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Education ?

Medical School Score Rankings
University of Arizona (2005)
Top 50%

Awards & Distinctions ?

American Board of Family Medicine

Affiliations ?

Dr. Church is affiliated with 4 hospitals.

Hospital Affiliations



  • Providence Alaska Medical Center
    PO Box 196604, Anchorage, AK 99519
  • Alaska Regional Hospital
    2801 Debarr Rd, Anchorage, AK 99508
  • Providence Extended Care Center
    4900 Eagle St, Anchorage, AK 99503
  • Alaska Hospitalist Group, LLC
  • Publications & Research

    Dr. Church has contributed to 5 publications.
    Title A Mouse Model for Developing Treatment for Secondary Liver Tumors.
    Date September 2005
    Journal International Journal of Oncology

    Metastatic colorectal cancer is the second most common cause of cancer mortality. The liver is a common site of metastasis and only a minority of patients with liver metastases are candidates for potentially curative surgical resection. The treatment of patients with unresectable liver tumors is a major clinical problem and survival remains low. Many animal models of hepatic metastasis do not result in disease which resembles the advanced cancer setting. The purpose of this study was to establish a murine model for use in the evaluation of therapy for secondary liver cancer. Human colon cancer cells were injected directly into the portal vein of nude mice. Magnetic resonance imaging (MRI), performed weekly, was used to follow the time-course and characteristics of tumor growth. As expected, tumor size increased proportionately with time, following inoculation, and the MRI images correlated well with gross pathology findings at necropsy with respect to both tumor size and location. The tumors retained important morphology and biological characteristics of human colon cancer. Mice bearing liver metastasis were treated with irinotecan or drug vehicle. MRI evaluation pre/post-therapy gave an objective measure of therapeutic response. Irinotecan therapy was able to double the survival (median 76-93 days) compared to vehicle alone (median 43-46 days). This murine model is reproducible, rapid, inexpensive and has an excellent success rate for the development of liver metastasis (100%). When used in conjunction with small animal MRI, this model allows the efficient evaluation of the therapeutics of liver metastasis without the use of repeated laparotomy or splenectomy and without requiring large numbers of animals undergoing terminal experiments.

    Title Rna Profiling of Cyclooxygenases 1 and 2 in Colorectal Cancer.
    Date November 2004
    Journal British Journal of Cancer

    Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

    Title Molecular Predictors of Prognosis and Response to Therapy in Colorectal Cancer.
    Date September 2004
    Journal Cancer Chemotherapy and Biological Response Modifiers
    Title Cyclo-oxygenase 2 Inhibition in Colorectal Cancer Therapy.
    Date October 2003
    Journal The British Journal of Surgery

    BACKGROUND: Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the introduction of specific Cox-2 inhibitors. These drugs have implications for both the prevention of colorectal carcinoma and the potential treatment of the disease. METHODS AND RESULTS: A Medline database search was performed for articles using the keywords "colonic, colon or rectal and neoplasia or cancer" and "cyclo-oxygenase or Cox-2." Cross-references of relevant historical papers were also included. There is substantial evidence that Cox-2 plays a role in the development and progression of colorectal cancer. The specific inhibition of this enzyme has been shown to inhibit cancer growth in in vitro and in vivo models. The mechanisms of action for these effects are poorly understood and potential clinical applications at present remain under investigation. CONCLUSION: Cox-2 inhibitors have great promise as useful additions to current cancer treatments. There is a need for randomized clinical trials to define a role for these drugs in chemoprevention, recurrence prophylaxis, and adjuvant therapy for colorectal and other solid tumours.

    Title Using the Internet for Postgraduate Medical Education.
    Date July 1999
    Journal Hospital Medicine (london, England : 1998)

    Obtaining information from the Internet can be fun. As the Internet is unregulated, the quality of this information can vary enormously and time can be wasted searching poor quality websites. Despite this, use of the Internet for postgraduate medical education is increasing.

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