, Fairview
    2450 Riverside Ave, Minneapolis, MN 55454
    Top 25%
  • Healtheast St Joseph's Hospital
    69 Exchange St W, Saint Paul, MN 55102
    Top 50%
  • Regions Hospital
    640 Jackson St, Saint Paul, MN 55101
    Top 50%
  • HealthEast St. John`s
  • United Hospital
  • Childrens Hospitals and Clinics
  • Childrens St. Paul
    345 Smith Ave N, Saint Paul, MN 55102
  • St. Joseph's Hospital
    45 10th St E, Saint Paul, MN 55101
  • Gillette Children's Specialty Healthcare
    200 University Ave E, Saint Paul, MN 55101
  • Bethesda Rehabilitation Hospital
    559 Capitol Blvd, Saint Paul, MN 55103
  • Gillette Childrens Hospital
  • HealthEast St. Joseph`s
  • Publications & Research

    Dr. Graupman has contributed to 4 publications.
    Title Basicranial Diplomyelia: an Extension of the Split Cord Malformation Theory. Case Report.
    Date August 2006
    Journal Journal of Neurosurgery

    Basicranial diastematomyelia is an extremely rare congenital disorder. A review of the literature indicates only one reported case of basicranial diastematomyelia in which an osseous peg divided the brainstem in two. The authors present the first reported case of basicranial diplomyelia split by a fibrous band and correlate its pathogenesis with that of split cord malformation (SCM). The patient described in the present report had a fibrous stalk dividing the brainstem, and therefore the condition was categorized as a diplomyelia, or SCM Type II. Because the occipital dermatomes behave similarly to the spinal dermatomes early in development, they may be subject to the same embryonic error that results in SCM. The authors propose that the mechanism leading to SCM is the same as that found in basicranial split malformations and that the theory explaining it be modified to include the posterior fossa.

    Title Pediatric Intracranial Complications of Central Venous Catheter Placement.
    Date May 2004
    Journal Pediatric Neurosurgery

    Central venous catheters are essential in the medical management of critically ill pediatric patients. Medical practitioners should be aware of the potential for misplacement of these devices as such complications may result in serious injury and possible death. Catheter malpositioning is not limited to any particular site and may have far-reaching consequences that affect a single or multiple organ systems. We present two cases where central venous catheter positioning led to complications that resulted in intracranial pathology which was fatal in one case.

    Title Effects of Continuous Localized Infusion of Granulocyte-macrophage Colony-stimulating Factor and Inoculations of Irradiated Glioma Cells on Tumor Regression.
    Date June 1999
    Journal Journal of Neurosurgery

    OBJECT: Glioblastoma multiforme (GBM) is a malignant tumor of the central nervous system that directly suppresses immunological defenses in vitro and in vivo. The authors used the peripheral delivery of continuously infused granulocyte-macrophage colony-stimulating factor (GM-CSF) in the presence of irradiated tumor antigens as a tumor-specific stimulant to dendritic cells to initiate an immune response to GBM in rats. METHODS: The 9L gliosarcoma tumors were established in the flanks of syngeneic Fischer 344 rats. Osmotic minipumps implanted in the animals' contralateral flanks continuously delivered recombinant GM-CSF (0, 0.1, 1, or 10 ng/day) for 28 days. Irradiated gliosarcoma cells were intermittently injected at the site of the GM-CSF infusion. Animals in the saline control group (0 ng/day GM-CSF) died on Day 59 with average tumor volumes greater than 30,000 mm3. This control group was significantly different from the GM-CSF-treated animals, which all survived with average tumor volumes that peaked on Day 23 and later regressed completely. Tumor growth as well as peak tumor volumes (5833+/-2284 mm3, 3294+/-1632 mm3, and 1979+/-1142 mm3 for 0.1, 1, and 10 ng/day GM-CSF, respectively) in the different treatment groups reflected a significant dose-response relationship with the GM-CSF concentrations. All animals treated with GM-CSF and irradiated cells were resistant to additional challenges of peripheral and intracerebral gliosarcoma, even when they were inoculated 8 months after initial immunotherapy. The colocalization of GM-CSF and inactivated tumor antigens was required to stimulate immunoprotection. To test the efficacy of a peripherally administered immunological therapy on intracerebral brain tumors the authors transplanted 10(6) gliosarcoma cells into the striatum of treated and control animals. Subcutaneous pumps that released GM-CSF (10 ng/day) and irradiated gliosarcoma cells were placed in the treated animals. The control animals all died within 31 days after intracerebral tumor implantation. In contrast, 40% of the animals receiving GM-CSF-irradiated cell vaccinations survived beyond 300 days. These long-term survivors showed no evidence of gliosarcoma at the injection site on evaluation by magnetic resonance imaging. CONCLUSIONS: These results suggest that the continuous localized delivery of subcutaneous GM-CSF in conjunction with inactivated tumor antigens can initiate a systemic response that leads to the regression of distant peripheral and intracerebral tumors. The success of this treatment illustrates the feasibility of tumor-specific peripheral immunological stimulation after tumor resection to prevent the recurrence of malignant brain tumors.

    Title Thoracoscopic Sympathectomy for Palmar Hyperhidrosis. A Case Report.
    Date June 1997
    Journal Minnesota Medicine

    Palmar hyperhidrosis is a disabling condition that manifests itself as excessive sweating of the hands. Although the exact cause is unknown, several medical and surgical therapies are available to treat it. Recent developments in surgical technique have made the less invasive thoracoscopic sympathectomy a viable alternative to the open sympathectomy for medically refractory cases. We believe that thoracoscopic sympathectomy is a safe and effective treatment for palmar hyperhidrosis.

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