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Obstetrician & Gynecologist (OB/GYN)
9 years of experience
Accepting new patients

Education ?

Medical School
Royal College Of Surgeons In Ireland (2001)
Foreign school

Awards & Distinctions ?

Associations
American Board of Obstetrics and Gynecology

Affiliations ?

Dr. Balgobin is affiliated with 4 hospitals.

Hospital Affilations

Score

Rankings

  • Parkland Health & Hospital System
    5201 Harry Hines Blvd, Dallas, TX 75235
    • Currently 1 of 4 crosses
  • UT Southwestern Zale Lipshy Hospital
  • UT Southwestern St Paul Hospital
  • St. Paul Hospital
  • Publications & Research

    Dr. Balgobin has contributed to 5 publications.
    Title Htid-1 Defines a Novel Regulator of C-met Receptor Signaling in Renal Cell Carcinomas.
    Date July 2011
    Journal Oncogene
    Excerpt

    The c-Met receptor tyrosine kinase (MetR) is frequently overexpressed and constitutively phosphorylated in a number of human malignancies. Activation of the receptor by its ligand, hepatocyte growth factor (HGF), leads to increased cell proliferation, motility, survival and disruption of adherens junctions. In this study, we show that hTid-1, a DNAJ/Hsp40 chaperone, represents a novel modulator of the MetR signaling pathway. hTid-1 is a co-chaperone of the Hsp70 family of proteins, and has been shown to regulate a number of cellular signaling proteins including several involved in tumorigenic and apoptotic pathways. In this study we demonstrate that hTid-1 binds to unphosphorylated MetR and becomes dissociated from the receptor upon HGF stimulation. Overexpression of the short form of hTid-1 (hTid-1(S)) in 786-0 renal clear cell carcinomas (RCCs) enhances MetR kinase activity leading to an increase in HGF-mediated cell migration with no discernible effect on cell proliferation. By contrast, knockdown of hTid-1 markedly impairs both the onset and amplitude of MetR phosphorylation in response to HGF without altering receptor protein levels. hTid-1-depleted cells display defective migratory properties, coincident with inhibition of ERK/MAP kinase and STAT3 pathways. Taken together, our findings denote hTid-1(S) as an essential regulatory component of MetR signaling. We propose that the binding of hTid-1(S) to MetR may stabilize the receptor in a ligand-competent state and this stabilizing function may influence conformational changes that take place during the catalytic cycle that promote kinase activation. Given the prevalence of HGF/MetR pathway activation in human cancers, targeted inhibition of hTid-1 may be a useful therapeutic in the management of MetR-dependent malignancies.

    Title Does Vaginal Size Impact Sexual Activity and Function?
    Date August 2010
    Journal International Urogynecology Journal and Pelvic Floor Dysfunction
    Excerpt

    This study seeks to determine if total vaginal length (TVL) or genital hiatus (GH) impact sexual activity and function.

    Title Effect of Anatomic Urethral Length on the Correlation Between the Q-tip Test and Descent at Point Aa of the Pop-q System.
    Date May 2008
    Journal International Urogynecology Journal and Pelvic Floor Dysfunction
    Excerpt

    The objective of this study is to evaluate the effect of anatomic urethral length on the relationship between descent at point Aa of the pelvic organ prolapse quantification (POP-Q) system and the Q-tip straining angle. The records of 323 patients who were evaluated for urinary incontinence were reviewed. Prolapse staging was performed using the POP-Q system. Urethrovesical junction hypermobility defined as a maximal straining angle > or =30 degrees was assessed with the Q-tip test. Urethral length was measured with a urethral profilometer. A substantial correlation was found between descent at point Aa and the straining Q-tip angle (r = 0.65, p < 0.0001). There was no correlation between the anatomic urethral length and straining Q-tip angle (r = -0.01, p = 0.8). Urethral length does not affect the straining Q-tip angle. Point Aa is a strong predictor of an abnormal straining Q-tip angle in women with stage I anterior vaginal wall prolapse or greater.

    Title Pyometra After Thermal Endometrial Ablation.
    Date September 2007
    Journal Obstetrics and Gynecology
    Excerpt

    BACKGROUND: Pyometra is a rare but serious complication after thermal endometrial ablation. CASE: A 48-year-old woman with type 2 diabetes and a prosthetic mitral valve underwent a thermal endometrial ablation for abnormal uterine bleeding. She subsequently developed pyometra that induced sepsis and cervical necrosis necessitating hysterectomy. CONCLUSION: The development of a pyometra after endometrial ablation is likely multifactorial.

    Title Nurse Educators Are Key to a Best Practices Implementation Program.
    Date August 2004
    Journal Geriatric Nursing (new York, N.y.)
    Excerpt

    In a statewide Best Practices Project, the involvement of nurse educators in the implementation process improved the overall success of participating long-term care facilities in improving the quality of resident care. Two nurse educators provided consultation and training to nursing facility staff on three best practice protocols: prevention of decline in the activities of daily living of eating and dressing, pain, and depression. Facility staff were given protocols to follow, together with documentation forms to assist in determining resident appropriateness for participation in the assigned best practice, assessing resident involvement in the protocol over time, and tracking staff progress with the implementation. The success of the 2-year first phase of the project in significantly improving measurable resident quality of care in best practice protocol areas has resulted in a second phase involving additional facilities and protocols.

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