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Education ?

Medical School Score
University of South Dakota

Affiliations ?

Dr. Chelmo is affiliated with 1 hospitals.

Hospital Affiliations

  • Providence Kodiak Island Medical Center
    1915 E Rezanof Dr, Kodiak, AK 99615
  • Publications & Research

    Dr. Chelmo has contributed to 1 publication.
    Title Probing Structural Differences in Prion Protein Isoforms by Tyrosine Nitration.
    Date June 2007
    Journal Biochemistry

    Two conformational isomers of recombinant hamster prion protein (residues 90-232) have been probed by reaction with two tyrosine nitration reagents, peroxynitrite and tetranitromethane. Two conserved tyrosine residues (tyrosines 149 and 150) are not labeled by either reagent in the normal cellular form of the prion protein. These residues become reactive after the protein has been converted to the beta-oligomeric isoform, which is used as a model of the fibrillar form that causes disease. After conversion, a decrease in reactivity is noted for two other conserved residues, tyrosine 225 and tyrosine 226, whereas little to no effect was observed for other tyrosines. Thus, tyrosine nitration has identified two specific regions of the normal prion protein isoform that undergo a change in chemical environment upon conversion to a structure that is enriched in beta-sheet.

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