advertisement
Browse Health

Credentials

Education ?

Medical School
American University Of Beirut (2001)
Foreign school

Awards & Distinctions ?

Associations
American Board of Pediatrics

Affiliations ?

Dr. Nasr is affiliated with 2 hospitals.

Hospital Affiliations

Score

Rankings

  • Banner Good Samaritan Regional Medical Center
    1111 E McDowell Rd, Phoenix, AZ 85006
    •  
    Top 25%
  • Phoenix Children's Hospital
    1919 E Thomas Rd, Phoenix, AZ 85016
    •  
    Top 50%
  • Publications & Research

    Dr. Nasr has contributed to 2 publications.
    Title The Probiotic Lactobacillus Gg May Augment Intestinal Host Defense by Regulating Apoptosis and Promoting Cytoprotective Responses in the Developing Murine Gut.
    Date December 2008
    Journal Pediatric Research
    Excerpt

    Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in preterm infants. Although its pathogenesis is poorly understood, inappropriate apoptosis of the mucosal epithelia has been implicated. Recent clinical trials have shown that probiotics may reduce the incidence of NEC, and probiotics have been shown to suppress intestinal epithelial apoptosis in cultured cells. However, little is known about their mechanism of action in the developing intestine in vivo. Here, we confirm that the probiotic Lactobacillus rhamnosus GG (LGG) reduces chemically induced intestinal epithelial apoptosis in vitro. Furthermore, we report for the first time that LGG administered orally to live animals can reduce chemically induced epithelial apoptosis ex vivo, as measured by staining for active caspase 3 and terminal deoxynucleotidyltransferase. Using cDNA microarray analysis from the intestine of live, orally inoculated mice, we show that LGG up-regulates a battery of genes with known and likely cytoprotective effects. These studies indicate that probiotics such as LGG may augment intestinal host defenses in the developing intestine by stimulating antiapoptotic and cytoprotective responses. Because apoptosis may be a precursor to NEC, understanding the mechanism behind probiotic modulation of apoptotic pathways may allow for development of more specifically targeted therapies or preventive strategies in the future.

    Title Necrotizing Enterocolitis: Recent Scientific Advances in Pathophysiology and Prevention.
    Date June 2008
    Journal Seminars in Perinatology
    Excerpt

    Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality among infants in the neonatal intensive care unit. Here we review the epidemiology and pathophysiology of NEC, with an emphasis on the latest research findings and potential areas for future research. NEC continues to be one of the most devastating and unpredictable diseases affecting premature infants. Despite decades of research, the pathogenesis of this disease remains unclear, and prevention and treatment strategies are limited. Hopefully, future studies aimed at understanding premature intestinal defenses, commensal or probiotic bacterial influences, and possible genetic predisposition will lead to the improvement of prevention and treatment strategies.

    Similar doctors nearby

    Dr. Michael Lang

    Pediatrics
    30 years experience
    Phoenix, AZ

    Dr. Pranav Patel

    Pediatrics
    15 years experience
    Phoenix, AZ

    Dr. Barbara Ianni

    Neonatal-Perinatal Medicine
    26 years experience
    Phoenix, AZ

    Dr. Amardeep Ahluwalia

    Pediatrics
    12 years experience
    Phoenix, AZ

    Dr. Matthew Abrams

    Pediatrics
    15 years experience
    Phoenix, AZ

    Dr. Katherine Weiss

    Pediatrics
    6 years experience
    Phoenix, AZ
    Search All Similar Doctors