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Allergy & Immunology Specialist, Pediatrician
40 years of experience

Education ?

Medical School Score Rankings
New York University (1970)
  • Currently 4 of 4 apples
Top 25%

Awards & Distinctions ?

Associations
American Board of Allergy and Immunology
American Board of Pediatrics

Publications & Research

Dr. Metcalf has contributed to 3 publications.
Title A Weight of Evidence Approach for Selecting Exposure Biomarkers for Biomonitoring.
Date July 2011
Journal Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Excerpt

It is known that there are usually several biomarkers and/or medium combinations that can be applied to answer a specific exposure question. To help determine an appropriate combination for the specific question, we have developed a weight-of-evidence Framework that provides a relative appropriateness score for competing combinations.

Title Biomarkers of Exposure in Community Settings.
Date June 2004
Journal Journal of Toxicology and Environmental Health. Part A
Excerpt

Biomonitoring is a valuable tool for assessing human exposures to chemical contaminants in the environment. Biomonitoring tests can be divided into biomarkers of exposure, effect, and susceptibility. In studies of community exposure to an environmental contaminant, biomarkers of exposure are most often used. The ideal biomarker should be sensitive, specific, biologically relevant, practical, inexpensive, and available. Seldom does a biomarker meet all of these criteria--most biomarkers represent a compromise of these criteria. In designing a community exposure study, consideration should also be given to the selection of the test population, the practicality of collecting biological samples, temporal or seasonal variations in exposure, the availability of background comparison ranges, and interpretation of the test results. Biomonitoring tests provide unequivocal evidence of exposure, but they do not typically identify the source of exposure. Furthermore, rarely do the test results predict a health outcome. For many chemicals, testing must be conducted soon after exposure has occurred. In spite of these limitations, the use of biomonitoring is finding wider application in many scientific disciplines. Recent advances in analytical techniques are expanding the utility of biomarker testing in public health investigations.

Title Astdr and the Trinity Industry Case Study. Agency for Toxic Substances and Disease Registry.
Date February 2002
Journal Aihaj : a Journal for the Science of Occupational and Environmental Health and Safety

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