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Neurologist (brain, nervous system)
35 years of experience
Video profile
Accepting new patients

Education ?

Medical School Score
Rosalind Franklin University (1975)
  • Currently 2 of 4 apples

Awards & Distinctions ?

Castle Connolly's Top Doctors™ (2012 - 2013)
On-Time Doctor Award (2014)
American Board of Psychiatry and Neurology
Consortium of Multiple Sclerosis Centers

Affiliations ?

Dr. Hornstein is affiliated with 9 hospitals.

Hospital Affilations



  • Orange Coast Memorial Medical Center
    9920 Talbert Ave, Fountain Valley, CA 92708
    • Currently 4 of 4 crosses
    Top 25%
  • St. Mary Medical Center *
    1050 Linden Ave, Long Beach, CA 90813
    • Currently 4 of 4 crosses
    Top 25%
  • Anaheim Memorial Medical Center
    1111 W La Palma Ave, Anaheim, CA 92801
    • Currently 4 of 4 crosses
    Top 25%
  • Long Beach Memorial Medical Center
    2801 Atlantic Ave, Long Beach, CA 90806
    • Currently 4 of 4 crosses
    Top 25%
  • Fountain Valley Regional Hospital & Medical Center
    17100 Euclid St, Fountain Valley, CA 92708
    • Currently 4 of 4 crosses
    Top 25%
  • Los Alamitos Medical Center
    3751 Katella Ave, Los Alamitos, CA 90720
    • Currently 4 of 4 crosses
    Top 25%
  • Downey Regional Medical Center
    11500 Brookshire Ave, Downey, CA 90241
    • Currently 4 of 4 crosses
    Top 25%
  • Lakewood Regional Medical Center
    3700 South St, Lakewood, CA 90712
    • Currently 3 of 4 crosses
    Top 50%
  • John Muir Medical Center-Concord Campus
  • * This information was reported to Vitals by the doctor or doctor's office.

    Publications & Research

    Dr. Hornstein has contributed to 1 publication.
    Title Alleviating Flu-like Symptoms with Dose Titration and Analgesics in Ms Patients on Intramuscular Interferon Beta-1a Therapy: a Pilot Study.
    Date September 2007
    Journal Current Medical Research and Opinion

    OBJECTIVE: To determine the effectiveness of dose titration and choice of analgesic in reducing flu-like side effects of intramuscular interferon beta-1a (i.m. IFNbeta-1a). METHODS: Patients were randomly assigned to receive weekly i.m. IFNbeta-1a, with or without dose titration, plus acetaminophen or ibuprofen. After 27 patients had been randomized, the original formulation of i.m. IFNbeta-1a became unavailable and the remaining patients used a pre-packaged liquid formulation, necessitating a change in protocol from initially quarter-dose to half-dose titration. Patients scored presence and intensity of muscle aches, chills, and weakness, and measured body temperature; information was recorded in diaries. RESULTS: Forty-seven patients were enrolled; 36 completed the study. Fifteen patients received full-dose therapy plus acetaminophen, eight patients received quarter-dose titration and acetaminophen, 10 patients received quarter-dose titration and ibuprofen, eight patients received half-dose titration and acetaminophen, and six patients received half-dose titration and ibuprofen. The mean number of acetaminophen doses taken was not statistically different from the mean number of ibuprofen doses taken per patient per week in any dose-titration group over measured time intervals (p > 0.05). Symptom scores from acetaminophen and ibuprofen dose-titration groups were combined and compared with the no-titration group. The proportion of patients with a mean increase of > or = 2 from baseline in flu-like symptom score trended lower in the titrated group compared with the no-titration group at 4 hours and 12-15 hours post-injection; these differences reached statistical significance only during the first 2 weeks of treatment (p = 0.015, quarter-dose vs. no titration). CONCLUSION: This study supports the findings of previous studies demonstrating no difference in the effectiveness of acetaminophen and ibuprofen in controlling flu-like symptoms associated with IFNbeta treatment in patients with relapsing-remitting MS. Trends in this small pilot study suggest that the combination of initial dose titration and analgesic administration is useful for the reduction of flu-like symptoms with IFNbeta-1a therapy.

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