Browse Health
Internist, Cardiologist (heart)
23 years of experience
Video profile
Accepting new patients

Education ?

Medical School
St. George's University (1987)

Awards & Distinctions ?

American Board of Internal Medicine

Affiliations ?

Dr. Gopalan is affiliated with 4 hospitals.

Hospital Affilations



  • Bryn Mawr Rehabilitation Hospital
    414 Paoli Pike, Malvern, PA 19355
    • Currently 4 of 4 crosses
    Top 25%
  • Mayo Clinic Hospital
    5777 E Mayo Blvd, Phoenix, AZ 85054
    • Currently 3 of 4 crosses
    Top 50%
  • Main Line Hospital Paoli
    255 W Lancaster Ave, Paoli, PA 19301
    • Currently 3 of 4 crosses
    Top 50%
  • Main Line Hospital Lankenau
    100 E Lancaster Ave, Wynnewood, PA 19096
    • Currently 2 of 4 crosses
  • Publications & Research

    Dr. Gopalan has contributed to 5 publications.
    Title Unusual Case of Nonbacterial Thrombotic Endocarditis Attributable to Primary Antiphospholipid Syndrome.
    Date October 2010
    Journal Circulation
    Title Simultaneous Heart and Kidney Transplantation After Bridging with the Cardiowest Total Artificial Heart.
    Date October 2009
    Journal The Annals of Thoracic Surgery

    End-stage renal failure is often considered a relative contraindication for total artificial heart implantation due to the increased risk of mortality after transplantation. We report the successful treatment of a patient having heart and renal failure with the CardioWest (SynCardia Inc, Tucson, AZ) total artificial heart for bridge-to-cardiac transplantation of a heart and kidney.

    Title Hydrogen Bonding Patterns in the Cocrystals of 5-nitrouracil with Several Donor and Acceptor Molecules.
    Date April 2006
    Journal Beilstein Journal of Organic Chemistry

    : Cocrystals of 5-nitrouracil with solvent molecules, dioxane, pyridine, DMSO, formamide and ethanol as well as with piperazine, N, N'-dimethylpiperazine, 3-aminopyridine and diazabicyclo [2.2.2]octane obtained by deliberate inclusion, have been examined by X-ray crystallography. The tape structure found in the parent centric form of nitrouracil is retained with some modifications in the cocrystals with dioxane, piperazine, diazabicyclo [2.2.2]octane, N,N'-dimethylpiperazine, pyridine and DMSO, with the guest molecules forming alternate tapes. In cocrystals involving formamide, ethanol and 3-aminopyridine, the molecular tapes exhibit mixed compositions. The observed bonding patterns have been classified into six schemes. Interestingly, quadruple type hydrogen bonding patterns are seen in cocrystals containing 3-aminopyridine or ethanol and water, while a network of acyclic tetrahedral pentamers of water is found in the cocrystal containing diazabicyclo [2.2.2]octane and water.

    Title Novel Iron(iii) Complexes of Tripodal and Linear Tetradentate Bis(phenolate) Ligands: Close Relevance to Intradiol-cleaving Catechol Dioxygenases.
    Date April 2004
    Journal Inorganic Chemistry

