The diagnosis of Tourette syndrome is one of exclusion, based on the history provided by the patient and the patient’s family.
The Diagnostic and Statistical Manual of Mental Disorders published by the American Psychiatric Association gives diagnostic criteria:
While there is no blood, laboratory or imaging medical tests that confirm the TS, it is imperative to perform tests to rule out other conditions that are linked with tics, especially if they are atypical or occur in adulthood.
| Test | Why Test? | What Happens? | What is Measured? |
|---|---|---|---|
|
Allergy Testing |
Exposure to allergen may cause sniffing, blinking or tic-like behavior |
A pad containing the allergen solution is taped to the skin for 24-72 hours. A raised area of skin with redness and itch denotes an allergic reaction. The test may be done by having a drop of solution with the allergen placed on the skin with scratches or needle pricks. If a raised, red and itchy area of the skin develops (wheal), an allergy is diagnosed to that allergen. (Positive reaction) |
No reaction to allergens detected |
|
MRI (Magnetic resonance imaging) |
Looking for brain injury, structural abnormality or infection within the brain |
You are asked to lie on your back on a table with head, torso and arms strapped down to prevent movement. The table then slides into the tunnel-like space that contains a magnet. You may hear banging or tapping noises from the magnet movement but are often offered piped in music to soothe you and mask the noise. Images are taken in body cross sections. The test usually takes 30-60 minutes and is painless |
No unusual break in brain integrity or cerebral vessels |
|
Blood Tests |
To rule out Wilson’s Disease |
After a tourniquet is applied to the upper arm, the puncture site of skin is swabbed with alcohol pads and a needle punctures the skin. Blood is then drawn into a syringe for analysis. The needle is removed and a pressure bandage is applied to the puncture site. |
Ceruloplasmin Comprehensive Metabolic Panel: Alkaline phosphatase SGPT=0-40 Bilirubin Calcium Carbon dioxide Chloride Male=.75-1.2 Female=.65-1.0 mg/dL Glucose Potassium Protein,total Sodium=137-147 mmol/L Urea Nitrogen (BUN) |
|
Strep Culture Blood Test for Streptococcus |
Rule out PANDAS disorder (Pediatric Acute-Onset Neuropsychiatric Syndrome) Blood test (twice with an interval) is done to look for anti-streptococcal antibody titers |
Swab is taken on the mouth and throat and placed on laboratory petri dish for analysis After a tourniquet is applied to the upper arm, the puncture site of skin is swabbed with alcohol pads and a needle punctures the skin. Blood is then drawn into a syringe for analysis. The needle is removed and a pressure bandage is applied to the puncture site. |
Culture is negative for Strep. Titers are negative for anti-streptococcal antibodies |
|
PET Scan (Positron Emission Tomography) |
Measures the activity of a mass, lump or node Used for staging of disease or response to treatment Distinguishes between lumps and scar tissue |
You will lie on an examination table and an IV may be inserted into a vein in your arm or hand. A radiotracer may be introduced into your body through the IV or you may be asked to swallow or inhale the substance. After one hour, you may drink a liquid containing contrast material. A CT scan will be performed followed by going into a PET scanner where imaging is performed. The test will take 30 minutes to 3 hours depending on the extent of tissue or organs to be evaluated. While the technician checks the images, you must remain on the table because additional images may need to be taken. Once satisfactory, the IV is removed and you may rise from the examining table. |
No tumors, masses or enlarged lymph nodes. No increased activity in organs, vessels and lymph nodes |
|
CT Scan (Computed tomography) |
Used to detect enlargement or abnormalities of organs, blood vessels, lymph nodes and soft tissue of the body |
You will be asked to lie on a narrow examination table. An intravenous needle and line may be inserted. You may be asked to swallow contrast material, which may be slightly unpleasant Restraints may or may not be used to maintain a still position. The table then slides into the center of a “tunnel-like” machine. The X-ray tube rotates around you and you may hear banging as imaging takes place. A speaker and microphone may be fixed into the chamber allowing you to talk and hear the technician as well as hearing piped in music. When satisfactory images are obtained, the table will slide out of the chamber and you may arise from the table. |
Normal sized organs, blood vessels and lymph nodes with no enlargements, distortions or abnormal shapes or narrowing. |
Written by Barbara Hales, M.D.
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