    Four new iron(III) complexes of the bis(phenolate) ligands N,N-dimethyl-N',N'-bis(2-hydroxy-3,5-dimethylbenzyl)ethylenediamine [H2(L1)], N,N-dimethyl-N',N'-bis(2-hydroxy-4-nitrobenzyl)ethylenediamine [H2(L2)], N,N'-dimethyl-N,N'-bis(2-hydroxy-3,5-dimethylbenzyl)ethylenediamine [H2(L3)], and N,N'-dimethyl-N,N'-bis(2-hydroxy-4-nitrobenzyl)ethylenediamine [H2(L4)] have been isolated and studied as structural and functional models for the intradiol-cleaving catechol 1,2-dioxygenases (CTD). The complexes [Fe(L1)Cl] (1), [Fe(L2)(H2O)Cl] (2), [Fe(L3)Cl] (3), and [Fe(L4)(H2O)Cl] (4) have been characterized using absorption spectral and electrochemical techniques. The single-crystal X-ray structures of the ligand H2(L1) and the complexes 1 and 2 have been successfully determined. The tripodal ligand H2(L1) containing a N2O2 donor set represents the metal-binding region of the iron proteins. Complex 1 contains an FeN2O2Cl chromophore with a novel trigonal bipyramidal coordination geometry. While two phenolate oxygens and an amine nitrogen constitute the trigonal plane, the other amine nitrogen and chloride ion are located in the axial positions. In contrast, 2 exhibits a rhombically distorted octahedral coordination geometry for the FeN2O3Cl chromophore. Two phenolate oxygen atoms, an amine nitrogen atom, and a water molecule are located on the corners of a square plane with the axial positions being occupied by the other nitrogen atom and chloride ion. The interaction of the complexes with a few monodentate bases and phenolates and differently substituted catechols have been investigated using absorption spectral and electrochemical methods. The effect of substituents on the phenolate rings on the electronic spectral features and FeIII/FeII redox potentials of the complexes are discussed. The interaction of the complexes with catecholate anions reveals changes in the phenolate to iron(III) charge-transfer band and also the appearance of a low-energy catecholate to iron(III) charge-transfer band similar to catechol dioxygenase-substrate complexes. The redox behavior of the 1:1 adducts of the complexes with 3,5-di-tert-butylcatechol (H2DBC) has been also studied. The reactivities of the present complexes with H2DBC have been studied and illustrated. Interestingly, only 2 and 4 catalyze the intradiol-cleavage of H2DBC, the rate of oxygenation being much faster for 4. Also 2, but not 4, yields an extradiol cleavage product. The reactivity of the complexes could be illustrated not on the basis of the Lewis acidity of the complexes alone but by assuming that the product release is the rate-determining phase of the catalytic reaction.

    Title Trigonal Planar Copper(i) Complex: Synthesis, Structure, and Spectra of a Redox Pair of Novel Copper(ii/i) Complexes of Tridentate Bis(benzimidazol-2'-yl) Ligand Framework As Models for Electron-transfer Copper Proteins.
    Date July 2001
    Journal Inorganic Chemistry

    The copper(II) and copper(I) complexes of the chelating ligands 2,6-bis(benzimidazol-2'-ylthiomethyl)pyridine (bbtmp) and N,N-bis(benzimidazol-2'-ylthioethyl)methylamine (bbtma) have been isolated and characterized by electronic and EPR spectra. The molecular structures of a redox pair of Cu(II/I) complexes, viz., [Cu(bbtmp)(NO(3))]NO(3), 1, and [Cu(bbtmp)]NO(3), 2, and of [Cu(bbtmp)Cl], 3, have been determined by single-crystal X-ray crystallography. The cation of the green complex [Cu(bbtmp)(NO(3))]NO(3) possesses an almost perfectly square planar coordination geometry in which the corners are occupied by the pyridine and two benzimidazole nitrogen atoms of the bbtmp ligand and an oxygen atom of the nitrate ion. The light-yellow complex [Cu(bbtmp)]NO(3) contains copper(I) with trigonal planar coordination geometry constituted by the pyridine and two benzimidazole nitrogen atoms of the bbtmp ligand. In the yellow chloride complex [Cu(bbtmp)Cl] the asymmetric unit consists of two complex molecules that are crystallographically independent. The coordination geometry of copper(I) in these molecules, in contrast to the nitrate, is tetrahedral, with pyridine and two benzimidazole nitrogen atoms of bbtmp ligand and the chloride ion occupying the apexes. The above coordination structures are unusual in that the thioether sulfurs are not engaged in coordination and the presence of two seven-membered chelate rings facilitates strong coordination of the benzimidazole nitrogens and discourage any distortion in Cu(II) coordination geometry. The solid-state coordination geometries are retained even in solution, as revealed by electronic, EPR, and (1)H NMR spectra. The electrochemical behavior of the present and other similar CuN(3) complexes has been examined, and the thermodynamic aspects of the electrode process are correlated to the stereochemical reorganizations accompanying the redox changes. The influence of coordinated pyridine and amine nitrogen atoms on the spectral and electrochemical properties has been discussed.

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